Search results
- 1.0577921 - ÚOCHB 2024 RIV GB eng J - Journal Article
Kraina, Pavel - Česnek, Michal - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Fulton, C. J. - Davidson, E. K. - Smith, B. P. - Watts, V. J. - Janeba, Zlatko
Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir.
Bioorganic & Medicinal Chemistry. Roč. 95, November (2023), č. článku 117508. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adefovir * 7-deazapurine * prodrugs * adenylate cyclase
OECD category: Organic chemistry
Impact factor: 3.5, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bmc.2023.117508
Permanent Link: https://hdl.handle.net/11104/0346999 - 2.0556761 - ÚOCHB 2023 RIV US eng J - Journal Article
Klejch, Tomáš - Keough, D. T. - King, G. - Doleželová, Eva - Česnek, Michal - Buděšínský, Miloš - Zíková, Alena - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
Journal of Medicinal Chemistry. Roč. 65, č. 5 (2022), s. 4030-4057. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA19-07707S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : hypoxanthine-guanine phosporibosyltransferase * Plasmodium falciparum * Helicobacter pylori
OECD category: Medicinal chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01881
Permanent Link: http://hdl.handle.net/11104/0330950 - 3.0551643 - ÚOCHB 2023 RIV DE eng J - Journal Article
Česnek, Michal - Šafránek, Michal - Dračínský, Martin - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Hayes, M. P. - Watts, V. J. - Janeba, Zlatko
Halogen-Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases.
ChemMedChem. Roč. 17, č. 1 (2022), č. článku e202100568. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adenylate cyclase * Bordetella pertussis * inhibitors * prodrugs
OECD category: Organic chemistry
Impact factor: 3.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/cmdc.202100568
Permanent Link: http://hdl.handle.net/11104/0326883 - 4.0543267 - ÚOCHB 2022 RIV FR eng J - Journal Article
Břehová, Petra - Chaloupecká, Ema - Česnek, Michal - Skácel, Jan - Dračínský, Martin - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Soto-Velasquez, M. P. - Watts, V. J. - Janeba, Zlatko
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
European Journal of Medicinal Chemistry. Roč. 222, Oct 15 (2021), č. článku 113581. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adefovir * adenylate cyclase * Bacillus anthracis * Bordetella pertussis * inhibitors * prodrugs
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113581
Permanent Link: http://hdl.handle.net/11104/0320504 - 5.0500199 - ÚOCHB 2019 RIV GB eng J - Journal Article
Baszczyňski, Ondřej - Kaiser, Martin Maxmilian - Česnek, Michal - Břehová, Petra - Jansa, Petr - Procházková, Eliška - Dračínský, Martin - Snoeck, R. - Andrei, G. - Janeba, Zlatko
Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus.
Antiviral Chemistry and Chemotherapy. Roč. 26, Nov 29 (2018), s. 1-13. ISSN 0956-3202
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * xanthine * PMEX * antiviral * HCMV * VZV
OECD category: Organic chemistry
https://journals.sagepub.com/doi/10.1177/2040206618813050
Permanent Link: http://hdl.handle.net/11104/0292843 - 6.0493604 - ÚOCHB 2019 RIV DE eng J - Journal Article
Česnek, Michal - Skácel, Jan - Jansa, Petr - Dračínský, Martin - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Soto-Velasquez, M. - Watts, V. J. - Janeba, Zlatko
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
ChemMedChem. Roč. 13, č. 17 (2018), s. 1779-1796. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MV VG20102015046; GA ČR(CZ) GBP208/12/G016; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : adefovir * adenylate cyclase * Bacillus anthracis * Bordetella pertussis * inhibitors
OECD category: Organic chemistry
Impact factor: 3.016, year: 2018
Permanent Link: http://hdl.handle.net/11104/0286939 - 7.0465607 - ÚOCHB 2017 RIV GB eng J - Journal Article
Terán, D. - Hocková, Dana - Česnek, Michal - Zíková, Alena - Naesens, L. - Keough, D. T. - Guddat, L. W.
Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.
Scientific Reports. Roč. 6, Oct 27 (2016), č. článku 35894. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : enzyme inhibitors * acyclic nucleoside phosphonates * HGPRT
Subject RIV: CC - Organic Chemistry; EE - Microbiology, Virology (BC-A)
Impact factor: 4.259, year: 2016
http://www.nature.com/articles/srep35894
Permanent Link: http://hdl.handle.net/11104/0264085 - 8.0446744 - ÚOCHB 2016 RIV DE eng J - Journal Article
Česnek, Michal - Jansa, Petr - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Dračínský, Martin - Brust, T. F. - Pávek, P. - Trejtnar, F. - Watts, V. J. - Janeba, Zlatko
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
ChemMedChem. Roč. 10, č. 8 (2015), s. 1351-1364. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : adenylate cyclase toxin * bisamidates * Bordetella pertussis * nucleosides * phosphonates
Subject RIV: CC - Organic Chemistry
Impact factor: 2.980, year: 2015
Permanent Link: http://hdl.handle.net/11104/0248752 - 9.0427655 - ÚOCHB 2015 RIV US eng J - Journal Article
Šmídková, Markéta - Dvořáková, Alexandra - Tloušťová, Eva - Česnek, Michal - Janeba, Zlatko - Mertlíková-Kaiserová, Helena
Amidate Prodrugs of 9-[2-(Phosphonomethoxy)Ethyl]Adenine as Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
Antimicrobial Agents and Chemotherapy. Roč. 58, č. 2 (2014), s. 664-671. ISSN 0066-4804. E-ISSN 1098-6596
R&D Projects: GA MV VG20102015046
Grant - others:OPPC(XE) CZ.2.16/3.1.00/24016
Institutional support: RVO:61388963
Keywords : Bordetella pertussis * adenylate cyclase toxin * ACT * inhibitors * PMEA * amidate prodrugs
Subject RIV: CC - Organic Chemistry
Impact factor: 4.476, year: 2014
Permanent Link: http://hdl.handle.net/11104/0233171 - 10.0397563 - ÚOCHB 2014 RIV IE eng J - Journal Article
Mandíková, J. - Volková, M. - Pávek, P. - Česnek, Michal - Janeba, Zlatko - Kubíček, V. - Trejtnar, F.
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.
Toxicology. Roč. 311, č. 3 (2013), s. 135-146. ISSN 0300-483X
Institutional support: RVO:61388963
Keywords : hOAT1 * hCNTs * MDR1 * BCRP * nephrotoxicity * transmembrane transport
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 3.745, year: 2013
Permanent Link: http://hdl.handle.net/11104/0225187