Search results
- 1.0525539 - ÚOCHB 2021 RIV US eng J - Journal Article
Šála, Michal - Hollinger, K. R. - Thomas, A. G. - Dash, R. P. - Tallon, C. - Veeravalli, V. - Lovell, L. - Kögler, Martin - Hřebabecký, Hubert - Procházková, Eliška - Nešuta, Ondřej - Donoghue, A. - Lam, J. - Rais, R. - Rojas, C. - Slusher, B. S. - Nencka, Radim
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
Journal of Medicinal Chemistry. Roč. 63, č. 11 (2020), s. 6028-6056. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : cognitive impairment * in vivo * metabolism
OECD category: Organic chemistry
Impact factor: 7.446, year: 2020
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00278
Permanent Link: http://hdl.handle.net/11104/0309645 - 2.0510199 - ÚOCHB 2020 RIV GB eng J - Journal Article
Rojas, C. - Šála, Michal - Thomas, A. G. - Chaudhury, A. D. - Yoo, S.-W. - Li, Z. - Dash, R. P. - Rais, R. - Haughey, N. J. - Nencka, Radim - Slusher, B.
A novel and potent brain penetrant inhibitor of extracellular vesicle release.
British Journal of Pharmacology. Roč. 176, č. 19 (2019), s. 3857-3870. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : Alzheimer's disease pathology * gene expression * in vivo
OECD category: Pharmacology and pharmacy
Impact factor: 7.730, year: 2019
Method of publishing: Limited access
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14789
Permanent Link: http://hdl.handle.net/11104/0300723 - 3.0501815 - ÚOCHB 2020 RIV GB eng J - Journal Article
Zhu, X. - Nedelcovych, M. T. - Thomas, A. G. - Hasegawa, Y. - Moreno-Megui, A. - Coomer, W. - Vohra, V. - Saito, A. - Perez, G. - Wu, Y. - Alt, J. - Prchalová, E. - Tenora, Lukáš - Majer, Pavel - Rais, R. - Rojas, C. - Slusher, B. S. - Kamiya, A.
JHU-083 selectively blocks glutaminase activity in brain CD11b(+) cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Neuropsychopharmacology. Roč. 44, č. 4 (2019), s. 683-694. ISSN 0893-133X. E-ISSN 1740-634X
Institutional support: RVO:61388963
Keywords : treatment resistant depression * anxiety-like behavior * prefrontal cortex
OECD category: Neurosciences (including psychophysiology
Impact factor: 6.751, year: 2019
Method of publishing: Open access
https://www.nature.com/articles/s41386-018-0177-7
Permanent Link: http://hdl.handle.net/11104/0296395 - 4.0501629 - BTÚ 2019 RIV GB eng J - Journal Article
Bařinka, Cyril - Nováková, Zora - Hin, N. - Bím, Daniel - Ferraris, D. V. - Duvall, B. - Kabarriti, G. - Tsukamoto, R. - Buděšínský, Miloš - Motlová, Lucia - Rojas, C. - Slusher, B. S. - Rokob, T. A. - Rulíšek, Lubomír - Tsukamoto, T.
Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.
Bioorganic & Medicinal Chemistry. Roč. 27, č. 2 (2019), s. 255-264. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) LM2015043; GA MŠMT(CZ) EF16_013/0001776; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA17-24155S
Grant - others:Ga MŠk(CZ) LM2015070
Institutional support: RVO:86652036 ; RVO:61388963
Keywords : Glutamate carboxypeptidase II * Prostate-specific membrane antigen * Crystal structure
OECD category: Biochemistry and molecular biology; Physical chemistry (UOCHB-X)
Impact factor: 3.073, year: 2019
Permanent Link: http://hdl.handle.net/11104/0293626 - 5.0489560 - ÚOCHB 2019 RIV US eng J - Journal Article
Rojas, C. - Stathis, M. - Coughlin, J. M. - Pomper, M. - Slusher, Barbara S.
The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.
Journal of Neuroimmune Pharmacology. Roč. 13, č. 1 (2018), s. 1-5. ISSN 1557-1890. E-ISSN 1557-1904
Institutional support: RVO:61388963
Keywords : translocator protein 18KDa (TSPO) * allosteric modulation * residence time
OECD category: Organic chemistry
Impact factor: 3.870, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283957 - 6.0480357 - ÚOCHB 2018 RIV US eng J - Journal Article
Nedelcovych, M. - Dash, R. P. - Tenora, Lukáš - Zimmermann, S. C. - Gadiano, A. J. - Garrett, C. - Alt, J. - Hollinger, K. R. - Pommier, E. - Jančařík, Andrej - Rojas, C. - Thomas, A. G. - Wu, Y. - Wozniak, K. - Majer, Pavel - Slusher, B. S. - Rais, R.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its gamma-Substituted Ester Prodrugs.
