Search results
- 1.0586002 - ÚOCHB 2025 RIV US eng J - Journal Article
Spiwoková, Petra - Horn, Martin - Fanfrlík, Jindřich - Jílková, Adéla - Fajtová, Pavla - Leontovyč, Adrian - Houštecká, Radka - Bieliková, Lucia - Brynda, Jiří - Chanová, M. - Mertlíková-Kaiserová, Helena - Diaz-Caro, E. J. E. - Almaliti, J. - El Sakkary, N. - Gerwick, W. H. - Caffrey, C. R. - Mareš, Michael
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
ACS Infectious Diseases. (2024). ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LUAUS23050; GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine protease * drug target * parasite * Schistosoma mansoni * acrylamide inhibitor
Impact factor: 5.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.3c00589
Permanent Link: https://hdl.handle.net/11104/0353623 - 2.0585463 - ÚOCHB 2025 RIV GB eng J - Journal Article
Častorálová, M. - Sýs, Jakub - Prchal, J. - Pavlů, A. - Prokopová, L. - Briki, Z. - Hubálek, Martin - Ruml, T.
A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein.
eLife. Roč. 13, March (2024), č. článku e93489. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA ČR(CZ) GA22-19250S
Institutional support: RVO:61388963
Keywords : hiv-1 gag * type-1 gag * myristoyl switch * betaretrovirus * matrix protein * protease * maturation * Viruses
Impact factor: 7.7, year: 2022
Method of publishing: Open access
https://doi.org/10.7554/eLife.93489
Permanent Link: https://hdl.handle.net/11104/0353250File Download Size Commentary Version Access 10.7554eLife.93489.pdf 0 2.8 MB Publisher’s postprint open-access - 3.0585006 - MBÚ 2025 RIV NL eng J - Journal Article
Koník, Peter - Skotnicová, Petra - Gupta, Sadanand - Tichý, Martin - Sharma, Surbhi - Komenda, Josef - Sobotka, Roman - Krynická, Vendula
The cyanobacterial FtsH4 protease controls accumulation of protein factors involved in the biogenesis of photosystem I.
Biochimica Et Biophysica Acta-Bioenergetics. Roč. 1865, č. 1 (2024), č. článku 149017. ISSN 0005-2728. E-ISSN 1879-2650
R&D Projects: GA ČR(CZ) GX19-29225X; GA ČR(CZ) GJ19-08900Y
Institutional support: RVO:61388971
Keywords : synechocystis sp pcc-6803 * sp pcc 6803 * high-light * computational platform * iron-deficiency * quality-control * chlorophyll * complex * d1 * biosynthesis * FtsH4 protease * Synechocystis * Photosystem I * Thylakoid membrane * Assembly factors
OECD category: Microbiology
Impact factor: 4.3, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0005272823000634?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0352783 - 4.0584154 - BTÚ 2024 RIV CH eng M - Monography Chapter
Sur, Vishma Pratap - Sen, M. K. - Komrsková, Kateřina
In Silico Identification and Validation of Organic Triazole Based Ligands as Potential Inhibitory Drug Compounds of SARS-CoV-2 Main Protease.
Potential Anti-SARS-CoV-2 Molecular Strategies. Basel: MDPI, 2023 - (Roviello, G.; Vicidomini, C.), s. 125-139. ISBN 978-3-0365-6963-5
R&D Projects: GA MZd(CZ) NU20-03-00309; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : water * triazole * docking * main protease * SARS-CoV-2
OECD category: Biochemistry and molecular biology
https://mdpi-res.com/bookfiles/book/6951/Potential_AntiSARSCoV2_Molecular_Strategies.pdf?v=1709900388
Permanent Link: https://hdl.handle.net/11104/0352141 - 5.0582851 - ÚOCHB 2025 RIV CH eng J - Journal Article
Matoušková, Zuzana - Orsághová, Katarína - Srb, Pavel - Pytelková, Jana - Kukačka, Zdeněk - Buša, Michal - Hajdušek, Ondřej - Šíma, Radek - Fábry, Milan - Novák, Petr - Horn, Martin - Kopáček, Petr - Mareš, Michael
An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans.
