Search results
- 1.0541460 - ÚOCHB 2022 RIV US eng J - Journal Article
Milisavljevič, Nemanja - Konkoľová, Eva - Kozák, Jaroslav - Hodek, Jan - Veselovská, Lucia - Sýkorová, Veronika - Čížek, Karel - Pohl, Radek - Eyer, Luděk - Svoboda, P. - Růžek, Daniel - Weber, Jan - Nencka, Radim - Bouřa, Evžen - Hocek, Michal
Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses.
ACS Infectious Diseases. Roč. 7, č. 2 (2021), s. 471-478. ISSN 2373-8227
R&D Projects: GA ČR(CZ) GA19-08124S; GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LTAUSA18016; GA MŠMT(CZ) EF16_019/0000729
Grant - others:AV ČR(CZ) AP1501
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : 7-deazapurine ribonucleosides * monophosphate prodrugs * triphoshates * RNA viruses * 7-deazapurine ribonucleosides monophosphate prodrugs triphoshates RNA viruses antiviral activity
OECD category: Organic chemistry; Biochemistry and molecular biology (BC-A)
Impact factor: 5.578, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acsinfecdis.0c00829
Permanent Link: http://hdl.handle.net/11104/0319010 - 2.0532766 - ÚOCHB 2021 RIV DE eng J - Journal Article
Veselovská, Lucia - Kudlová, N. - Gurská, S. - Lišková, B. - Medvedíková, M. - Hodek, Ondřej - Tloušťová, Eva - Milisavljevič, Nemanja - Tichý, Michal - Perlíková, Pavla - Mertlíková-Kaiserová, Helena - Trylčová, Jana - Pohl, Radek - Klepetářová, Blanka - Džubák, P. - Hajdúch, M. - Hocek, Michal
Synthesis and Cytotoxic and Antiviral Activity Profiling of All-Four Isomeric Series of Pyrido-Fused 7-Deazapurine Ribonucleosides.
Chemistry - A European Journal. Roč. 26, č. 57 (2020), s. 13002-13015. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA ČR(CZ) GA19-08124S; GA MZd(CZ) NV15-31984A; GA MŠMT(CZ) LM2015064
Grant - others:AV ČR(CZ) AP1501
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:61388963
Keywords : antitumor agents * antiviral agents * drug discovery * phosphorylation * ribonucleosides
OECD category: Organic chemistry
Impact factor: 5.236, year: 2020
Method of publishing: Limited access
https://doi.org/10.1002/chem.202001124
Permanent Link: http://hdl.handle.net/11104/0311179 - 3.0485403 - ÚOCHB 2018 CZ eng A - Abstract
Tokarenko, Anna - Hocek, Michal
Synthesis of pyrrolo-fused 7-deazapurine ribonucleosides.
Liblice 2017. 52nd Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2017. s. 122.
[Liblice 2017. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /52./. 03.11.2017-05.11.2017, Lázně Bělohrad]
R&D Projects: GA ČR(CZ) GA16-00178S
Institutional support: RVO:61388963
Keywords : deazapurine synthesis * ribonucleosides
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0280605 - 4.0484675 - ÚOCHB 2018 RIV eng P - Patent Document
Hocek, Michal - Nauš, Petr - Caletková, Olga - Hajdúch, M. - Džubák, P.
Substituted 7-deazapurine ribonucleosides for therapeutic uses.
2017. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Date of the patent acceptance: 07.03.2017. Patent Number: US9586986
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR GAP207/11/0344
Institutional support: RVO:61388963
Keywords : substituted 7-deazapurine ribonucleosides * cytostatic activity
OECD category: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=9586986B2&KC=B2&FT=D&ND=4&date=20170307&DB=&locale=en_EP#
Permanent Link: http://hdl.handle.net/11104/0281420 - 5.0480133 - ÚOCHB 2018 RIV GB eng J - Journal Article
Konč, Juraj - Tichý, Michal - Pohl, Radek - Hodek, Jan - Džubák, P. - Hajdúch, M. - Hocek, Michal
Sugar modified pyrimido[4,5-b] indole nucleosides: synthesis and antiviral activity.
MedChemComm. Roč. 8, č. 9 (2017), s. 1856-1862. ISSN 2040-2503. E-ISSN 2040-2511
R&D Projects: GA ČR(CZ) GA16-00178S
Grant - others:AV ČR(CZ) AP1501
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:61388963
Keywords : hepatitis C virus * modified derivatives * ribonucleosides
OECD category: Organic chemistry
Impact factor: 2.342, year: 2017
http://pubs.rsc.org/en/content/articlehtml/2017/md/c7md00319f
Permanent Link: http://hdl.handle.net/11104/0276042 - 6.0471699 - ÚOCHB 2017 RIV eng P - Patent Document
Hocek, Michal - Nauš, Petr - Caletková, Olga - Hajdúch, M. - Džubák, P.
