Search results
- 1.0518502 - ÚOCHB 2020 CZ eng A - Abstract
Hocková, Dana - Doleželová, Eva - Terán, D. - Špaček, Petr - Česnek, Michal - Gahura, Ondřej - Kotrbová, Zuzana - Keough, D. T. - Zíková, Alena - Guddat, L. W.
Acyclic nucleoside phosphonates as inhibitors of Trypanosoma brucei 6-oxopurine phosphoribosyltransferases.
Liblice 2019. 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2019. s. 89.
[Liblice 2019. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /54./. 06.11.2019-08.11.2019, Špindlerův Mlýn]
R&D Projects: GA ČR(CZ) GA16-06049S; GA MŠMT(CZ) LL1205
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : nucleotide analogues * enzyme inhibitors * HG(X)PRT
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0303896 - 2.0518498 - ÚOCHB 2020 TH eng A - Abstract
Česnek, Michal - Šafránek, Michal - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, W. J. - Janeba, Zlatko
Synthesis of 5-[2-(phosphonomethoxy)ethyl] (PME) derivatives of 4-substituted 2-aminothiazoles as potential inhibitors of bacterial and human adenylate cyclases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.005, „P1005“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institutional support: RVO:61388963
Keywords : adenylate cyclases * aminothiazoles
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0303886 - 3.0481195 - ÚOCHB 2018 CZ eng A - Abstract
Česnek, Michal - Dračínský, Martin - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, V. J. - Janeba, Zlatko
Synthesis and evaluation of novel acyclic nucleoside phosphonates with unnatural nucleobases as potent inhibitors of Bordetella pertussis adenylate cyclase toxin.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 128.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
R&D Projects: GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0276795 - 4.0468400 - ÚOCHB 2017 DK eng A - Abstract
Terán, D. - Hocková, Dana - Česnek, Michal - Keough, D. T. - Guddat, L. W.
Crystal structures of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Acta Crystallographica Section A. Oxford Blackwell. Roč. 72, Suppl. (2016), S207. ISSN 0108-7673. E-ISSN 2053-2733.
[European Crystallographic Meeting /30./. 28.08.2016-01.09.2016, Basel]
Institutional support: RVO:61388963
Keywords : 6-oxopurine phosphoribosyltransferase * enzyme inhibitors * acyclic nucleoside phosphonates
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0266258 - 5.0465086 - ÚOCHB 2017 AU eng A - Abstract
Terán, D. - Hocková, Dana - Česnek, Michal - Keough, D. T. - Guddat, L. W.
Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase.
International Congress for Tropical Medicine and Malaria 2016. Brisbane: Australian Society for Parasitology, 2016. s. 435.
[ICTMM 2016. International Congress for Tropical Medicine and Malaria /19./. 18.09.2016-22.09.2016, Brisbane]
Institutional support: RVO:61388963
Keywords : HGPRT * enzyme inhibitors * acyclic nucleoside phosphonates
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0263804 - 6.0464964 - ÚOCHB 2017 ES eng A - Abstract
Česnek, Michal - Šmídková, Markéta - Dračínský, Martin - Janeba, Zlatko
Novel acyclic nucleoside phosphonates containing unnatural nucleobases as potent inhibitors of Bordetella pertussis adenylyl cyclase toxin.
17th Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry. Sitges: Elsevier, 2016.
[Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry /17./. 28.06.2016-01.07.2016, Sitges]
R&D Projects: GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0263704 - 7.0442819 - ÚOCHB 2016 GB eng A - Abstract
Šmídková, Markéta - Dvořáková, Alexandra - Tloušťová, Eva - Česnek, Michal - Janeba, Zlatko - Mertlíková-Kaiserová, Helena
Amidate prodrugs of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as inhibitors of adenylate cyclase toxin from Bordetella pertussis.
FEBS Journal. Roč. 281, Suppl S1 (2014), s. 729. ISSN 1742-464X. E-ISSN 1742-4658.
[FEBS EMBO 2014 Conference. 30.08.2014-04.09.2014, Paris]
R&D Projects: GA MŠMT LO1302; GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : Bordetella pertussis * adenylyl cyclase toxin * inhibitors
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0245642 - 8.0422674 - ÚOCHB 2014 FR eng A - Abstract
Česnek, Michal - Jansa, Petr - Dračínský, Martin - Šmídková, Markéta - Dvořáková, Alexandra - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Synthesis and biological evaluation of 2-substituted 9-[2-(phosphonomethoxy)ethyl]adenine derivatives.
ESOC 2013. 18th European Symposium on Organic Chemistry. Marseille: -, 2013. s. 85-85.
[ESOC 2013. European Symposium on Organic Chemistry /18./. 07.07.2013-12.07.2013, Marseille]
R&D Projects: GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : PMEA * adenylyl cyclase toxin * phosphonate
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0228952 - 9.0399048 - ÚOCHB 2014 US eng A - Abstract
Mandíková, J. - Volková, M. - Pávek, P. - Česnek, Michal - Janeba, Zlatko - Trejtnar, F.
Interactions of acyclic nucleoside phosphonates with selected renal SLC and ABC transporters.
26th International Conference on Antiviral Research (ICAR). San Francisco: International Society for Antiviral Research (ISAR), 2013. s. 101-101.
[International Conference on Antiviral Research /26./. 11.05.2013-15.05.2013, San Francisco]
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * antiviral * organic anion transporters * nephrotoxicity
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0226443 - 10.0384671 - ÚOCHB 2013 ES eng A - Abstract
Česnek, Michal - Jansa, Petr - Holý, Antonín - Dračínský, Martin - Baszczyňski, Ondřej - Janeba, Zlatko
Efficient and ‘green’ microwave-assisted synthesis of haloalkylphosphonates via Michaelis-Arbuzov reaction.
Zing Conferences: Microwave and Flow Conference. Lanzarote: -, 2012. s. 50-50.
[Zing Conferences: Microwave and Flow Conference. 28.02.2012-02.03.2012, Lanzarote]
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : microwave-assisted * Michaelis Arbuzov * phosphonates
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0214240