International Journal of Molecular Sciences. Roč. 25, č. 4 (2024), č. článku 2240. ISSN 1661-6596
R&D Projects: GA ČR(CZ) GA21-08826S; GA ČR(CZ) GA22-27695S; GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA22-30920S; GA MŠMT(CZ) LUC23037
Institutional support: RVO:61388963 ; RVO:61388971 ; RVO:60077344
Keywords : cathepsin * cysteine protease * tick * parasite * saliva * thyropin * protease inhibitor * protein structure
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms25042240
Permanent Link: https://hdl.handle.net/11104/0350903 - 6.0581090 - ÚOCHB 2024 RIV heb P - Patent Document
Šimková, Adéla - Šácha, Pavel - Sidej, Natan - Ormsby, Tereza - Konvalinka, Jan
תרכובות לעיכוב חלבון הפעלת פיברובלסט.
[Compounds for inhibition of fibroblast activation protein.]
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 03.04.2023. Patent Number: IL295197. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA ČR(CZ) GA19-10280S; GA MZd(CZ) NV15-31379A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2015064; GA MZd(CZ) NU22-03-00318; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : FAP * protease * inhibition
OECD category: Medicinal chemistry
https://israelpatents.justice.gov.il/search/en/patent-extract/295197
Permanent Link: https://hdl.handle.net/11104/0349646File Download Size Commentary Version Access IL295197.pdf 1 202.4 KB Publisher’s postprint open-access - 7.0581089 - ÚOCHB 2024 RIV eng P - Patent Document
Šimková, Adéla - Šácha, Pavel - Sidej, Natan - Ormsby, Tereza - Konvalinka, Jan
Compounds for inhibition of fibroblast activation protein.
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 06.04.2023. Patent Number: AU2021248368. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA ČR(CZ) GA19-10280S; GA MZd(CZ) NV15-31379A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2015064; GA MZd(CZ) NU22-03-00318; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : FAP * protease * inhibition
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/075953813/publication/AU2021248368B2?q=AU2021248368B2
Permanent Link: https://hdl.handle.net/11104/0349645File Download Size Commentary Version Access AU2021248368B2.pdf 2 5.9 MB Publisher’s postprint open-access - 8.0580669 - ÚOCHB 2024 RIV jpn P - Patent Document
Šimková, Adéla - Šácha, Pavel - Sidej, Natan - Ormsby, Tereza - Konvalinka, Jan
線維芽細胞活性化タンパク質を阻害するための化合物.
[Compounds for inhibition of fibroblast activation protein.]
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 24.10.2023. Patent Number: JP7368637. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA ČR(CZ) GA19-10280S; GA MZd(CZ) NV15-31379A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2015064; GA MZd(CZ) NU22-03-00318; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : FAP * protease * inhibition
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/075953813/publication/JP7368637B2?q=JP7368637B2
Permanent Link: https://hdl.handle.net/11104/0349430File Download Size Commentary Version Access JP7368637B2.pdf 3 20.6 MB Publisher’s postprint open-access - 9.0580664 - ÚOCHB 2024 RIV eng P - Patent Document
Šimková, Adéla - Šácha, Pavel - Sidej, Natan - Ormsby, Tereza - Konvalinka, Jan
Compounds for inhibition of fibroblast activation protein.
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 27.09.2023. Patent Number: EP4126841. Territorial Protection: evropský patent podle Evropské patentové úmluvy ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA ČR(CZ) GA19-10280S; GA MZd(CZ) NV15-31379A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2015064; GA MZd(CZ) NU22-03-00318; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : FAP * protease * inhibition
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/075953813/publication/EP4126841B1?q=EP4126841B1
Permanent Link: https://hdl.handle.net/11104/0349428File Download Size Commentary Version Access EP4126841B1.pdf 3 8.5 MB Publisher’s postprint open-access - 10.0580493 - BC 2024 RIV CH eng J - Journal Article
Martins, Larissa Almeida - Buša, Michal - Chlastáková, A. - Kotál, Jan - Beránková, Z. - Stergiou, N. - Jmel, Mohamed Amine - Schmitt, E. - Chmelař, J. - Mareš, Michael - Kotsyfakis, Michalis
Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host.
Cellular and Molecular Life Sciences. Roč. 80, č. 11 (2023), č. článku 339. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LTAUSA19109
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : ray crystal-structure * sialostatin-l * functional expression * cysteine cathepsins * mammalian legumain * ixodes-scapularis * inhibitors * stefin * generation * peptidase * Ixodes ricinus * Tick saliva * Cystatins * Protease inhibition * Protein structure * Host-parasite interactions
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 8, year: 2022
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00018-023-04993-4
Permanent Link: https://hdl.handle.net/11104/0349268