Search results
- 1.0564352 - MBÚ 2023 RIV DE eng J - Journal Article
Bereczki, I. - Vimberg, Vladimír - Lorincz, E. - Papp, H. - Nagy, L. - Keki, S. - Batta, G. - Mitrović, A. - Kos, J. - Zsigmond, A. - Hajdú, I. - Lőrincz, Z. - Bajusz, D. - Petri, L. - Hodek, Jan - Jakab, F. - Keserű, G. M. - Weber, Jan - Naesens, L. - Herczegh, P. - Borbas, A.
Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria.
Scientific Reports. Roč. 12, č. 1 (2022), č. článku 16001. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388971 ; RVO:61388963
Keywords : glycopeptide * virus * inhibitors * pseudoaglycon * dimerization * vancomycin * protease * binding
OECD category: Microbiology; Virology (UOCHB-X)
Impact factor: 4.6, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41598-022-20182-y
Permanent Link: https://hdl.handle.net/11104/0336026 - 2.0563497 - ÚOCHB 2023 RIV CH eng J - Journal Article
Bege, M. - Kiss, A. - Bereczki, I. - Hodek, Jan - Polyák, L. - Szemán-Nagy, G. - Naesens, L. - Weber, Jan - Borbás, A.
Synthesis and Anticancer and Antiviral Activities of C-2'-Branched Arabinonucleosides.
International Journal of Molecular Sciences. Roč. 23, č. 20 (2022), č. článku 12566. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : photocatalytic thiol-ene reaction * nucleoside analogue * anti-tumor * time-lapse imaging * antiviral * coronavirus * SARS-CoV-2
OECD category: Virology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms232012566
Permanent Link: https://hdl.handle.net/11104/0335456File Download Size Commentary Version Access 10.3390ijms232012566.pdf 5 3.5 MB Publisher’s postprint open-access - 3.0542267 - ÚOCHB 2022 RIV US eng J - Journal Article
Keough, D. T. - Wun, J. S. - Baszczyňski, Ondřej - Eng, W. S. - Špaček, Petr - Panjikar, S. - Naesens, L. - Pohl, Radek - Rejman, Dominik - Hocková, Dana - Ferrero, R. L. - Guddat, L. W.
Helicobacter pylori Xanthine–Guanine–Hypoxanthine Phosphoribosyltransferase—A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
Journal of Medicinal Chemistry. Roč. 64, č. 9 (2021), s. 5710-5729. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : XGHPRT * inhibitor * phosphonate * nucleotide
OECD category: Organic chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.0c02184
Permanent Link: http://hdl.handle.net/11104/0319726 - 4.0479744 - ÚOCHB 2018 RIV US eng J - Journal Article
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
Journal of Medicinal Chemistry. Roč. 60, č. 17 (2017), s. 7539-7554. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : hypoxanthine-guanine phosphoribosyltransferase * 2nd phosphonate group * 6-oxopurine phosphoribosyltransferases
OECD category: Organic chemistry
Impact factor: 6.253, year: 2017
Permanent Link: http://hdl.handle.net/11104/0275689 - 5.0477558 - ÚOCHB 2018 RIV GB eng J - Journal Article
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs.
Bioorganic & Medicinal Chemistry. Roč. 25, č. 15 (2017), s. 4008-4030. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * nucleotide analogues * malaria
OECD category: Organic chemistry
Impact factor: 2.881, year: 2017
Permanent Link: http://hdl.handle.net/11104/0273877 - 6.0469893 - ÚOCHB 2017 RIV DE eng J - Journal Article
Eng, W. S. - Hocková, Dana - Špaček, Petr - Baszczyňski, Ondřej - Janeba, Zlatko - Naesens, L. - Keough, D. T. - Guddat, L. W.
Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase.
ChemistrySelect. Roč. 1, č. 19 (2016), s. 6267-6276. ISSN 2365-6549. E-ISSN 2365-6549
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * nucleotide analogues * HPRT
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0267662 - 7.0465607 - ÚOCHB 2017 RIV GB eng J - Journal Article
Terán, D. - Hocková, Dana - Česnek, Michal - Zíková, Alena - Naesens, L. - Keough, D. T. - Guddat, L. W.
Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.
Scientific Reports. Roč. 6, Oct 27 (2016), č. článku 35894. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : enzyme inhibitors * acyclic nucleoside phosphonates * HGPRT
Subject RIV: CC - Organic Chemistry; EE - Microbiology, Virology (BC-A)
Impact factor: 4.259, year: 2016
http://www.nature.com/articles/srep35894
Permanent Link: http://hdl.handle.net/11104/0264085 - 8.0461337 - ÚOCHB 2017 RIV US eng J - Journal Article
Topalis, D. - Nogueira, T. C. - De Schutter, T. - El Amri, C. - Krečmerová, Marcela - Naesens, L. - Balzarini, J. - Andrei, G. - Snoeck, R.
Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1.
OncoTarget. Roč. 7, č. 9 (2016), s. 10386-10401. ISSN 1949-2553
R&D Projects: GA ČR(CZ) GA14-00522S
Institutional support: RVO:61388963
Keywords : human papillomavirus * cervical carcinoma * UMP-CMP kinase * cidofovir * NTP metabolism
Subject RIV: CC - Organic Chemistry
Impact factor: 5.168, year: 2016
Permanent Link: http://hdl.handle.net/11104/0260954 - 9.0448335 - ÚOCHB 2016 RIV GB eng J - Journal Article
Hocková, Dana - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Chavchich, M. - Keough, D. T. - Guddat, L. W.
Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.
Bioorganic & Medicinal Chemistry. Roč. 23, č. 17 (2015), s. 5502-5510. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR GAP207/11/0108
Institutional support: RVO:61388963
Keywords : nucleotide analogues * enzyme inhibitors * malaria * HG(X)PRT * ANP
Subject RIV: CC - Organic Chemistry
Impact factor: 2.923, year: 2015
Permanent Link: http://hdl.handle.net/11104/0250073 - 10.0443295 - ÚOCHB 2016 RIV US eng J - Journal Article
Keough, D. T. - Hocková, Dana - Janeba, Zlatko - Wang, T. H. - Naesens, L. - Edstein, M. D. - Chavchich, M. - Guddat, L. W.
Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
Journal of Medicinal Chemistry. Roč. 58, č. 2 (2015), s. 827-846. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0108
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * ANPs * Plasmodium * malaria
Subject RIV: CC - Organic Chemistry
Impact factor: 5.589, year: 2015
Permanent Link: http://hdl.handle.net/11104/0246076