Search results
- 1.0579804 - ÚMG 2024 RIV US eng J - Journal Article
Mejdrova, I. - Dušek, J. - Škach, K. - Štefela, A. - Škoda, J. - Chalupský, Karel - Dohnalová, Klára - Pávková, I. - Kronenberger, T. - Rashidian, A. - Smutná, L. - Duchoslav, V. - Smutný, T. - Pávek, P. - Nencka, R.
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
Journal of Medicinal Chemistry. Roč. 66, č. 4 (2023), s. 2422-2456. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LM2015040; GA ČR GA22-05167S; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:68378050
Keywords : pregnane-x-receptor * car * activation * pxr * ligand * derivatives * identification * artemisinin * metabolites * expression
OECD category: Cell biology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01140
Permanent Link: https://hdl.handle.net/11104/0348603 - 2.0576968 - BFÚ 2024 RIV GB eng J - Journal Article
Vazquez-Gomez, Gerardo - Petráš, Jiří - Dvořák, Z. - Vondráček, Jan
Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis.
Biochemical Pharmacology. Roč. 216, OCT 2023 (2023), č. článku 115797. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA22-00355S
Institutional support: RVO:68081707
Keywords : Colon cancer * Aryl hydrocarbon receptor * Pregnane X receptor * Intestine * Microbial agonists * Inflammation * Epithelial barrier * Dietary contaminants
OECD category: Pharmacology and pharmacy
Impact factor: 5.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S000629522300388X?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0350474 - 3.0569356 - ÚOCHB 2024 RIV US eng J - Journal Article
Mejdrová, Ivana - Dušek, J. - Škach, Kryštof - Štefela, A. - Škoda, J. - Chalupský, Karel - Dohnalová, K. - Pavková, I. - Kronenberger, T. - Rashidian, A. - Smutná, L. - Duchoslav, Vojtěch - Smutný, T. - Pávek, P. - Nencka, Radim
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
Journal of Medicinal Chemistry. Roč. 66, č. 4 (2023), s. 2422-2456. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : pregnane X receptor * CAR * activation
OECD category: Pharmacology and pharmacy
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c01140
Permanent Link: https://hdl.handle.net/11104/0340675
Research data: Zenodo - 4.0556112 - BFÚ 2023 RIV NL eng J - Journal Article
Šimečková, P. - Pěnčíková, K. - Kováč, O. - Slavík, J. - Parenicova, M. - Vondráček, Jan - Machala, M.
In vitro profiling of toxic effects of environmental polycyclic aromatic hydrocarbons on nuclear receptor signaling, disruption of endogenous metabolism and induction of cellular stress.
Science of the Total Environment. Roč. 815, APR 1 2022 (2022), č. článku 151967. ISSN 0048-9697. E-ISSN 1879-1026
R&D Projects: GA ČR(CZ) GA21-00533S
Institutional support: RVO:68081707
Keywords : pregnane-x-receptor * primary human hepatocytes * aryl-hydrocarbon * estrogen-receptor * mediated activity * hepg2 cells * cross-talk * activation
OECD category: Ecology
Impact factor: 9.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0048969721070431?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0339759 - 5.0477884 - ÚI 2018 CZ eng J - Journal Article
Smutný, T. - Duintjer Tebbens, Jurjen - Pávek, P.
Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 "missing heritability'' enigma.
Journal of Applied Biomedicine. Roč. 13, č. 3 (2015), s. 181-188. ISSN 1214-021X. E-ISSN 1214-0287
Keywords : pregnane x receptor * microrna binding-sites * vitamin-d-receptor * transcriptional regulation * human liver * cytochrome-p450 3a4 * human hepatocytes * factor 4-alpha * in-silico * identification * miRNA * Gene regulation * cyp3a4 * Cytochrome P450 * Metabolism
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 1.509, year: 2015
Permanent Link: http://hdl.handle.net/11104/0274103