Search results
- 1.0489202 - FGÚ 2019 RIV GB eng J - Journal Article
Boulos, J. F. - Jakubík, Jan - Boulos, J. M. - Randáková, Alena - Momirov, J.
Synthesis of novel and functionally selective non‐competitive muscarinic antagonists as chemical probes.
Chemical Biology & Drug Design. Roč. 91, č. 1 (2018), s. 93-104. ISSN 1747-0277. E-ISSN 1747-0285
R&D Projects: GA ČR(CZ) GA14-05696S; GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:67985823
Keywords : G-protein-coupled receptor * muscarinic acetylcholine receptor * N-methylscopolamine * Parkinson's disease * positive allosteric modulator
OECD category: Physiology (including cytology)
Impact factor: 2.256, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283661 - 2.0398286 - FGÚ 2014 RIV NL eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Doležal, Vladimír
On homology modeling of the M-2 muscarinic acetylcholine receptor subtype.
Journal of Computer-Aided Molecular Design. Roč. 27, č. 6 (2013), s. 525-538. ISSN 0920-654X. E-ISSN 1573-4951
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GBP304/12/G069
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptor * G-protein coupled receptor * homology energy estimation * MM-GBSA
Subject RIV: ED - Physiology
Impact factor: 2.782, year: 2013
Permanent Link: http://hdl.handle.net/11104/0225814 - 3.0371077 - FGÚ 2012 RIV SK eng M - Monography Chapter
Jakubík, Jan - Doležal, Vladimír - El-Fakahany, E. E. - Janíčková, Helena - Randáková, Alena - Šantrůčková, Eva
Perspectives for design of selective muscarinic agonists.
New frontiers in molecular mechanisms in neurological and psychiatric disorders. Vol. 1. Martin: Jessenius Faculty of Medicine, 2011 - (Babušiková, E.; Dobrota, D.; Lehotský, J.), s. 154-168. ISBN 978-80-88866-99-2
R&D Projects: GA ČR(CZ) GA305/09/0681; GA AV ČR(CZ) IAA500110703; GA MŠMT(CZ) LC554
Institutional research plan: CEZ:AV0Z50110509
Keywords : muscarinic acetylcholine receptor agonists * Alzheimer's disease * schizophrenia
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0204705 - 4.0355377 - FGÚ 2011 RIV US eng J - Journal Article
Grant, M.K.O. - Noetzel, M.J. - De Lorme, K.C. - Jakubík, Jan - Doležal, Vladimír - El-Fakahany, E. E.
Pharmacological Evaluation of the Long-Term Effects of Xanomeline on the M1 Muscarinic Acetylcholine Receptor.
PLoS ONE. Roč. 5, č. 12 (2010), e15722-16. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR GA305/09/0681
Institutional research plan: CEZ:AV0Z50110509
Keywords : Xanomeline * muscarinic acetylcholine receptor
Subject RIV: CE - Biochemistry
Impact factor: 4.411, year: 2010
Permanent Link: http://hdl.handle.net/11104/0194161 - 5.0142293 - FGU-C 20020014 RIV US eng J - Journal Article
Jakubík, Jan - Tuček, Stanislav - El-Fakahany, E. E.
Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor.
Journal of Pharmacology and Experimental Therapeutics. Roč. 301, č. 3 (2002), s. 1033-1041. ISSN 0022-3565. E-ISSN 1521-0103
R&D Projects: GA ČR GP305/01/D119
Grant - others:NIH(US) NS25743
Institutional research plan: CEZ:AV0Z5011922
Keywords : xanomeline * M(1) muscarinic acetylcholine receptor
Subject RIV: FH - Neurology
Impact factor: 3.991, year: 2002
Permanent Link: http://hdl.handle.net/11104/0039999