Search results
- 1.0189173 - UMCH-V 20033128 RIV US eng J - Journal Article
Skálová, Tereza - Hašek, Jindřich - Dohnálek, Jan - Petroková, Hana - Buchtelová, Eva - Dušková, Jarmila - Souček, Milan - Majer, Pavel - Kondrová, Taťána - Konvalinka, Jan
An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study.
Journal of Medicinal Chemistry. Roč. 46, č. 9 (2003), s. 1636-1644. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA AV ČR IAA4050811; GA AV ČR KJB4050312; GA ČR GV203/98/K023; GA ČR GA204/00/P091; GA ČR GA203/00/D117; GA MZd NI6339
Institutional research plan: CEZ:AV0Z4050913; CEZ:AV0Z4055905
Keywords : mutant HIV-1 protease * ethylenamine inhibitor * structure
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.820, year: 2003
Permanent Link: http://hdl.handle.net/11104/0085014 - 2.0105718 - UMCH-V 20043288 RIV GB eng J - Journal Article
Petroková, Hana - Dušková, Jarmila - Dohnálek, Jan - Skálová, Tereza - Vondráčková-Buchtelová, Eva - Souček, Milan - Konvalinka, Jan - Brynda, Jiří - Fábry, Milan - Sedláček, Juraj - Hašek, Jindřich
Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors.
[Role hydroxylové skupiny a R/S konfigurace izosteru na vazební vlastnosti inhibitorů HIV-1 proteázy.]
European Journal of Biochemistry. Roč. 271, č. 22 (2004), s. 4451-4461. ISSN 0014-2956
R&D Projects: GA AV ČR KJB4050312
Keywords : ethyleneamine inhibitor * HIV-1 protease * peptidomimetic inhibitor
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 3.260, year: 2004
Permanent Link: http://hdl.handle.net/11104/0012929 - 3.0044922 - ÚMCH 2007 RIV US eng J - Journal Article
Skálová, Tereza - Dohnálek, Jan - Dušková, Jarmila - Petroková, Hana - Hradilek, Martin - Souček, Milan - Konvalinka, Jan - Hašek, Jindřich
HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site.
[Mutace HIV-1 proteázy a modifikace jejího inhibitoru sledované na sérii komplexů. Strukturní podklady pro efekt mutace A71V na aktivní místo.]
Journal of Medicinal Chemistry. Roč. 49, č. 19 (2006), s. 5777-5784. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA AV ČR KJB4050312; GA MŠMT 1K05008; GA AV ČR IAA4050811
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z40550506
Keywords : HIV-1 protease * protein crystallography * drug design
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.115, year: 2006
Permanent Link: http://hdl.handle.net/11104/0137592 - 4.0040944 - ÚMCH 2007 RIV CZ eng J - Journal Article
Hašek, Jindřich - Skálová, Tereza - Dohnálek, Jan - Dušková, Jarmila - Petroková, Hana - Vondráčková, Eva - Zimmermann, K.
Drug design based on x-ray diffraction and steered molecular dynamics.
[Vývoj nových léčiv na základě difrakčních měření a řízené molekulární dynamiky.]
Materials Structure in Chemistry, Biology, Physics and Technology. Roč. 12, č. 3 (2005), s. 208-210. ISSN 1211-5894.
[VUFB Conference on Modern Methods in Synthesis and Analysis of Active Pharmaceutical Substances /5./. Praha, 23.11.2005-24.11.2005]
R&D Projects: GA AV ČR KJB4050312
Institutional research plan: CEZ:AV0Z40500505
Keywords : drug design * X-ray diffraction * steered molecular dynamics
Subject RIV: CF - Physical ; Theoretical Chemistry
Permanent Link: http://hdl.handle.net/11104/0134552 - 5.0040930 - ÚMCH 2007 RIV DK eng J - Journal Article
Dušková, Jarmila - Dohnálek, Jan - Skálová, Tereza - Petroková, Hana - Vondráčková, Eva - Hradilek, Martin - Konvalinka, Jan - Souček, Milan - Brynda, Jiří - Fábry, Milan - Sedláček, Juraj - Hašek, Jindřich
On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 angstrom resolution.
[Význam R konfigurace isosteru reakčního intermediátu pro vazbu HIV-1 proteasa-inhibitor: rentgenová struktura s rozlišením 2.0 A.]
Acta Crystallographica Section D-Biological Crystallography. Roč. 62, 5-6 (2006), s. 489-497. ISSN 0907-4449
R&D Projects: GA AV ČR KJB4050312
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : human immunodeficiency virus-1 * protease * inhibitor
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 1.687, year: 2006
Permanent Link: http://hdl.handle.net/11104/0003622