Search results
- 1.0583244 - FGÚ 2025 RIV CH eng J - Journal Article
Kysilov, Bohdan - Kuchtiak, Viktor - Hrčka Krausová, Barbora - Balík, Aleš - Kořínek, Miloslav - Fili, Klevinda - Dobrovolski, Mark - Abramová, Vera - Chodounská, Hana - Kudová, Eva - Božíková, Paulina - Černý, Jiří - Smejkalová, Tereza - Vyklický ml., Ladislav
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids.
Cellular and Molecular Life Sciences. Roč. 81, č. 1 (2024), č. článku 36. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR(CZ) GA23-04922S; GA TA ČR(CZ) TN02000109; GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:67985823 ; RVO:61388963 ; RVO:86652036
Keywords : glutamate receptors * channelopathy * endogenous neuroactive steroid * GRIN2 genes * surface expression * rescue pharmacology
OECD category: Neurosciences (including psychophysiology
Impact factor: 8, year: 2022
Method of publishing: Open access
https://doi.org/10.1007/s00018-023-05062-6
Permanent Link: https://hdl.handle.net/11104/0351253 - 2.0534367 - FGÚ 2021 RIV NL eng J - Journal Article
Chvojková, Markéta - Rambousek, Lukáš - Chodounská, Hana - Kudová, Eva - Valeš, Karel
Synthetic structural modifications of neurosteroid pregnanolone sulfate: Assessment of neuroprotective effects in vivo.
European Journal of Pharmacology. Roč. 881, Aug 15 (2020), č. článku 173187. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GA18-09296S; GA ČR(CZ) GA14-20613S; GA MZd(CZ) NU20-04-00389
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : NMDA receptor * neuroactive steroid * behavior * neuroprotection * excitotoxicity * cognitive functions
OECD category: Neurosciences (including psychophysiology; Organic chemistry (UOCHB-X)
Impact factor: 4.432, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.ejphar.2020.173187
Permanent Link: http://hdl.handle.net/11104/0312575 - 3.0429104 - FGÚ 2015 RIV CH eng J - Journal Article
Holubová, Kristína - Nekovářová, Tereza - Pistovčáková, J. - Šulcová, A. - Stuchlík, Aleš - Valeš, Karel
Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exerts antidepressant-like properties in animal models.
Frontiers in Behavioral Neuroscience. Roč. 8, Apr 16 (2014), s. 130. ISSN 1662-5153
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GAP303/12/1464; GA MZd(CZ) NT13403; GA TA ČR(CZ) TE01020028
Grant - others:GA MŠk(CZ) LM2011017; GA MŠk(CZ) ED1.1.00/02.0068
Program: ED
Institutional support: RVO:67985823
Keywords : depression * anxiety * NMDA channel blocker * neuroactive steroid * 3a5b-pregnanolone glutamate
Subject RIV: FH - Neurology
Impact factor: 3.270, year: 2014
Permanent Link: http://hdl.handle.net/11104/0234290 - 4.0364480 - FGÚ 2012 RIV NL eng J - Journal Article
Rambousek, Lukáš - Bubeníková-Valešová, V. - Kačer, P. - Syslová, K. - Kenney, Jana - Holubová, Kristína - Najmanová, V. - Zach, P. - Svoboda, Jan - Stuchlík, Aleš - Chodounská, Hana - Kapras, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Vyklický ml., Ladislav - Valeš, Karel
Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate.
Neuropharmacology. Roč. 61, 1-2 (2011), s. 61-68. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA MZd(CZ) NS10365; GA MZd(CZ) NR9180; GA ČR(CZ) GA309/07/0271; GA ČR(CZ) GA203/08/1498; GA ČR(CZ) GA309/09/0286; GA MŠMT(CZ) 1M0517; GA MŠMT(CZ) LC554
Grant - others:EC(XE) LSMH-CT-2007-037765
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z40550506
Keywords : neuroactive steroid * NMDA * neuroprotectivity
Subject RIV: FH - Neurology
Impact factor: 4.814, year: 2011
Permanent Link: http://hdl.handle.net/11104/0199958 - 5.0041041 - FGÚ 2007 RIV CZ eng J - Journal Article
Mareš, Pavel - Haugvicová, Renata - Kasal, Alexander
Action of two neuroactive steroids against motor seizures induced by pentetrazol in rats during ontogeny.
[Účinek dvou neuroaktivních steroidů na křeče vyvolané pentetrazolem u potkanů v průběhu ontogeneze.]
Physiological Research. Roč. 55, č. 4 (2006), s. 437-444. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA AV ČR(CZ) IBS5011007
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z40550506
Keywords : neuroactive steroid * anticonvulsant action * development
Subject RIV: ED - Physiology
Impact factor: 2.093, year: 2006
Permanent Link: http://hdl.handle.net/11104/0134633