Molecular Pharmaceutics. Roč. 14, č. 10 (2017), s. 3248-3257. ISSN 1543-8384. E-ISSN 1543-8392
Institutional support: RVO:61388963
Keywords : 2-PMPA * glutamate carboxypeptidase II * neurological disease * intranasal * pharmacokinetics * prodrugs
OECD category: Organic chemistry
Impact factor: 4.556, year: 2017
Permanent Link: http://hdl.handle.net/11104/0276143 - 7.0469171 - BTÚ 2017 RIV US eng J - Journal Article
Nováková, Zora - Wozniak, K. - Jančařík, Andrej - Rais, R. - Wu, Y. - Pavlíček, Jiří - Ferraris, D. - Havlínová, Barbora - Ptáček, Jakub - Vávra, Jan - Hin, N. - Rojas, C. - Majer, Pavel - Slusher, B. S. - Tsukamoto, T. - Bařinka, Cyril
Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity.
Journal of Medicinal Chemistry. Roč. 59, č. 10 (2016), s. 4539-4550. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR GAP301/12/1513
Institutional support: RVO:86652036 ; RVO:61388963
Keywords : LINKED ACIDIC DIPEPTIDASE * N-ACETYLASPARTYLGLUTAMATE NAAG * THIOL-BASED INHIBITORS
Subject RIV: FR - Pharmacology ; Medidal Chemistry; CC - Organic Chemistry (UOCHB-X)
Impact factor: 6.259, year: 2016
Permanent Link: http://hdl.handle.net/11104/0267014 - 8.0467212 - BTÚ 2017 RIV NL eng J - Journal Article
Conway, R. E. - Rojas, C. - Alt, J. - Nováková, Zora - Richardson, S. M. - Rodrick, T. C. - Fuentes, J. L. - Richardson, N. H. - Attalla, J. - Stewart, S. - Fahmy, B. - Bařinka, Cyril - Ghosh, M. - Shapiro, L. H. - Slusher, B. S.
Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide.
Angiogenesis. Roč. 19, č. 4 (2016), s. 487-500. ISSN 0969-6970. E-ISSN 1573-7209
R&D Projects: GA ČR GAP301/12/1513; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : TUMOR-ASSOCIATED NEOVASCULATURE * BASEMENT-MEMBRANE * DISTINCT ANTITUMOR PROPERTIES
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 5.253, year: 2016
Permanent Link: http://hdl.handle.net/11104/0265323 - 9.0464672 - ÚOCHB 2017 RIV US eng J - Journal Article
Rais, R. - Jančařík, Andrej - Tenora, Lukáš - Nedelcovych, M. - Alt, J. - Englert, J. - Rojas, C. - Le, A. - Elgogary, A. - Tan, J. - Monincová, Lenka - Pate, K. - Adams, R. - Ferraris, D. - Powell, J. - Majer, Pavel - Slusher, B. S.
Discovery of 6-Diazo-5-oxo-L-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.
Journal of Medicinal Chemistry. Roč. 59, č. 18 (2016), s. 8621-8633. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:61388963
Keywords : phase I * glutamine metabolism * adjuvant temozolomide
Subject RIV: CC - Organic Chemistry
Impact factor: 6.259, year: 2016
Permanent Link: http://hdl.handle.net/11104/0263477 - 10.0427622 - ÚOCHB 2015 RIV US eng J - Journal Article
Ferraris, D. V. - Majer, Pavel - Ni, C. - Slusher, C. E. - Rais, R. - Wu, Y. - Wozniak, K. M. - Alt, J. - Rojas, C. - Slusher, B. S. - Tsukamoto, T.
delta-Thiolactones as Prodrugs of Thiol-Based Glutamate Carboxypeptidase II (GCPII) Inhibitors.
Journal of Medicinal Chemistry. Roč. 57, č. 1 (2014), s. 243-247. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:61388963
Keywords : pharmacokinetics * discovery * disorders * diagnosis * pain
Subject RIV: CC - Organic Chemistry
Impact factor: 5.447, year: 2014
Permanent Link: http://hdl.handle.net/11104/0233159