Search results
- 1.0427735 - ÚOCHB 2015 RIV US eng J - Journal Article
Grantz Šašková, Klára - Kožíšek, Milan - Stray, K. - Jong de, D. - Řezáčová, Pavlína - Brynda, Jiří - Maarseveen van, N. M. - Nijhuis, M. - Cihlář, T. - Konvalinka, Jan
GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions.
Journal of Virology. Roč. 88, č. 6 (2014), s. 3586-3590. ISSN 0022-538X. E-ISSN 1098-5514
R&D Projects: GA ČR GAP207/11/1798
Grant - others:OPPC(XE) CZ.2.16/3.1.00/24016
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : virus type-1 protease * antiviral activity * drug resistance
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.439, year: 2014
Permanent Link: http://hdl.handle.net/11104/0233311 - 2.0377476 - ÚOCHB 2013 RIV GB eng J - Journal Article
Maarseveen van, N. M. - Andersson, Dan - Lepšík, Martin - Fun, A. - Schipper, P. J. - Jong de, D. - Boucher, Ch. A. B. - Nijhuis, M.
Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity.
Retrovirology. Roč. 9, č. 29 (2012), s. 1-7. E-ISSN 1742-4690
EU Projects: European Commission(XE) 37693 - HIV PI RESISTANCE
Grant - others:Dutch AIDS Fund(XE) 2006028; (NWO) VIDI(XE) 91796349
Institutional research plan: CEZ:AV0Z40550506
Keywords : HIV-1 * protease * Gag * resistance * cleavage
Subject RIV: CE - Biochemistry
Impact factor: 5.657, year: 2012
Permanent Link: http://hdl.handle.net/11104/0209622 - 3.0370143 - ÚOCHB 2012 RIV GB eng J - Journal Article
Fun, A. - Maarseveen van, N. M. - Pokorná, Jana - Maas, R. E. - Schipper, P. J. - Konvalinka, Jan - Nijhuis, M.
HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.
Retrovirology. Roč. 8, č. 70 (2011), s. 1-12. E-ISSN 1742-4690
Grant - others:European Union(XE) LWSHP-CT-2007-037693
Institutional research plan: CEZ:AV0Z40550506
Keywords : immunodeficiency-virus type-1 * gag spacer peptide-1 * replication capacity * compensatory mutations * cleavage sites
Subject RIV: CE - Biochemistry
Impact factor: 6.470, year: 2011
Permanent Link: http://hdl.handle.net/11104/0204028 - 4.0312664 - ÚOCHB 2009 RIV US eng J - Journal Article
Kožíšek, Milan - Grantz Šašková, Klára - Řezáčová, Pavlína - Brynda, Jiří - Maarseveen van, N. M. - De Jongh, D. - Boucher, Ch. A. B. - Kagan, R. M. - Nijhuis, M. - Konvalinka, Jan
Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region.
[Devadesát devět není dost : molekulární charakterizace resistentních mutantů HIV-1 proteasy s inzercemi v oblasti chlopní.]
Journal of Virology. Roč. 82, č. 12 (2008), s. 5869-5878. ISSN 0022-538X. E-ISSN 1098-5514
R&D Projects: GA MŠMT 1M0508; GA MZd NR8571
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : HIV protease inhibitors * aspartic proteases * viral resistance * insertions
Subject RIV: CE - Biochemistry
Impact factor: 5.308, year: 2008
Permanent Link: http://hdl.handle.net/11104/0163665 - 5.0084111 - ÚOCHB 2008 RIV US eng J - Journal Article
Nijhuis, M. - Maarseveen van, N. M. - Lastere, S. - Schipper, P. - Coakley, E. - Glass, B. - Rovenská, Miroslava - Jong de, D. - Chappey, C. - Goedegebuure, I. W. - Heilek-Snyder, G. - Dulude, D. - Cammack, N. - Brakier-Gingras, L. - Konvalinka, Jan - Parkin, N. - Kräusslich, H. G. - Brun-Vezinet, F. - Boucher, Ch. A. B.
A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism.
[Nový mechanismus vzniku rezistence vůči inhibitorům proteasy HIV-1 založený na substrátu.]
PLoS MEDICINE. Roč. 4, č. 1 (2007), s. 152-163. ISSN 1549-1277. E-ISSN 1549-1676
Institutional research plan: CEZ:AV0Z40550506
Keywords : HIV-1 protease * drug resistance * protease inhibitor
Subject RIV: CE - Biochemistry
Impact factor: 12.601, year: 2007
Permanent Link: http://hdl.handle.net/11104/0147122