Search results
- 1.0585334 - FGÚ 2025 RIV GB eng J - Journal Article
Honzejková, K. - Košek, Dalibor - Obšilová, Veronika - Obšil, Tomáš
The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1.
eLife. Roč. 13, Mar 27 (2024), č. článku RP95199. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB III - 90242
Institutional support: RVO:67985823
Keywords : MAP3K * ASK1 kinase * Thioredoxin * cryo-EM
OECD category: Biochemistry and molecular biology
Impact factor: 7.7, year: 2022
Method of publishing: Open access
https://doi.org/10.7554/eLife.95199.2
Permanent Link: https://hdl.handle.net/11104/0353047 - 2.0533796 - ÚOCHB 2021 US eng A - Abstract
Obšil, T. - Pšenáková, K. - Hexnerová, Rozálie - Srb, Pavel - Obšilová, Veronika - Veverka, Václav
Structural Characterization of the Apoptosis Signal‐regulating Kinase 1 (ASK1) Domain Responsible for Thioredoxin Binding and its Complex.
FASEB Journal. Wiley. Roč. 34, S1 (2020). ISSN 0892-6638. E-ISSN 1530-6860.
[Annual Meeting on Experimental Biology. 04.04.2020-07.04.2020, San Diego]
R&D Projects: GA ČR(CZ) GA19-00121S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : ASK1 * thioredoxin
OECD category: Biochemistry and molecular biology
https://doi.org/10.1096/fasebj.2020.34.s1.03959
Permanent Link: http://hdl.handle.net/11104/0312434 - 3.0524243 - FGÚ 2021 RIV GB eng J - Journal Article
Pšenáková, Katarína - Hexnerová, Rozálie - Srb, Pavel - Obšilová, Veronika - Veverka, Václav - Obšil, Tomáš
The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress.
FEBS Journal. Roč. 287, č. 8 (2020), s. 1626-1644. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA ČR(CZ) GA19-00121S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : apoptosis signal-regulating kinase 1 * mitogen‐activated protein kinase kinase kinase * oxidative stress * protein–protein interaction * thioredoxin
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 5.542, year: 2020
Method of publishing: Limited access
https://doi.org/10.1111/febs.15101
Permanent Link: http://hdl.handle.net/11104/0308627 - 4.0506675 - BFÚ 2020 RIV DE eng J - Journal Article
Muenzner, J.K. - Biersack, B. - Albrecht, A. - Rehm, T. - Lacher, U. - Milius, W. - Casini, A. - Zhang, J.J. - Ott, I. - Brabec, Viktor - Stuchlikova, O. - Andronache, I.C. - Kaps, L. - Schuppan, D. - Schobert, R.
Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs.
Chemistry - A European Journal. Roč. 22, č. 52 (2016), s. 18953-18962. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA ČR(CZ) GA14-21053S
Institutional support: RVO:68081707
Keywords : thioredoxin reductase inhibitors * chorioallantoic membrane model * potential anticancer * cancer cells
OECD category: Analytical chemistry
Impact factor: 5.317, year: 2016
Method of publishing: Open access
http://orca.cf.ac.uk/95519/1/chem%20201604246_final%20manuscript.pdf
Permanent Link: http://hdl.handle.net/11104/0297875 - 5.0487591 - FGÚ 2018 RIV NL eng J - Journal Article
Obšil, Tomáš - Obšilová, Veronika
Structural aspects of protein kinase ASK1 regulation.
Advances in Biological Regulation. Roč. 66, 1 Dec (2017), s. 31-36. ISSN 2212-4926
R&D Projects: GA ČR(CZ) GA16-02739S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823
Keywords : ASK1 kinase * apoptosis * thioredoxin * 14-3-3 protein
OECD category: Biochemistry and molecular biology
Permanent Link: http://hdl.handle.net/11104/0282245 - 6.0486052 - BFÚ 2018 RIV US eng J - Journal Article
Lemmerhirt, H. - Behnisch, S. - Bodtke, A. - Lillig, Ch.H. - Pazderová, L. - Kašpárková, Jana - Brabec, Viktor - Bednarski, P.J.
Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA.
Journal of Inorganic Biochemistry. Roč. 178, JAN2018 (2018), s. 94-105. ISSN 0162-0134. E-ISSN 1873-3344
R&D Projects: GA ČR GA17-09436S
Institutional support: RVO:68081707
Keywords : glutathione-peroxidase * thioredoxin reductase
OECD category: Biochemistry and molecular biology
Impact factor: 3.224, year: 2018
Permanent Link: http://hdl.handle.net/11104/0280940 - 7.0476384 - ÚOCHB 2018 CZ eng A - Abstract
Pšenáková, K. - Veverka, Václav - Hexnerová, Rozálie - Srb, Pavel - Kylarová, Salome - Obšilová, Veronika - Obšil, T.
Structural characterization of protein kinase ASK1 and its interaction with thioredoxin.
32nd NMR Valtice. Central European NMR Meeting. Valtice: Stuare, 2017 - (Novotný, J.; Marek, R.). C10. ISBN 978-80-86441-49-8.
[NMR Valtice. Central European NMR Meeting /32./. 23.04.2017-26.04.2017, Valtice]
R&D Projects: GA ČR(CZ) GA14-10061S
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : ASK1 * thioredoxin
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0272895 - 8.0452109 - ÚOCHB 2016 GB eng A - Abstract
Koháryová, M. - Brynda, Jiří - Řezáčová, Pavlína - Kollárová, M.
Thioredoxin reductase from s. Coelicolor as a drug target.
FEBS Journal. Roč. 282, Suppl 1 (2015), s. 396. ISSN 1742-464X. E-ISSN 1742-4658.
[Congress of the Federation of European Biochemical Societies (FEBS) - The Biochemical Basis of Life /40./. 04.07.2015-09.07.2015, Berlin]
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : thioredoxin reductase * protein structure * drugs
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0253136 - 9.0432569 - FGÚ 2015 RIV US eng J - Journal Article
Košek, Dalibor - Kylarová, Salome - Pšenáková, Katarína - Řežábková, L. - Herman, P. - Večeř, J. - Obšilová, Veronika - Obšil, T.
Biophysical and Structural Characterization of the Thioredoxin-binding Domain of Protein Kinase ASK1 and Its Interaction with Reduced Thioredoxin.
Journal of Biological Chemistry. Roč. 289, č. 35 (2014), s. 24463-24474. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA ČR(CZ) GA14-10061S
Institutional support: RVO:67985823
Keywords : ASK1 * thioredoxin * AUC * SAXS * coiled-coiled domain
Subject RIV: CE - Biochemistry
Impact factor: 4.573, year: 2014
Permanent Link: http://hdl.handle.net/11104/0237144 - 10.0429470 - ÚOCHB 2015 RIV US eng J - Journal Article
Machová, Iva - Snášel, Jan - Zimmermann, M. - Laubitz, D. - Plocinski, P. - Oehlmann, W. - Singh, M. - Dostál, Jiří - Sauer, U. - Pichová, Iva
Mycobacterium tuberculosis Phosphoenolpyruvate Carboxykinase Is Regulated by Redox Mechanisms and Interaction with Thioredoxin.
Journal of Biological Chemistry. Roč. 289, č. 19 (2014), s. 13066-13078. ISSN 0021-9258. E-ISSN 1083-351X
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Grant - others:OPPK(CZ) CZ.2.16/3.1.00/24016
Institutional support: RVO:61388963
Keywords : enzyme kinetics * hypoxia * metabolism * Mycobacterium tuberculosis * oxidation-reduction * thioredoxin * Phosphoenolpyruvate carboxykinase
Subject RIV: CE - Biochemistry
Impact factor: 4.573, year: 2014
Permanent Link: http://hdl.handle.net/11104/0234607