Search results
- 1.0584024 - ÚOCHB 2025 RIV US eng J - Journal Article
Selicharová, Irena - Fabre, Benjamin - Garre Hernández, María Soledad - Lubos, Marta - Pícha, Jan - Voburka, Zdeněk - Mitrová, Katarína - Jiráček, Jiří
Combinatorial libraries of bipodal binders of the insulin receptor.
ChemMedChem. (2024), e202400145. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : insulin * receptor * library * scaffold * peptide * combinatorial chemistry
OECD category: Medicinal chemistry
Impact factor: 3.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/cmdc.202400145
Permanent Link: https://hdl.handle.net/11104/0352016File Download Size Commentary Version Access 10.1002cmdc.202400145.pdf 0 1.1 MB Publisher’s postprint open-access - 2.0577780 - ÚOCHB 2024 RIV GB eng J - Journal Article
Kertisová, Anna - Žáková, Lenka - Macháčková, Kateřina - Marek, Aleš - Šácha, Pavel - Pompach, Petr - Jiráček, Jiří - Selicharová, Irena
Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation.
Open Biology. Roč. 13, č. 11 (2023), č. článku 230142. E-ISSN 2046-2441
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA22-17978S; GA MŠMT(CZ) EF18_046/0015974; GA MŠMT LM2023042
Institutional support: RVO:61388963 ; RVO:86652036
Keywords : mutagenesisin vitro * peptide hormone * eceptor modification * eceptor tyrosine kinase * structure–function
OECD category: Biochemistry and molecular biology
Impact factor: 5.8, year: 2022
Method of publishing: Open access
https://doi.org/10.1098/rsob.230142
Permanent Link: https://hdl.handle.net/11104/0346886File Download Size Commentary Version Access 10.1098rsob.230142.pdf 2 2 MB Publisher’s postprint open-access - 3.0574400 - ÚOCHB 2024 RIV GB eng J - Journal Article
Potalitsyn, Pavlo - Mrázková, Lucie - Selicharová, Irena - Tencerová, Michaela - Ferenčáková, Michaela - Chrudinová, Martina - Turnovská, Tereza - Brzozowski, A. M. - Marek, Aleš - Kaminský, Jakub - Jiráček, Jiří - Žáková, Lenka
Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2.
Communications Biology. Roč. 6, č. 1 (2023), č. článku 863. E-ISSN 2399-3642
R&D Projects: GA ČR(CZ) GA19-14069S; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : hormone * prohormone * precursor * mitogenic * receptor * IGF
OECD category: Biochemistry and molecular biology
Impact factor: 5.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1038/s42003-023-05239-6
Permanent Link: https://hdl.handle.net/11104/0344735File Download Size Commentary Version Access 10.1038s42003-023-05239-6.pdf 1 2.1 MB Publisher’s postprint open-access - 4.0570637 - ÚOCHB 2024 RIV US eng J - Journal Article
Lin, Jingjing - Asai, Seiya - Selicharová, Irena - Mitrová, Katarína - Kaminský, Jakub - Young, E. - Jiráček, Jiří
Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities.
International Journal of Peptide Research and Therapeutics. Roč. 29, č. 2 (2023), č. článku 33. ISSN 1573-3149. E-ISSN 1573-3904
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : IGF-1 * receptor * dimer * insulin * binding * phosphorylation * hormone * folding * agonism * antagonism
OECD category: Biochemistry and molecular biology
Impact factor: 2.5, year: 2022
Method of publishing: Open access
https://doi.org/10.1007/s10989-023-10499-1
Permanent Link: https://hdl.handle.net/11104/0341946File Download Size Commentary Version Access 10.1007s10989-023-10499-1.pdf 0 1.2 MB Publisher’s postprint open-access - 5.0567614 - ÚOCHB 2024 RIV GB eng J - Journal Article
Lubos, Marta - Pícha, Jan - Selicharová, Irena - Žák, Jiří - Buděšínský, Miloš - Mitrová, Katarína - Žáková, Lenka - Jiráček, Jiří
Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications.
