Search results
- 1.0443227 - ÚOCHB 2016 RIV FR eng J - Journal Article
Vorlová, Barbora - Nachtigallová, Dana - Jirásková-Vaníčková, Jana - Ajani, Haresh - Jansa, Petr - Řezáč, Jan - Fanfrlík, Jindřich - Otyepka, M. - Hobza, Pavel - Konvalinka, Jan - Lepšík, Martin
Malonate-based inhibitors of mammalian serine racemase: Kinetic characterization and structure-based computational study.
European Journal of Medicinal Chemistry. Roč. 89, Jan 7 (2015), s. 189-197. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR GBP208/12/G016
Grant - others:GA MŠk(CZ) ED2.1.00/03.0058
Program: ED
Institutional support: RVO:61388963
Keywords : NMDA receptor * pyridoxal-5 '-phosphate-dependent enzyme * human/mouse serine racemase * malonate-based inhibitors * semiempirical quantum mechanical calculations
Subject RIV: CE - Biochemistry
Impact factor: 3.902, year: 2015
Permanent Link: http://hdl.handle.net/11104/0246045 - 2.0370154 - ÚOCHB 2012 RIV NL eng J - Journal Article
Jirásková-Vaníčková, Jana - Ettrich, Rüdiger - Vorlová, Barbora - Hoffman, Hillary Elizabeth - Lepšík, Martin - Jansa, Petr - Konvalinka, Jan
Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry.
Current Drug Targets. Roč. 12, č. 7 (2011), s. 1037-1055. ISSN 1389-4501. E-ISSN 1873-5592
R&D Projects: GA MŠMT 1M0508; GA ČR GA203/08/0114
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z60870520
Keywords : amino acid analogs * L-erythro-3-hydroxyaspartate (L-EHA) * D-serine * neurodegenerative diseases * NMDA receptors * pyridoxal-5´-phosphate (PLP)
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 3.553, year: 2011
Permanent Link: http://hdl.handle.net/11104/0204037 - 3.0343324 - ÚOCHB 2011 RIV CZ eng J - Journal Article
Hoffman, Hillary Elizabeth - Jirásková, Jana - Zvelebil, M. - Konvalinka, Jan
Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity.
Collection of Czechoslovak Chemical Communications. Roč. 75, č. 1 (2010), s. 59-79. ISSN 0010-0765
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : D-serine * serine racemase * random mutagenesis
Subject RIV: CE - Biochemistry
Impact factor: 0.853, year: 2010
Permanent Link: http://hdl.handle.net/11104/0185830 - 4.0335989 - ÚOCHB 2010 RIV US eng J - Journal Article
Hoffman, Hillary Elizabeth - Jirásková, Jana - Ingr, M. - Zvelebil, M. - Konvalinka, Jan
Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog.
Protein Expression and Purification. Roč. 63, č. 1 (2009), s. 62-67. ISSN 1046-5928. E-ISSN 1096-0279
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : D-serin * serin racemase * gene synthesis
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 1.563, year: 2009
Permanent Link: http://hdl.handle.net/11104/0180324 - 5.0330745 - ÚOCHB 2010 RIV US eng J - Journal Article
Hoffman, Hillary Elizabeth - Jirásková, Jana - Cígler, Petr - Šanda, Miloslav - Schraml, Jan - Konvalinka, Jan
Hydroxamic acids as a novel family of serine racemase inhibitors: Mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.
Journal of Medicinal Chemistry. Roč. 52, č. 19 (2009), s. 6032-6041. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT 1M0508; GA AV ČR IAA400720706
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z40720504
Keywords : hydroxamic acids * serine racemase * d-serine * pyridoxal-5'-phosphate
Subject RIV: CE - Biochemistry
Impact factor: 4.802, year: 2009
Permanent Link: http://hdl.handle.net/11104/0176459 - 6.0194764 - UOCHB-X 20030069 RIV NL eng J - Journal Article
Stříšovský, Kvido - Jirásková, Jana - Bařinka, Cyril - Majer, P. - Rojas, C. - Slusher, B. S. - Konvalinka, Jan
Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate.
FEBS Letters. Roč. 535, - (2003), s. 44-48. ISSN 0014-5793. E-ISSN 1873-3468
R&D Projects: GA AV ČR IAA5055108
Institutional research plan: CEZ:AV0Z4055905
Keywords : serine racemase * pyridoxal phosphate * glutamate receptor agonist
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.609, year: 2003
Permanent Link: http://hdl.handle.net/11104/0090435 - 7.0042878 - ÚOCHB 2007 RIV DE eng J - Journal Article
Koval, Dušan - Jirásková, Jana - Stříšovský, Kvido - Konvalinka, Jan - Kašička, Václav
Capillary electrophoresis method for the determination of D-serine and its application for monitoring of serine racemase activity.
[Kapilárně-elektroforetická metoda pro stanovení D-serinu a její využití pro sledování aktivity serin-racemasy.]
Electrophoresis. Roč. 27, č. 13 (2006), s. 2558-2566. ISSN 0173-0835. E-ISSN 1522-2683
R&D Projects: GA MŠMT(CZ) LC512; GA ČR(CZ) GA203/04/0098; GA ČR(CZ) GA203/05/2539
Institutional research plan: CEZ:AV0Z40550506
Keywords : capillary electrophoresis * D-serine * serine racemase
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 4.101, year: 2006
Permanent Link: http://hdl.handle.net/11104/0136013 - 8.0025452 - ÚOCHB 2006 RIV US eng J - Journal Article
Stříšovský, Kvido - Jirásková, Jana - Mikulová, Adriana - Rulíšek, Lubomír - Konvalinka, Jan
Dual substrate and reaction specificity in mouse serine racemase: Identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity.
[Dvojitá specifita serinové racemasy.]
Biochemistry. Roč. 44, č. 39 (2005), s. 13091-13100. ISSN 0006-2960
R&D Projects: GA MŠMT(CZ) LC512
Institutional research plan: CEZ:AV0Z40550506
Keywords : serine racemase * enzyme inhibition * molecular modelling
Subject RIV: CE - Biochemistry
Impact factor: 3.848, year: 2005
Permanent Link: http://hdl.handle.net/11104/0115838