Search results
- 1.0579081 - ÚMG 2024 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Peřina, M. - Vojáčková, V. - Pospíšil, T. - Djukic, S. - Škerlová, Jana - Grúz, J. - Renešová, N. - Klener, P. - Řezáčová, P. - Strnad, M. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-id/i]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry. Roč. 65, č. 13 (2022), s. 8881-8896. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : roscovitine * expression * cell line
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02184
Permanent Link: https://hdl.handle.net/11104/0347953 - 2.0541528 - ÚMG 2021 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Šturc, A. - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, M. - Peřina, M. - Pospíšil, T. - Šiiroká, J. - Urbánek, L. - Pachl, P. - Řezáčová, Pavlína - Strnad, M. - Klener, P. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : biological evaluation * cell-cycle * roscovitine * potent * apoptosis * subgroups * purines * abt-199
OECD category: Biochemistry and molecular biology
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0319083 - 3.0541026 - ÚEB 2022 RIV CZ eng J - Journal Article
Spicakova, A. - Kraus, Petr - Gucký, Tomáš - Kryštof, Vladimír - Strnad, Miroslav - Bazgier, V. - Otyepka, M. - Kubickova, V. - Poruba, M. - Rácová, Z. - Zapletalová, I. - Anzenbacher, P.
in vitro and in silico Studies of Interaction of Synthetic 2,6,9-Trisubstituted Purine Kinase Inhibitors BPA-302, BP-21 and BP-117 With Liver Drug-Metabolizing Cytochromes P450.
Physiological Research. Roč. 69, SEP (2020), s. 627-636. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MZd(CZ) NV17-28231A
Institutional support: RVO:61389030
Keywords : r-roscovitine * cell-cycle * cancer * series * Cytochrome P450 inhibition * High performance liquid chromatography * Cyclin-dependent kinase inhibitor * FLT3-ITD inhibitor * Drug metabolism
OECD category: Organic chemistry
Impact factor: 1.881, year: 2020
Method of publishing: Open access
https://www.biomed.cas.cz/physiolres/pdf/2020/69_S627.pdf
Permanent Link: http://hdl.handle.net/11104/0318600File Download Size Commentary Version Access 2020_Spicakova_Physiological Research_S627.pdf 1 2.5 MB Other open-access - 4.0505109 - ÚEB 2020 RIV US eng J - Journal Article
Jorda, Radek - Havlíček, Libor - Šturc, Antonín - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, Michaela - Peřina, Miroslav - Pospíšil, Tomáš - Široká, Jitka - Urbánek, Lubor - Pachl, Petr - Řezáčová, Pavlína - Strnad, Miroslav - Klener, P. - Kryštof, Vladimír
3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA17-14007S; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : BIOLOGICAL EVALUATION * CELL-CYCLE * ROSCOVITINE
OECD category: Hematology; Medicinal chemistry (UOCHB-X)
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
http://doi.org/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0296627File Download Size Commentary Version Access 2019_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_4606.pdf 4 4.5 MB Other require - 5.0504503 - BFÚ 2020 RIV AT eng J - Journal Article
Orság, Petr - Havran, Luděk - Fojt, Lukáš - Coufal, Jan - Brázda, Václav - Fojta, Miroslav
Voltammetric behavior of a candidate anticancer drug roscovitine at carbon electrodes in aqueous buffers and a cell culture medium.
Monatshefte fur Chemie. Roč. 150, č. 3 (2019), s. 461-467. ISSN 0026-9247. E-ISSN 1434-4475
R&D Projects: GA ČR GBP206/12/G151
Institutional support: RVO:68081707
Keywords : cyclin-dependent kinases * r-roscovitine * in-vitro
OECD category: Analytical chemistry
Impact factor: 1.349, year: 2019
Method of publishing: Limited access
https://link.springer.com/article/10.1007%2Fs00706-018-2333-5
Permanent Link: http://hdl.handle.net/11104/0296122 - 6.0492257 - ÚEB 2019 RIV US eng J - Journal Article
Cherukupalli, S. - Chandrasekaran, B. - Kryštof, Vladimír - Aleti, R.R. - Sayyad, N. - Merugu, S.R. - Kushwaha, N.D. - Karpoormath, R.
Synthesis, anticancer evaluation, and molecular docking studies of some novel 4,6-disubstituted pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 (CDK2) inhibitors.