Journal of Peptide Science. Roč. 29, č. 7 (2023), č. článku e3478. ISSN 1075-2617. E-ISSN 1099-1387
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : antagonism * dicarba * disulfide mimetics * insulin mimetic peptide * insulin receptor * staple * triazole
OECD category: Biochemistry and molecular biology
Impact factor: 2.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/psc.3478
Permanent Link: https://hdl.handle.net/11104/0338851File Download Size Commentary Version Access 10.1002psc.3478.pdf 2 1.1 MB Publisher’s postprint open-access - 6.0566032 - ÚOCHB 2023 RIV GB eng J - Journal Article
Asai, Seiya - Moravcová, J. - Žáková, Lenka - Selicharová, Irena - Hadravová, Romana - Brzozowski, A. M. - Nováček, J. - Jiráček, Jiří
Characterization of insulin crystalline form in isolated β-cell secretory granules.
Open Biology. Roč. 12, č. 12 (2022), č. článku 220322. E-ISSN 2046-2441
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:61388963
Keywords : insulin secretory granules * protein crystals * in vivo crystalization * cryo-EM
OECD category: Cell biology
Impact factor: 5.8, year: 2022
Method of publishing: Open access
https://doi.org/10.1098/rsob.220322
Permanent Link: https://hdl.handle.net/11104/0337471 - 7.0564527 - ÚOCHB 2024 RIV GB eng J - Journal Article
Lin, Jingjing - Selicharová, Irena - Mitrová, Katarína - Fabre, Benjamin - Miriyala, Vijay Madhav - Lepšík, Martin - Jiráček, Jiří - Garre Hernández, María Soledad
Targeting the insulin receptor with hormone and peptide dimers.
Journal of Peptide Science. Roč. 29, č. 4 (2023), č. článku e3461. ISSN 1075-2617. E-ISSN 1099-1387
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : insulin * dimer * bioconjugate * agonism * antagonism * peptidomimetics * receptor * peptide hormone
OECD category: Biochemistry and molecular biology
Impact factor: 2.1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/psc.3461
Permanent Link: https://hdl.handle.net/11104/0336187 - 8.0546413 - ÚOCHB 2022 RIV US eng J - Journal Article
Páníková, Terezie - Mitrová, Katarína - Halamová, Tereza - Mrzílková, Karolína - Pícha, Jan - Chrudinová, Martina - Kurochka, Andrii - Selicharová, Irena - Žáková, Lenka - Jiráček, Jiří
Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities.
Journal of Medicinal Chemistry. Roč. 64, č. 19 (2021), s. 14848-14859. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : insulin * hepatoselective * stability
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01388
Permanent Link: http://hdl.handle.net/11104/0322932 - 9.0543107 - ÚOCHB 2022 RIV DE eng J - Journal Article
Asai, Seiya - Žáková, Lenka - Selicharová, Irena - Marek, Aleš - Jiráček, Jiří
A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.
Analytical and Bioanalytical Chemistry. Roč. 413, č. 17 (2021), s. 4531-4543. ISSN 1618-2642. E-ISSN 1618-2650
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : binding assay * insulin receptor * insulin secretion * radioligand * secretagogue * β Cells
OECD category: Biochemistry and molecular biology
Impact factor: 4.478, year: 2021
Method of publishing: Limited access
https://doi.org/10.1007/s00216-021-03423-3
Permanent Link: http://hdl.handle.net/11104/0320393 - 10.0533335 - ÚOCHB 2021 RIV GB eng J - Journal Article
Dzianová, P. - Asai, Seiya - Chrudinová, Martina - Kosinová, L. - Potalitsyn, Pavlo - Šácha, Pavel - Hadravová, Romana - Selicharová, Irena - Kříž, J. - Turkenburg, J. P. - Brzozowski, A. M. - Jiráček, Jiří - Žáková, Lenka
The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels.
Open Biology. Roč. 10, č. 10 (2020), č. článku 200137. E-ISSN 2046-2441
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : insulin * zinc * beta cells * production ZnT8
OECD category: Biochemistry and molecular biology
Impact factor: 6.411, year: 2020
Method of publishing: Open access
https://doi.org/10.1098/rsob.200137
Permanent Link: http://hdl.handle.net/11104/0311840