Search results
- 1.0573369 - ÚOCHB 2024 RIV US eng J - Journal Article
Vaňková, Karolína - Keough, D. T. - Hocková, Dana - Guddat, L. W. - Janeba, Zlatko
N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
ChemMedChem. Roč. 18, č. 15 (2023), č. článku e202300211. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * inhibitors * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * malaria * Plasmodium falciparum
OECD category: Organic chemistry
Impact factor: 3.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/cmdc.202300211
Permanent Link: https://hdl.handle.net/11104/0343833 - 2.0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link: http://hdl.handle.net/11104/0319509 - 3.0510479 - ÚOCHB 2020 RIV FR eng J - Journal Article
Klejch, Tomáš - Keough, D. T. - Chavchich, M. - Travis, J. - Skácel, Jan - Pohl, Radek - Janeba, Zlatko - Edstein, M. D. - Avery, V. M. - Guddat, L. W. - Hocková, Dana
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
European Journal of Medicinal Chemistry. Roč. 183, Dec 1 (2019), č. článku 111667. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : hypoxanthine-guanine-xanthine phosphoribosyltransferase * sulfur-containing drugs * sulfide oxidation * Plasmodium falciparum * acyclic nucleoside phosphonates
OECD category: Organic chemistry
Impact factor: 5.573, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0223523419308116?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0300951 - 4.0495494 - ÚOCHB 2019 RIV GB eng J - Journal Article
Klejch, Tomáš - Pohl, Radek - Janeba, Zlatko - Sun, M. - Keough, D. T. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases.
Tetrahedron. Roč. 74, č. 40 (2018), s. 5886-5897. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : hypoxanthine-guanine-xanthine phosphoribosyltransferase * regioselective Mitsunobu reaction * acyclic nucleotide analogues * enzyme inhibition
OECD category: Organic chemistry
Impact factor: 2.379, year: 2018
Permanent Link: http://hdl.handle.net/11104/0288465 - 5.0474802 - ÚOCHB 2018 RIV GB eng J - Journal Article
Lukáč, Miloš - Hocková, Dana - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko
Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases.
Tetrahedron. Roč. 73, č. 6 (2017), s. 692-702. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * 6-oxopurine * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * copper(I)-catalyzed azide-alkyne cycloaddition
OECD category: Organic chemistry
Impact factor: 2.377, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271755 - 6.0376074 - ÚOCHB 2013 RIV GB eng J - Journal Article
Krečmerová, Marcela - Dračínský, Martin - Hocková, Dana - Holý, Antonín - Keough, D. T. - Guddat, L. W.
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogues as potential antimalarial agents.
Bioorganic & Medicinal Chemistry. Roč. 20, č. 3 (2012), s. 1222-1230. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1M0508; GA ČR GAP207/11/0108
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * Malaria * Plasmodium falciparum * Plasmodium vivax * hypoxanthine-guanine-(xanthine)-phosphoribosyltransferase
Subject RIV: CC - Organic Chemistry
Impact factor: 2.903, year: 2012
Permanent Link: http://hdl.handle.net/11104/0208573 - 7.0362830 - ÚOCHB 2012 GR eng A - Abstract
Pomeisl, Karel - Holý, Antonín - Krečmerová, Marcela
Syntheses of alpha-branched alkyl and aryl N-9-[2-(phoshonomethoxy)ethyl]-purines.
ESOC 2011. 17th European Symposium on Organic Chemistry. Crete: University of Crete, 2011. P1.163-P1.163.
[ESOC 2011. European Symposium on Organic Chemistry /17./. 10.07.2011-15.07.2011, Crete]
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : malaria * acyclic nucleoside phosphonates * dioxolanes * Mitsunobu reaction * hypoxanthine-guanine-xanthine phosphoribosyltransferase
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0199027