Search results
- 1.0502470 - BFÚ 2019 RIV IE eng J - Journal Article
Strapáčová, S. - Brenerová, P. - Krčmář, P. - Andersson, P. - van Ede, K.I. - van Duursen, M. B. M. - van den Berg, M. - Vondráček, Jan - Machala, M.
Relative effective potencies of dioxin-like compounds in rodent and human lung cell models.
Toxicology. Roč. 404, JUL 1 2018 (2018), s. 33-41. ISSN 0300-483X
Institutional support: RVO:68081707
Keywords : aryl-hydrocarbon receptor * dose-response relationships * cyp1a2 enzyme-activity
OECD category: Pharmacology and pharmacy
Impact factor: 3.547, year: 2018
Permanent Link: http://hdl.handle.net/11104/0294403 - 2.0491108 - BFÚ 2019 RIV US eng J - Journal Article
Tylichová, Zuzana - Slavík, J. - Cigánek, M. - Ovesná, P. - Krčmář, P. - Straková, Nicol - Machala, M. - Kozubík, Alois - Hofmanová, Jiřina - Vondráček, Jan
Butyrate and docosahexaenoic acid interact in alterations of specific lipid classes in differentiating colon cancer cells.
Journal of Cellular Biochemistry. Roč. 119, č. 6 (2018), s. 4664-4679. ISSN 0730-2312. E-ISSN 1097-4644
R&D Projects: GA MZd(CZ) NV15-30585A; GA ČR GA13-09766S
Institutional support: RVO:68081707
Keywords : polyunsaturated fatty-acids * stearoyl-coa desaturase * gene-expression
OECD category: Biochemistry and molecular biology
Impact factor: 3.448, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285183 - 3.0366512 - BFÚ 2012 RIV IE eng J - Journal Article
Umannová, Lenka - Machala, M. - Topinka, Jan - Schmuczerová, Jana - Krčmář, P. - Neča, J. - Šujanová, Klára - Kozubík, Alois - Vondráček, Jan
Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.
Toxicology Letters. Roč. 206, č. 2 (2011), s. 121-129. ISSN 0378-4274. E-ISSN 1879-3169
R&D Projects: GA ČR(CZ) GAP503/11/1227
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : DNA adducts * proinflammatory cytokines * COX-2
Subject RIV: BO - Biophysics
Impact factor: 3.230, year: 2011
Permanent Link: http://hdl.handle.net/11104/0201482 - 4.0347299 - BFÚ 2011 RIV IE eng J - Journal Article
Hrubá, E. - Trilecová, L. - Marvanová, S. - Krčmář, P. - Vykopalová, L. - Milcová, Alena - Líbalová, Helena - Topinka, Jan - Staršíchová, Andrea - Souček, Karel - Vondráček, Jan - Machala, M.
Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells.
Toxicology Letters. Roč. 198, č. 3 (2010), s. 227-235. ISSN 0378-4274. E-ISSN 1879-3169
Grant - others:GA ČR(CZ) GA310/07/0961
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : prostate epithelial cells * DNA adducts * carcinogenesis
Subject RIV: BO - Biophysics
Impact factor: 3.581, year: 2010
Permanent Link: http://hdl.handle.net/11104/0188104 - 5.0334274 - BFÚ 2010 RIV GB eng J - Journal Article
Lincová, Eva - Hampl, Aleš - Pernicová, Zuzana - Staršíchová, Andrea - Krčmář, P. - Machala, M. - Kozubík, Alois - Souček, Karel
Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs.
[Mnohočetné poruchy v negativní regulaci signální dráhy PKB/Akt zcitlivují lidské nádorové buňky k antiproliferačním účinku nesteroidních antiflogistik.]
Biochemical Pharmacology. Roč. 78, č. 6 (2009), s. 561-572. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA204/07/0834; GA ČR(CZ) GA301/07/1557; GA AV ČR(CZ) 1QS500040507
Grant - others:GA ČR(CZ) GA310/07/0961
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : PKB/Akt signaling pathway * NSAIDs * prostate cancer
Subject RIV: BO - Biophysics
Impact factor: 4.254, year: 2009
Permanent Link: http://hdl.handle.net/11104/0179056 - 6.0327184 - BFÚ 2010 RIV NL eng J - Journal Article
Vondráček, Jan - Krčmář, P. - Procházková, Jiřina - Trilecová, L. - Gavelová, M. - Skálová, L. - Szotáková, B. - Bunček, M. - Radilová, H. - Kozubík, Alois - Machala, M.
