Search results
- 1.0532046 - ÚOCHB 2021 RIV NL eng J - Journal Article
Konkoľová, Eva - Dejmek, Milan - Hřebabecký, Hubert - Šála, Michal - Böserle, Jiří - Nencka, Radim - Bouřa, Evžen
Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses.
Antiviral Research. Roč. 182, Oct (2020), č. článku 104899. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : remdesivir * inhibitor * flavivirus * RNA-dependent RNA polymerase
OECD category: Organic chemistry
Impact factor: 5.970, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.antiviral.2020.104899
Permanent Link: http://hdl.handle.net/11104/0310659 - 2.0525539 - ÚOCHB 2021 RIV US eng J - Journal Article
Šála, Michal - Hollinger, K. R. - Thomas, A. G. - Dash, R. P. - Tallon, C. - Veeravalli, V. - Lovell, L. - Kögler, Martin - Hřebabecký, Hubert - Procházková, Eliška - Nešuta, Ondřej - Donoghue, A. - Lam, J. - Rais, R. - Rojas, C. - Slusher, B. S. - Nencka, Radim
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
Journal of Medicinal Chemistry. Roč. 63, č. 11 (2020), s. 6028-6056. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : cognitive impairment * in vivo * metabolism
OECD category: Organic chemistry
Impact factor: 7.446, year: 2020
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00278
Permanent Link: http://hdl.handle.net/11104/0309645 - 3.0523373 - ÚOCHB 2021 RIV GB eng J - Journal Article
Köprülüoglu, Cemal - Dejmek, Milan - Šála, Michal - Ajani, Haresh - Hřebabecký, Hubert - Fanfrlík, Jindřich - Jorda, Radek - Dračínský, Martin - Procházková, Eliška - Šácha, Pavel - Kryštof, Vladimír - Hobza, Pavel - Lepšík, Martin - Nencka, Radim
Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors.
Journal of Molecular Recognition. Roč. 33, č. 8 (2020), č. článku e2842. ISSN 0952-3499. E-ISSN 1099-1352
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61389030
Keywords : ATP-competitive type I inhibitors * cyclin-dependent kinase 2 * protein-ligand binding * quantum mechanical scoring
OECD category: Physical chemistry
Impact factor: 2.137, year: 2020
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmr.2842
Permanent Link: http://hdl.handle.net/11104/0307732 - 4.0519335 - ÚOCHB 2021 RIV GB eng J - Journal Article
Procházková, Eliška - Hřebabecký, Hubert - Dejmek, Milan - Šála, Michal - Šmídková, Markéta - Tloušťová, Eva - Zborníková, Eva - Eyer, Luděk - Růžek, Daniel - Nencka, Radim
Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?
Bioorganic and Medicinal Chemistry Letters. Roč. 30, č. 4 (2020), č. článku 126897. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA MZd(CZ) NV16-34238A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : antiviral * nucleotide * prodrug * ProTide * HCV * 31P NMR spectroscopy
OECD category: Organic chemistry; Microbiology (BC-A)
Impact factor: 2.823, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0304523 - 5.0489990 - ÚOCHB 2019 RIV GB eng J - Journal Article
Iannazzo, L. - Fonvielle, M. - Braud, E. - Hřebabecký, Hubert - Procházková, Eliška - Nencka, Radim - Mathé, C. - Arthur, M. - Etheve-Quelquejeu, M.
Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes.
Organic & Biomolecular Chemistry. Roč. 16, č. 11 (2018), s. 1903-1911. ISSN 1477-0520. E-ISSN 1477-0539
Institutional support: RVO:61388963
Keywords : HIV-1 reverse transcriptase * aminoacyl transfer RNA * cell wall synthesis
OECD category: Organic chemistry
Impact factor: 3.490, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284283 - 6.0482595 - ÚOCHB 2018 RIV US eng J - Journal Article
Hřebabecký, Hubert - Dračínský, Martin - Procházková, Eliška - Šála, Michal - Mackman, R. - Nencka, Radim
Control of alpha/beta Anomer Formation by a 2',5' Bridge: Toward Nucleoside Derivatives Locked in the South Conformation.
