Search results
- 1.0558978 - FGÚ 2023 RIV GB eng J - Journal Article
Kysilov, Bohdan - Hrčka Krausová, Barbora - Vyklický, Vojtěch - Smejkalová, Tereza - Kořínek, Miloslav - Horák, Martin - Chodounská, Hana - Kudová, Eva - Černý, Jiří - Vyklický ml., Ladislav
Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations.
British Journal of Pharmacology. Roč. 179, č. 15 (2022), s. 3970-3990. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA20-17945S; GA MZd(CZ) EF16_025/0007444; GA TA ČR(CZ) TN01000013
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : GRIN channelopathy * NMDA receptor * positive allosteric modulator * steroids * transmembrane domain
OECD category: Neurosciences (including psychophysiology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1111/bph.15841
Permanent Link: https://hdl.handle.net/11104/0332640 - 2.0543350 - FGÚ 2022 RIV US eng J - Journal Article
Kaniaková, Martina - Korábečný, J. - Holubová, Kristína - Kletečková, Lenka - Chvojková, Markéta - Hakenová, K. - Prchal, L. - Novák, M. - Doležal, R. - Hepnarová, V. - Svobodová, B. - Kučera, T. - Lichnerová, Katarina - Krausová, B. - Horák, Martin - Valeš, Karel - Soukup, O.
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo.
Biochemical Pharmacology. Roč. 186, Apr (2021), č. článku 114460. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:67985823
Keywords : behavioral experiment * electrophysiology * glutamate receptor * mutation * ion channel * acetylcholinesterase
OECD category: Pharmacology and pharmacy
Impact factor: 6.100, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.bcp.2021.114460
Permanent Link: http://hdl.handle.net/11104/0320571 - 3.0542659 - FGÚ 2022 RIV FR eng J - Journal Article
Gorecki, L. - Misiachna, Anna - Damborský, J. - Doležal, R. - Korábečný, J. - Čejková, L. - Hakenová, K. - Chvojková, M. - Zdarová Karasová, J. - Prchal, L. - Novák, M. - Kolcheva, Marharyta - Kortus, Štěpán - Valeš, K. - Horák, Martin - Soukup, O.
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.
European Journal of Medicinal Chemistry. Roč. 219, 5 July (2021), č. článku 113434. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:67985823
Keywords : QSAR * acetylcholinesterase * electrophysiology * glutamate receptor * ion channel * pharmacology * in vivo * tacrine
OECD category: Pharmacology and pharmacy
Impact factor: 7.088, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2021.113434
Permanent Link: http://hdl.handle.net/11104/0320032 - 4.0541685 - FGÚ 2022 RIV CH eng J - Journal Article
Konečný, J. - Misiachna, Anna - Hrabinová, M. - Pulkrábková, L. - Benková, M. - Prchal, L. - Kučera, T. - Kobrlová, T. - Finger, V. - Kolcheva, Marharyta - Kortus, Štěpán - Jun, D. - Valko, M. - Horák, Martin - Soukup, O. - Korábečný, J.
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.
Biomolecules. Roč. 11, č. 1 (2021), č. článku 3. E-ISSN 2218-273X
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:67985823
Keywords : acetylcholinesterase * Alzheimer´s disease * butyrylcholinesterase * fluorene * in vitro * in silico * multi-target directed ligands * N-methyl-d-aspartate receptor
OECD category: Pharmacology and pharmacy
Impact factor: 6.064, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2218-273X/11/1/3
Permanent Link: http://hdl.handle.net/11104/0319216 - 5.0535045 - FGÚ 2021 RIV US eng J - Journal Article
Park, DH. - Park, S. - Song, JM. - Kang, M. - Lee, S. - Horák, Martin - Suh, Y. H.
N-linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1.
FASEB Journal. Roč. 34, č. 11 (2020), s. 14977-14996. ISSN 0892-6638. E-ISSN 1530-6860
R&D Projects: GA ČR(CZ) GA18-04329S
Institutional support: RVO:67985823
Keywords : degradation * extracellular domain * trafficking * transsynaptic adhesion
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.192, year: 2020
Method of publishing: Limited access
https://doi.org/10.1096/fj.202001544R
Permanent Link: http://hdl.handle.net/11104/0313150 - 6.0531929 - FGÚ 2021 RIV GB eng J - Journal Article
Kořínek, Miloslav - González-González, I. M. - Smejkalová, Tereza - Hajduković, Dragana - Skřenková, Kristýna - Krůšek, Jan - Horák, Martin - Vyklický ml., Ladislav
Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission.
