Search results
- 1.0586002 - ÚOCHB 2025 RIV US eng J - Journal Article
Spiwoková, Petra - Horn, Martin - Fanfrlík, Jindřich - Jílková, Adéla - Fajtová, Pavla - Leontovyč, Adrian - Houštecká, Radka - Bieliková, Lucia - Brynda, Jiří - Chanová, M. - Mertlíková-Kaiserová, Helena - Diaz-Caro, E. J. E. - Almaliti, J. - El Sakkary, N. - Gerwick, W. H. - Caffrey, C. R. - Mareš, Michael
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
ACS Infectious Diseases. Roč. 10, č. 6 (2024), s. 1935-1948. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LUAUS23050; GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine protease * drug target * parasite * Schistosoma mansoni * acrylamide inhibitor
Impact factor: 5.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.3c00589
Permanent Link: https://hdl.handle.net/11104/0353623 - 2.0569875 - ÚOCHB 2024 RIV AU eng J - Journal Article
Peterková, K. - Vorel, J. - Ilgová, J. - Ostašov, P. - Fajtová, Pavla - Konečný, L. - Chanová, M. - Kašný, M. - Horn, Martin - Dvořák, Jan
Proteases and their inhibitors involved in Schistosoma mansoni egg-host interaction revealed by comparative transcriptomics with Fasciola hepatica eggs.
International Journal for Parasitology. Roč. 53, 5/6 (2023), s. 253-263. ISSN 0020-7519. E-ISSN 1879-0135
R&D Projects: GA MŠMT(CZ) LM2018131; GA ČR(CZ) GA19-17269S; GA MZd(CZ) NV18-05-00345
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : Schistosoma mansoni * egg * Fasciola hepatica * comparative transcriptomics * protease * protease inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ijpara.2022.12.007
Permanent Link: https://hdl.handle.net/11104/0341213
Research data: NCBI BioProject - 3.0566024 - ÚOCHB 2023 RIV GB eng J - Journal Article
Jedličková, L. - Peterková, K. - Boateng, E. M. - Ulrychová, Lenka - Vacek, V. - Kutil, Zsofia - Jiang, Z. - Nováková, Zora - Šnajdr, Ivan - Kim, J. - O’Donoghue, A. J. - Bařinka, Cyril - Dvořák, Jan
Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.
Parasites & Vectors. Roč. 15, č. 1 (2022), č. článku 480. ISSN 1756-3305. E-ISSN 1756-3305
R&D Projects: GA ČR(CZ) GA18-14167S; GA ČR(CZ) GJ19-22269Y
Institutional support: RVO:61388963 ; RVO:86652036
Keywords : platyhelminth * M28B metalloproteases * prostate specific-membrane antigen * Schistosoma mansoni * Fasciola hepatica * RNA in situ hybridization * folate hydrolase * immunohistochemistry * NAALADase
OECD category: Biochemistry and molecular biology
Impact factor: 3.2, year: 2022
Method of publishing: Open access
https://doi.org/10.1186/s13071-022-05556-5
Permanent Link: https://hdl.handle.net/11104/0337467 - 4.0555512 - BC 2023 RIV DE eng J - Journal Article
Yoneva, Aneta - van Beest, Gabrielle Shira - Born-Torrijos, Ana
Search, find, and penetrate: ultrastructural data of furcocercariae of Cardiocephaloides longicollis (Digenea, Strigeidae) explain their transmission and infection strategy into fish hosts.
Parasitology Research. Roč. 121, č. 3 (2022), s. 877-889. ISSN 0932-0113. E-ISSN 1432-1955
R&D Projects: GA ČR(CZ) GJ20-14903Y
Institutional support: RVO:60077344
Keywords : diplostomum pseudospathaceum niewiadomska * 1984 cercariae digenea * schistosoma-mansoni * sensory receptors * surface ultrastructure * parasite transmission * electron-microscopy * alimentary-tract * phoxini faust * life-cycle * Transmission strategy * Trematode parasite * Free-swimming larvae * tem
OECD category: Behavioral sciences biology
Impact factor: 2, year: 2022
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00436-022-07448-0
Permanent Link: https://hdl.handle.net/11104/0340547 - 5.0543094 - ÚOCHB 2022 RIV GB eng J - Journal Article
Ulrychová, Lenka - Ostašov, P. - Chanová, M. - Mareš, Michael - Horn, Martin - Dvořák, J.
Spatial expression pattern of serine proteases in the blood fluke Schistosoma mansoni determined by fluorescence RNA in situ hybridization.