Journal of Organic Chemistry. Roč. 82, č. 21 (2017), s. 11337-11347. ISSN 0022-3263. E-ISSN 1520-6904
R&D Projects: GA ČR(CZ) GA16-20054S
Institutional support: RVO:61388963
Keywords : borne encephalitis virus * ring closing metathesis * nucleotide analogs
OECD category: Organic chemistry
Impact factor: 4.805, year: 2017
Permanent Link: http://hdl.handle.net/11104/0278006 - 7.0474801 - ÚOCHB 2018 RIV NL eng J - Journal Article
Hercík, Kamil - Kozák, Jaroslav - Šála, Michal - Dejmek, Milan - Hřebabecký, Hubert - Zborníková, Eva - Smola, Miroslav - Růžek, Daniel - Nencka, Radim - Bouřa, Evžen
Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.
Antiviral Research. Roč. 137, Jan (2017), s. 131-133. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA ČR GA15-09310S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : hepatitis C virus * borne encephalitis virus * crystal structure
OECD category: Organic chemistry
Impact factor: 4.307, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271754 - 8.0474385 - ÚOCHB 2018 RIV US eng J - Journal Article
Mejdrová, Ivana - Chalupská, Dominika - Plačková, Pavla - Müller, C. - Šála, Michal - Klíma, Martin - Bäumlová, Adriana - Hřebabecký, Hubert - Procházková, Eliška - Dejmek, Milan - Strunin, Dmytro - Weber, Jan - Lee, G. - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Ziebuhr, J. - Birkuš, G. - Bouřa, Evžen - Nencka, Radim
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase III beta (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Journal of Medicinal Chemistry. Roč. 60, č. 1 (2017), s. 100-118. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA15-09310S
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : C virus replication * lipid kinase * crystal structure
OECD category: Organic chemistry
Impact factor: 6.253, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271447
Research data: CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank - 9.0463545 - ÚOCHB 2017 RIV US eng J - Journal Article
Plačková, Pavla - Šála, Michal - Šmídková, Markéta - Dejmek, Milan - Hřebabecký, Hubert - Nencka, Radim - Thibaut, H. J. - Neyts, J. - Mertlíková-Kaiserová, Helena
9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction.
Free Radical Biology and Medicine. Roč. 97, Aug (2016), s. 223-235. ISSN 0891-5849. E-ISSN 1873-4596
R&D Projects: GA MŠMT LO1302; GA ČR GAP303/11/1297
Institutional support: RVO:61388963
Keywords : glutathione-S-transferase * oxidative stress * leukemia
Subject RIV: CE - Biochemistry
Impact factor: 5.606, year: 2016
http://www.sciencedirect.com/science/article/pii/S0891584916302921
Permanent Link: http://hdl.handle.net/11104/0262713File Download Size Commentary Version Access 0463545.pdf 5 2 MB Publisher’s postprint open-access - 10.0460249 - ÚOCHB 2017 RIV GB eng J - Journal Article
Šála, Michal - Kögler, Martin - Plačková, Pavla - Mejdrová, Ivana - Hřebabecký, Hubert - Procházková, Eliška - Strunin, Dmytro - Lee, G. - Birkuš, G. - Weber, Jan - Mertlíková-Kaiserová, Helena - Nencka, Radim
Purine analogs as phosphatidylinositol 4-kinase III beta inhibitors.
Bioorganic and Medicinal Chemistry Letters. Roč. 26, č. 11 (2016), s. 2706-2712. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA ČR GA15-09310S; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : phosphatidylinositol 4-kinase * purine * PI4K III beta * antiviral agent * hepatitis C virus
Subject RIV: CC - Organic Chemistry
Impact factor: 2.454, year: 2016
Permanent Link: http://hdl.handle.net/11104/0260372