Search results
- 1.0572565 - ÚOCHB 2024 RIV US eng J - Journal Article
Skácel, Jan - Djukic, Stefan - Baszczyňski, Ondřej - Kalčic, Filip - Bílek, Tadeáš - Chalupský, Karel - Kozák, Jaroslav - Dvořáková, Alexandra - Tloušťová, Eva - Kráľová, Zuzana - Šmídková, Markéta - Voldřich, Jan - Rumlová, M. - Pachl, Petr - Brynda, Jiří - Vučková, Tereza - Fábry, Milan - Snášel, Jan - Pichová, Iva - Řezáčová, Pavlína - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
Journal of Medicinal Chemistry. Roč. 66, č. 10 (2023), s. 6652-6681. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : multisubstrate analog inhibitors * transition-state analog * human erythrocytes
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c02097
Permanent Link: https://hdl.handle.net/11104/0343213File Download Size Commentary Version Access 10.1021acs.jmedchem.2c02097.pdf 1 5.7 MB Publisher’s postprint open-access - 2.0552686 - ÚOCHB 2023 RIV GB eng J - Journal Article
Lášek, Tomáš - Petrová, Magdalena - Markusová Kóšiová, Ivana - Šimák, Ondřej - Buděšínský, Miloš - Kozák, Jaroslav - Snášel, Jan - Vavřina, Zdeněk - Birkuš, Gabriel - Rosenberg, Ivan - Páv, Ondřej
5′-Phosphonate modified oligoadenylates as potent activators of human RNase L.
Bioorganic & Medicinal Chemistry. Roč. 56, Feb 15 (2022), č. článku 116632. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : RNase L * Oligoadenylate * Phosphonate oligonucleotide * OAS-RNase L pathway * 2-5A
OECD category: Biochemistry and molecular biology
Impact factor: 3.5, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bmc.2022.116632
Permanent Link: http://hdl.handle.net/11104/0327809 - 3.0539494 - ÚOCHB 2022 RIV CH eng J - Journal Article
Snášel, Jan - Machová, Iva - Šolínová, Veronika - Kašička, Václav - Krečmerová, Marcela - Pichová, Iva
Phosphofructokinases a and b from mycobacterium tuberculosis display different catalytic properties and allosteric regulation.
International Journal of Molecular Sciences. Roč. 22, č. 3 (2021), č. článku 1483. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : Mycobacterium tuberculosis * glycolysis * phosphofructokinase A and B * allosteric regulation * enzyme kinetics
OECD category: Biochemistry and molecular biology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/ijms22031483
Permanent Link: http://hdl.handle.net/11104/0317591 - 4.0501819 - ÚOCHB 2020 RIV NL eng J - Journal Article
Snášel, Jan - Pichová, Iva
Allosteric regulation of pyruvate kinase from Mycobacterium tuberculosis by metabolites.
Biochimica Et Biophysica Acta-Proteins and Proteomics. Roč. 1867, č. 2 (2019), s. 125-139. ISSN 1570-9639. E-ISSN 1878-1454
R&D Projects: GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : pyruvate kinase * Mycobacterium tuberculosis * allosteric regulation * metabolites * ions * metabolism
OECD category: Biochemistry and molecular biology
Impact factor: 2.371, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S1570963918302000?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0296398 - 5.0474974 - ÚOCHB 2018 RIV US eng J - Journal Article
Machová, Iva - Hubálek, Martin - Lepšík, Martin - Bednárová, Lucie - Pazderková, Markéta - Kopecký, V. Jr. - Snášel, Jan - Dostál, Jiří - Pichová, Iva
The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis.
PLoS ONE. Roč. 12, č. 1 (2017), č. článku e0170373. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA MŠMT LO1302; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963
Keywords : structural insights * metabolism * parameters
OECD category: Biochemistry and molecular biology
Impact factor: 2.766, year: 2017
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170373
Permanent Link: http://hdl.handle.net/11104/0271862File Download Size Commentary Version Access 0474974.pdf 4 1.7 MB Publisher’s postprint open-access - 6.0445290 - ÚOCHB 2016 RIV DE eng J - Journal Article
Malnuit, Vincent - Poštová Slavětínská, Lenka - Nauš, Petr - Džubák, P. - Hajdúch, M. - Stolaříková, J. - Snášel, Jan - Pichová, Iva - Hocek, Michal
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.