The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells.
[Úloha Ah receptoru v regulaci enzymů podílejících se na metabolické aktivaci polycyklických aromatických uhlovodíků v modelu jaterních progenitorových buněk potkana.]
Chemico-Biological Interactions. Roč. 180, č. 2 (2009), s. 226-237. ISSN 0009-2797. E-ISSN 1872-7786
R&D Projects: GA ČR(CZ) GA524/06/0517
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : cytochromes P450 * PAHs * aldo-keto reductases
Subject RIV: BO - Biophysics
Impact factor: 2.457, year: 2009
Permanent Link: http://hdl.handle.net/11104/0174072 - 7.0327032 - BFÚ 2010 RIV NL eng J - Journal Article
Šimečková, P. - Vondráček, J. - Procházková, J. - Kozubík, Alois - Krčmář, P. - Machala, M.
2,2', 4,4',5,5'-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.
[2,2', 4,4',5,5'-Hexachlorobiphenyl (PCB 153) způsobuje degradaci proteinů tvořících adherentní spoje a inhibuje v jaterních epiteliálních buňkách transkripci kontrolovanou beta-kateninem.]
Toxicology. Roč. 260, 1-3 (2009), s. 104-111. ISSN 0300-483X
R&D Projects: GA ČR(CZ) GA524/06/0517
Grant - others:GA ČR(CZ) GA524/09/1337
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : polychlorinated biphenyls * E-cadherin * beta-catenin
Subject RIV: BO - Biophysics
Impact factor: 3.241, year: 2009
Permanent Link: http://hdl.handle.net/11104/0173940 - 8.0318647 - BFÚ 2009 RIV US eng J - Journal Article
Šimečková, P. - Vondráček, Jan - Andrysík, Zdeněk - Zatloukalová, Jiřina - Krčmář, P. - Kozubík, Alois - Machala, M.
The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities.
[2,2',4,4',5,5'-hexachlorobifenyl (PCB 153) posiluje degradaci konexinu43 prostřednictvím proteazomálních a lysozomálních aktivit.]
Toxicological Sciences. Roč. 107, č. 1 (2009), s. 9-18. ISSN 1096-6080. E-ISSN 1096-0929
R&D Projects: GA ČR(CZ) GA524/06/0517
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : PCBs * connexin * gap junctions
Subject RIV: BO - Biophysics
Impact factor: 4.814, year: 2009
Permanent Link: http://hdl.handle.net/11104/0168005 - 9.0307007 - BFÚ 2008 RIV NL eng J - Journal Article
Machala, M. - Šindlerová, Lenka - Pěnčíková, K. - Krčmář, P. - Topinka, Jan - Milcová, Alena - Nováková, Zuzana - Kozubík, Alois - Vondráček, Jan
Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells.
[Účinky methylovaných derivátů chrysenu na AhR-závislé a nezávislé toxické děje v jaterních epiteliálních buňkách potkana.]
Toxicology. Roč. 247, 2-3 (2008), s. 93-101. ISSN 0300-483X
R&D Projects: GA ČR(CZ) GA524/05/0595
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : methylated chrysenes * aryl hydrocarbon receptor * genotoxicity
Subject RIV: BO - Biophysics
Impact factor: 2.836, year: 2008
Permanent Link: http://hdl.handle.net/11104/0159877 - 10.0306736 - BFÚ 2008 RIV US eng J - Journal Article
Marvanová, S. - Vondráček, Jan - Pěnčíková, K. - Trilecová, L. - Krčmář, P. - Topinka, Jan - Nováková, Zuzana - Milcová, Alena - Machala, M.
Toxic effects of methylated benz[a]janthracenes in liver cells.
[Toxické účinky metylovaných benz[a]janthracenů v jaterních buňkách.]
Chemical Research in Toxicology. Roč. 21, č. 2 (2008), s. 503-512. ISSN 0893-228X. E-ISSN 1520-5010
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390703
Keywords : Ah receptor * gap junctional intercellular communication * methylated PAHs
Subject RIV: BO - Biophysics
Impact factor: 3.491, year: 2008
Permanent Link: http://hdl.handle.net/11104/0159684