Bioorganic Chemistry. Roč. 79, SEP (2018), s. 46-59. ISSN 0045-2068. E-ISSN 1090-2120
R&D Projects: GA MŠMT(CZ) LO1204; GA ČR GA17-14007S
Institutional support: RVO:61389030
Keywords : cancer-therapy * cell-cycle * cyclin-dependent-kinase-2 * roscovitine * lethality * scaffold * targets * mice * Pyrazolo[3,4-d]pyrimidine * Cyclin dependent kinase inhibitor * Anti-proliferative activity * Molecular docking * glide
OECD category: Oncology
Impact factor: 3.926, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285792File Download Size Commentary Version Access 2018_Cherukupalli_BIOORGANIC CHEMISTRY_46.pdf 2 1.1 MB Other open-access - 7.0491930 - ÚEB 2019 RIV NL eng J - Journal Article
Široká, Jitka - Čečková, M. - Urbánek, Lubor - Kryštof, Vladimír - Gucký, Tomáš - Hofman, J. - Strnad, Miroslav - Štaud, F.
LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. Roč. 1089, JUL 1 (2018), s. 24-32. ISSN 1570-0232. E-ISSN 1873-376X
R&D Projects: GA ČR GA17-14007S
Institutional support: RVO:61389030
Keywords : seliciclib r-roscovitine * hepatocellular-carcinoma * metabolism * potent * cdc2 * Cyclin-dependent kinase inhibitor * bp-14 * bp-20 * Pharmacokinetics * Tissue distribution
OECD category: Analytical chemistry
Impact factor: 2.813, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285531File Download Size Commentary Version Access 2018_Siroka_JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES_24.pdf 3 995.1 KB Other open-access - 8.0446805 - ÚEB 2016 RIV US eng J - Journal Article
Havlíček, Libor - Moravcová, Daniela - Kryštof, Vladimír - Strnad, Miroslav
The Identification of a Novel Highly Condensed Pentacyclic Heteroaromatic Ring System 1,3,5,5b,6,8,10,10b-Octaazacyclopenta[h,i]Aceanthrylene and its Application in the Synthesis of 5,7-Substituted Pyrazolo[4,3-d]Pyrimidines.
Journal of Heterocyclic Chemistry. Roč. 52, č. 3 (2015), s. 669-673. ISSN 0022-152X. E-ISSN 1943-5193
R&D Projects: GA ČR GAP305/12/0783
Institutional support: RVO:61389030
Keywords : roscovitine * pyrazolo[4,3-d]pyrimidine * kinase inhibitor
Subject RIV: CE - Biochemistry
Impact factor: 0.685, year: 2015
Permanent Link: http://hdl.handle.net/11104/0248761File Download Size Commentary Version Access 2015_Havlicek_JOURNAL OF HETEROCYCLIC CHEMISTRY_669.pdf 2 307.5 KB Author’s postprint open-access - 9.0421049 - ÚEB 2014 RIV US eng J - Journal Article
Haider, C. - Grubinger, M. - Řezníčková, Eva - Weiss, T.S. - Rotheneder, H. - Miklos, W. - Berger, W. - Jorda, Radek - Zatloukal, M. - Gucký, T. - Strnad, Miroslav - Kryštof, Vladimír - Mikulits, W.
Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance.
Molecular Cancer Therapeutics. Roč. 12, č. 10 (2013), s. 1947-1957. ISSN 1535-7163. E-ISSN 1538-8514
R&D Projects: GA ČR GAP305/12/0783; GA ČR GA301/08/1649
Institutional research plan: CEZ:AV0Z50380511
Keywords : PRIMARY HUMAN HEPATOCYTES * SELICICLIB R-ROSCOVITINE * CELL-CYCLE
Subject RIV: CE - Biochemistry
Impact factor: 6.107, year: 2013
Permanent Link: http://hdl.handle.net/11104/0227508File Download Size Commentary Version Access 2013_Haider_MOLECULAR CANCER THERAPEUTICS_1947-1957.pdf 11 1.6 MB Other open-access - 10.0398210 - ÚMG 2014 RIV GB eng J - Journal Article
Molinsky, J. - Klánová, M. - Koc, Michal - Beranová, Lenka - Anděra, Ladislav - Ludvíková, Z. - Bohmova, M. - Gasova, Z. - Strnad, Miroslav - Ivánek, R. - Trněný, M. - Nečas, E. - Živný, J. - Klener, P.
Roscovitine sensitizes leukemia and lymphoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Leukemia & Lymphoma. Roč. 54, č. 2 (2013), s. 372-380. ISSN 1042-8194. E-ISSN 1029-2403
R&D Projects: GA MZd NS10287
Institutional research plan: CEZ:AV0Z50380511
Institutional support: RVO:68378050
Keywords : roscovitine * TRAIL * synergism * apoptosis * leukemia * lymphoma
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.605, year: 2013
Permanent Link: http://hdl.handle.net/11104/0228407File Download Size Commentary Version Access 2013_Molinsky_LEUKEMIA & LYMPHOMA_372.pdf 0 2.1 MB Other open-access