ChemMedChem. Roč. 10, č. 6 (2015), s. 1079-1093. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA ČR GAP207/11/0344; GA MŠMT(CZ) LO1304; GA MŠMT LO1302; GA TA ČR(CZ) TE01020028
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Institutional support: RVO:61388963
Keywords : antimycobacterial agents * cytostatics * nucleosides * purines * pyrrolopyrimidines
Subject RIV: CC - Organic Chemistry
Impact factor: 2.980, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247636 - 7.0444002 - ÚOCHB 2016 RIV US eng J - Journal Article
Machová, Iva - Snášel, Jan - Dostál, Jiří - Brynda, Jiří - Fanfrlík, Jindřich - Singh, M. - Tarábek, Ján - Vaněk, O. - Bednárová, Lucie - Pichová, Iva
Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis.
PLoS ONE. Roč. 10, č. 3 (2015), e0120682/1-e0120682/21. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA MŠMT LO1302
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Institutional support: RVO:61388963
Keywords : crystal structure * noncovalent complexes * Mycobacterium tuberculosis * mechanism
Subject RIV: CE - Biochemistry
Impact factor: 3.057, year: 2015
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120682
Permanent Link: http://hdl.handle.net/11104/0246696File Download Size Commentary Version Access 0444002.PDF 0 3.5 MB Publisher’s postprint open-access - 8.0436116 - ÚOCHB 2015 RIV US eng J - Journal Article
Snášel, Jan - Nauš, Petr - Dostál, Jiří - Hnízda, Aleš - Fanfrlík, Jindřich - Brynda, Jiří - Bourderioux, Aurelie - Dušek, Michal - Dvořáková, H. - Stolaříková, J. - Zábranská, Helena - Pohl, Radek - Konečný, P. - Džubák, P. - Votruba, Ivan - Hajdúch, M. - Řezáčová, Pavlína - Veverka, Václav - Hocek, Michal - Pichová, Iva
Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides.
Journal of Medicinal Chemistry. Roč. 57, č. 20 (2014), s. 8268-8279. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0344; GA MŠMT LO1302; GA MŠMT(CZ) LK11205
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Grant - others:GA MŠk(CZ) LM2011020
Institutional support: RVO:61388963 ; RVO:68378271
Keywords : 7-(het)aryl-7-deazaadenine ribonucleosides * enzyme inhibition * adenosine kinase * cytostatic activity
Subject RIV: CC - Organic Chemistry
Impact factor: 5.447, year: 2014
Permanent Link: http://hdl.handle.net/11104/0239959 - 9.0429470 - ÚOCHB 2015 RIV US eng J - Journal Article
Machová, Iva - Snášel, Jan - Zimmermann, M. - Laubitz, D. - Plocinski, P. - Oehlmann, W. - Singh, M. - Dostál, Jiří - Sauer, U. - Pichová, Iva
Mycobacterium tuberculosis Phosphoenolpyruvate Carboxykinase Is Regulated by Redox Mechanisms and Interaction with Thioredoxin.
Journal of Biological Chemistry. Roč. 289, č. 19 (2014), s. 13066-13078. ISSN 0021-9258. E-ISSN 1083-351X
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Grant - others:OPPK(CZ) CZ.2.16/3.1.00/24016
Institutional support: RVO:61388963
Keywords : enzyme kinetics * hypoxia * metabolism * Mycobacterium tuberculosis * oxidation-reduction * thioredoxin * Phosphoenolpyruvate carboxykinase
Subject RIV: CE - Biochemistry
Impact factor: 4.573, year: 2014
Permanent Link: http://hdl.handle.net/11104/0234607 - 10.0399777 - ÚOCHB 2014 RIV GB eng J - Journal Article
Perlíková, Pavla - Konečný, P. - Nauš, Petr - Snášel, Jan - Votruba, Ivan - Džubák, P. - Pichová, Iva - Hajdúch, M. - Hocek, Michal
6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents.
MedChemComm. Roč. 4, č. 11 (2013), s. 1497-1500. ISSN 2040-2503. E-ISSN 2040-2511
R&D Projects: GA ČR GAP207/11/0344
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Grant - others:Operational Programme Research and Development for Innovations(XE) CZ.1.05/2.1.00/01.0030
Institutional support: RVO:61388963
Keywords : mycobacterium-tuberculosis * enzyme-inhibition * 6-(het)aryl-7-deazapurine ribonucleosides
Subject RIV: CC - Organic Chemistry
Impact factor: 2.626, year: 2013
Permanent Link: http://hdl.handle.net/11104/0227143