Scientific Reports. Roč. 10, č. 1 (2020), č. článku 12651. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA17-02300S; GA ČR(CZ) GJ16-03913Y; GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) LQ1604
Institutional support: RVO:67985823
Keywords : synaptic transmission * cholesterol * NMDA receptor * NMDA receptor * neuroprotection * synapse * membrane
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.380, year: 2020
Method of publishing: Open access
https://www.nature.com/articles/s41598-020-69454-5
Permanent Link: http://hdl.handle.net/11104/0310562 - 7.0511902 - FGÚ 2020 RIV NL eng J - Journal Article
Kaniaková, Martina - Nepovímová, E. - Kletečková, L. - Skřenková, K. - Holubová, K. - Chrienová, Z. - Hepnarová, V. - Kučera, T. - Kobrlová, T. - Valeš, K. - Korábečný, J. - Soukup, O. - Horák, Martin
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.
Current Alzheimer Research. Roč. 16, č. 9 (2019), s. 821-833. ISSN 1567-2050. E-ISSN 1875-5828
R&D Projects: GA ČR(CZ) GA16-08554S
Institutional support: RVO:67985823
Keywords : 6-Chlorotacrine * Alzheimer´s disease * NMDA receptor * acetylcholinesterase * ion channel * memantine * patch-clamp technique
OECD category: Neurosciences (including psychophysiology
Impact factor: 3.047, year: 2019
Method of publishing: Limited access
http://www.eurekaselect.com/170309/article
Permanent Link: http://hdl.handle.net/11104/0302140 - 8.0508566 - FGÚ 2020 RIV NL eng J - Journal Article
Hemelíková, Katarína - Kolcheva, Marharyta - Skřenková, Kristýna - Kaniaková, Martina - Horák, Martin
Lectins modulate the functional properties of GluN1/GluN3-containing NMDA receptors.
Neuropharmacology. Roč. 157, Oct (2019), č. článku UNSP 107671. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA18-04329S
Institutional support: RVO:67985823
Keywords : glycosylation * glutamate receptor * ion channel * patch-clamp technique * desensitization * posttranslational modification
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.431, year: 2019
Method of publishing: Limited access
https://doi.org/10.1016/j.neuropharm.2019.107671
Permanent Link: http://hdl.handle.net/11104/0299434 - 9.0508561 - FGÚ 2020 RIV GB eng J - Journal Article
Skřenková, Kristýna - Hemelíková, Katarína - Kolcheva, Marharyta - Kortus, S. - Kaniaková, Martina - Krausová, Barbora - Horák, Martin
Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors.
Scientific Reports. Roč. 9, Aug 23 (2019), č. článku 12303. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA18-04329S; GA MŠMT(CZ) LM2015062
Institutional support: RVO:67985823
Keywords : desensitisation * glutamate receptor * mammalian neuron * ion channel * intracellular trafficking * pathogenic mutation
OECD category: Neurosciences (including psychophysiology
Impact factor: 3.998, year: 2019
Method of publishing: Open access
https://doi.org/10.1038/s41598-019-48845-3
Permanent Link: http://hdl.handle.net/11104/0299431 - 10.0495300 - FGÚ 2019 RIV NL eng J - Journal Article
Kaniaková, Martina - Kletečková, Lenka - Lichnerová, Katarina - Holubová, Kristína - Skřenková, K. - Kořínek, Miloslav - Krůšek, Jan - Smejkalová, Tereza - Korábečný, J. - Valeš, Karel - Soukup, O. - Horák, Martin
7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo.
Neuropharmacology. Roč. 140, Sep 15 (2018), s. 217-232. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA16-08554S
Institutional support: RVO:67985823
Keywords : behavioural experiment * electrophysiology * glutamate receptor * human pathogenic mutation * ion channel * pharmacology
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.367, year: 2018
Permanent Link: http://hdl.handle.net/11104/0288296