Search results
- 1.0585334 - FGÚ 2025 RIV GB eng J - Journal Article
Honzejková, K. - Košek, Dalibor - Obšilová, Veronika - Obšil, Tomáš
The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1.
eLife. Roč. 13, Mar 27 (2024), č. článku RP95199. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB III - 90242
Institutional support: RVO:67985823
Keywords : MAP3K * ASK1 kinase * Thioredoxin * cryo-EM
OECD category: Biochemistry and molecular biology
Impact factor: 7.7, year: 2022
Method of publishing: Open access
https://doi.org/10.7554/eLife.95199.2
Permanent Link: https://hdl.handle.net/11104/0353047 - 2.0576929 - FGÚ 2024 RIV US eng J - Journal Article
Petrvalská, Olivia - Honzejková, K. - Koupilová, N. - Herman, P. - Obšilová, Veronika - Obšil, Tomáš
14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices.
Protein Science. Roč. 32, č. 11 (2023), č. článku e4805. ISSN 0961-8368. E-ISSN 1469-896X
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823
Keywords : 14-3-3 proteins * calcium/calmodulin-dependent protein kinase * CaMKK * fluorescence spectroscopy * hydrogen/deuterium exchange coupled to MS * protein–protein interaction * SAXS
OECD category: Biochemistry and molecular biology
Impact factor: 8, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/pro.4805
Permanent Link: https://hdl.handle.net/11104/0346310 - 3.0562268 - FGÚ 2023 RIV US eng J - Journal Article
Kohoutová, Klára - Dočekal, V. - Ausserlechner, M. J. - Kaiser, N. - Tekel, A. - Mandal, R. - Horváth, M. - Obšilová, Veronika - Veselý, J. - Hagenbuchner, J. - Obšil, Tomáš
Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription.
ACS Omega. Roč. 7, č. 38 (2022), s. 34632-34646. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA ČR(CZ) GA21-02080S
Institutional support: RVO:67985823
Keywords : DNA binding * forkhead box O 3 * nuclear magnetic resonance * neuroblastoma * chemoresistance * senescence
OECD category: Biochemistry and molecular biology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsomega.2c04613
Permanent Link: https://hdl.handle.net/11104/0334626 - 4.0556577 - FGÚ 2023 RIV US eng J - Journal Article
Joshi, Rohit - Pohl, Pavel - Strachotová, D. - Herman, P. - Obšil, Tomáš - Obšilová, Veronika
Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains.
Biophysical Journal. Roč. 121, č. 7 (2022), s. 1299-1311. ISSN 0006-3495. E-ISSN 1542-0086
R&D Projects: GA ČR(CZ) GA20-00058S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823
Keywords : Nedd4-2 ubiquitin ligase * 14-3-3 protein * fluorescence spectroscopy * protein structure and function
OECD category: Biochemistry and molecular biology
Impact factor: 3.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bpj.2022.02.025
Permanent Link: http://hdl.handle.net/11104/0330738 - 5.0556576 - FGÚ 2023 RIV US eng J - Journal Article
Mandal, R. - Kohoutová, Klára - Petrvalská, Olivia - Horváth, M. - Srb, Pavel - Veverka, Václav - Obšilová, Veronika - Obšil, Tomáš
FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA.
Protein Science. Roč. 31, č. 5 (2022), č. článku e4287. ISSN 0961-8368. E-ISSN 1469-896X
R&D Projects: GA ČR(CZ) GA21-02080S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : DNA binding * forkhead box O 4 * nuclear magnetic resonance * protein-protein interaction * senescence * transcription factor p53
OECD category: Biochemistry and molecular biology
Impact factor: 8, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/pro.4287
Permanent Link: http://hdl.handle.net/11104/0330737 - 6.0551597 - FGÚ 2022 RIV CH eng J - Journal Article
Obšilová, Veronika - Honzejková, K. - Obšil, Tomáš
Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions.
International Journal of Molecular Sciences. Roč. 22, č. 24 (2021), č. článku 13395. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-00121S; GA ČR(CZ) GA20-00058S
Institutional support: RVO:67985823
Keywords : ASK1 * phosphorylation * MAP kinase * 14-3-3 * kinase * protein–protein interaction
OECD category: Biochemistry and molecular biology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/24/13395
Permanent Link: http://hdl.handle.net/11104/0326849 - 7.0545402 - FGÚ 2022 RIV GB eng J - Journal Article
Horváth, Matej - Petrvalská, Olivia - Herman, P. - Obšilová, Veronika - Obšil, Tomáš
14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.
Communications Biology. Roč. 4, č. 1 (2021), č. článku 986. E-ISSN 2399-3642
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823
Keywords : protein structure and function * protein kinase * DAPK * 14-3-3 protein * apoptosis * phosphorylation
OECD category: Biochemistry and molecular biology
Impact factor: 6.548, year: 2021
Method of publishing: Open access
https://doi.org/10.1038/s42003-021-02518-y
Permanent Link: http://hdl.handle.net/11104/0322100 - 8.0544647 - FGÚ 2022 RIV GB eng J - Journal Article
Pohl, Pavel - Joshi, Rohit - Petrvalská, Olivia - Obšil, Tomáš - Obšilová, Veronika
14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains.
Communications Biology. Roč. 4, č. 1 (2021), č. článku 899. E-ISSN 2399-3642
R&D Projects: GA ČR(CZ) GA20-00058S
Research Infrastructure: CIISB - 90043
Institutional support: RVO:67985823
Keywords : protein structure and function * ubiquitination * 14-3-3 protein * Nedd4-2 ubiquitin ligase * phosphorylation
OECD category: Biochemistry and molecular biology
Impact factor: 6.548, year: 2021
Method of publishing: Open access
https://doi.org/10.1038/s42003-021-02419-0
Permanent Link: http://hdl.handle.net/11104/0321481 - 9.0541623 - FGÚ 2022 RIV GB eng J - Journal Article
Neves, J. F. - Petrvalská, Olivia - Bosica, F. - Cantrelle, F. X. - Merzougui, H. - O'Mahony, G. - Hanoulle, X. - Obšil, Tomáš - Landrieu, I.
Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer.
FEBS Journal. Roč. 288, č. 6 (2021), s. 1918-1934. ISSN 1742-464X. E-ISSN 1742-4658
Institutional support: RVO:67985823
Keywords : 14‐3‐3 proteins * Alzheimer’s disease * analytical ultracentrifugation * NMR spectroscopy * protein–protein interactions * Tau protein
OECD category: Biochemistry and molecular biology
Impact factor: 5.622, year: 2021
Method of publishing: Open access
https://doi.org/10.1111/febs.15574
Permanent Link: http://hdl.handle.net/11104/0319156 - 10.0535685 - FGÚ 2021 RIV US eng J - Journal Article
Santo Lentini, D. - Petrvalská, Olivia - Obšilová, Veronika - Ottmann, Ch. - Obšil, Tomáš
Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins.
ACS Chemical Biology. Roč. 15, č. 11 (2020), s. 3060-3071. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823
Keywords : CaMKK2 * 14-3-3 * protein-protein interaction * fusicoccin * structure stabilization
OECD category: Biochemistry and molecular biology
Impact factor: 5.100, year: 2020
Method of publishing: Limited access
https://doi.org/10.1021/acschembio.0c00821
Permanent Link: http://hdl.handle.net/11104/0314528