Novel substituted 7-deazapurine ribonucleosides for therapeutic uses.
2016. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Date of the patent acceptance: 25.02.2016. Patent Number: AU2014277740
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR GAP207/11/0344
Institutional support: RVO:61388963
Keywords : substituted 7-deazapurine ribonucleosides * cytostatic activity
Subject RIV: CC - Organic Chemistry
https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20160225&CC=AU&NR=2014277740B1&KC=B1#
Permanent Link: http://hdl.handle.net/11104/0269481 - 7.0455859 - ÚOCHB 2016 RIV cze P - Patent Document
Hocek, Michal - Nauš, Petr - Caletková, Olga - Hajdúch, M. - Džubák, P.
Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití.
[Substituted 7-deazapurine ribonucleosides for therapeutic use.]
2015. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Date of the patent acceptance: 07.09.2015. Patent Number: 305466
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR GAP207/11/0344
Institutional support: RVO:61388963
Keywords : substituted 7-deazapurine ribonucleosides * cytostatic activity
Subject RIV: CC - Organic Chemistry
http://spisy.upv.cz/Patents/FullDocuments/305/305466.pdf
Permanent Link: http://hdl.handle.net/11104/0256462 - 8.0454134 - ÚOCHB 2016 RIV GB eng J - Journal Article
Nauš, Petr - Caletková, Olga - Perlíková, Pavla - Poštová Slavětínská, Lenka - Tloušťová, Eva - Hodek, Jan - Weber, Jan - Džubák, P. - Hajdúch, M. - Hocek, Michal
Synthesis and biological profiling of 6-or 7-(het)aryl-7-deazapurine 4 '-C-methylribonucleosides.
Bioorganic & Medicinal Chemistry. Roč. 23, č. 23 (2015), s. 7422-7438. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR GAP207/11/0344
Institutional support: RVO:61388963
Keywords : nucleosides * 4 '-C-methyl-ribonucleosides * branched nucleosides * nucleoside antivirals * prodrugs
Subject RIV: CC - Organic Chemistry
Impact factor: 2.923, year: 2015
Permanent Link: http://hdl.handle.net/11104/0254834 - 9.0436116 - ÚOCHB 2015 RIV US eng J - Journal Article
Snášel, Jan - Nauš, Petr - Dostál, Jiří - Hnízda, Aleš - Fanfrlík, Jindřich - Brynda, Jiří - Bourderioux, Aurelie - Dušek, Michal - Dvořáková, H. - Stolaříková, J. - Zábranská, Helena - Pohl, Radek - Konečný, P. - Džubák, P. - Votruba, Ivan - Hajdúch, M. - Řezáčová, Pavlína - Veverka, Václav - Hocek, Michal - Pichová, Iva
Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides.
Journal of Medicinal Chemistry. Roč. 57, č. 20 (2014), s. 8268-8279. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0344; GA MŠMT LO1302; GA MŠMT(CZ) LK11205
EU Projects: European Commission(XE) 241587 - SYSTEMTB
Grant - others:GA MŠk(CZ) LM2011020
Institutional support: RVO:61388963 ; RVO:68378271
Keywords : 7-(het)aryl-7-deazaadenine ribonucleosides * enzyme inhibition * adenosine kinase * cytostatic activity
Subject RIV: CC - Organic Chemistry
Impact factor: 5.447, year: 2014
Permanent Link: http://hdl.handle.net/11104/0239959 - 10.0429306 - ÚOCHB 2015 CZ eng C - Conference Paper (international conference)
Tichý, Michal - Hocek, Michal
Synthesis and biological activity of thiophene fused 7-deazapurine ribonucleosides.
Chemistry of Nucleic Acid Components. 16th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 - (Hocek, M.), s. 385-386. Collection Symposium Series, 14. ISBN 978-80-86241-50-0.
[Symposium on Chemistry of Nucleic Acid Components /16./. Český Krumlov (CZ), 08.06.2014-13.06.2014]
R&D Projects: GA ČR GAP207/11/0344
Institutional support: RVO:61388963
Keywords : nucleosides * cytostatics * 7-deazapurine ribonucleosides
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0234532