Parasites & Vectors. Roč. 14, č. 1 (2021), č. článku 274. ISSN 1756-3305. E-ISSN 1756-3305
R&D Projects: GA MZd(CZ) NV18-05-00345; GA ČR(CZ) GA19-17269S; GA MŠMT(CZ) 8J19AT036
Institutional support: RVO:61388963
Keywords : blood fluke * fluorescence RNA in situ hybridization * mRNA detection * platyhelminthes * Schistosoma mansoni * serine proteases * transcript
OECD category: Biochemistry and molecular biology
Impact factor: 4.052, year: 2021
Method of publishing: Open access
https://doi.org/10.1186/s13071-021-04773-8
Permanent Link: http://hdl.handle.net/11104/0320382 - 6.0540888 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Rubešová, Petra - Fanfrlík, Jindřich - Fajtová, Pavla - Řezáčová, Pavlína - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Emal, C. D. - Renslo, A. R. - Roush, W. R. - Horn, Martin - Caffrey, C. R. - Mareš, Michael
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
ACS Infectious Diseases. Roč. 7, č. 5 (2021), s. 1077-1088. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LH15040; GA MŠMT LO1302; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine peptidase * drug target * parasite * Schistosoma mansoni * vinyl sulfone inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00501
Permanent Link: http://hdl.handle.net/11104/0318491 - 7.0537297 - BC 2021 RIV GB eng J - Journal Article
Corrigan, T.S. - Diaz, L.M.L. - Border, S.E. - Ratigan, S.C. - Kasper, K.Q. - Sojka, Daniel - Fajtova, P. - Caffrey, C.R. - Salvesen, G. S. - McElroy, C.A. - Hadad, C.M. - Ekici, O.D.
Design, synthesis, andin vitroevaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1387-1402. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : asparaginyl endopeptidase * schistosoma-mansoni * michael acceptors * caspase family * key mediators * legumain * expression * potent * generation * epoxides * Proteasome inhibitor * caspase and legumain inhibitors * aza-peptide carbonyls * anticancer * antiparasitic
OECD category: Microbiology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/pdf/10.1080/14756366.2020.1781107?needAcces
Permanent Link: http://hdl.handle.net/11104/0315029 - 8.0525103 - ÚOCHB 2021 RIV US eng M - Monography Chapter
Jílková, Adéla - Horn, Martin - Mareš, Michael
Structural and Functional Characterization of Schistosoma mansoni Cathepsin B1.
Schistosoma mansoni: Methods and Protocols. New York: Humana Press, 2020 - (Timson, D.), s. 145-158. Methods in Molecular Biology, 2151. ISBN 978-1-0716-0634-6
R&D Projects: GA MZd(CZ) NV18-05-00345; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : parasite * Schistosoma mansoni * protease * cathepsin B * expression * activity assay * inhibition * crystal structure
OECD category: Biochemistry and molecular biology
Permanent Link: http://hdl.handle.net/11104/0309316 - 9.0525102 - ÚOCHB 2021 RIV US eng M - Monography Chapter
Leontovyč, Adrian - Ulrychová, Lenka - Horn, Martin - Dvořák, Jan
Collection of Excretory/Secretory Products from Individual Developmental Stages of the Blood Fluke Schistosoma mansoni.
Schistosoma mansoni: Methods and Protocols. New York: Humana Press, 2020 - (Timson, D.), s. 55-63. Methods in Molecular Biology, 2151. ISBN 978-1-0716-0634-6
R&D Projects: GA ČR(CZ) GA19-17269S
Institutional support: RVO:61388963
Keywords : Schistosoma mansoni * developmental stages * excretory/secretory products
OECD category: Biochemistry and molecular biology
Permanent Link: http://hdl.handle.net/11104/0309314 - 10.0525099 - ÚOCHB 2021 RIV US eng M - Monography Chapter
Ulrychová, Lenka - Horn, Martin - Dvořák, Jan
Sensitive Fluorescence In Situ Hybridization on Semithin Sections of Adult Schistosoma mansoni Using DIG-Labeled RNA Probes.
Schistosoma mansoni: Methods and Protocols. New York: Humana Press, 2020 - (Timson, D.), s. 43-53. Methods in Molecular Biology, 2151. ISBN 978-1-0716-0634-6
R&D Projects: GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : Schistosoma mansoni * adult worm * tissue section * in situ hybridization * RNA probe * digoxigenin labeling * fluorescence RNA detection
OECD category: Biochemistry and molecular biology
Permanent Link: http://hdl.handle.net/11104/0309312