Search results
- 1.0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link: http://hdl.handle.net/11104/0319509 - 2.0489497 - ÚOCHB 2019 RIV US eng J - Journal Article
Keough, D. T. - Rejman, Dominik - Pohl, Radek - Zborníková, Eva - Hocková, Dana - Croll, T. - Edstein, M. D. - Birrell, G. W. - Chavchich, M. - Naesens, L. M. J. - Pierens, G. K. - Brereton, I. M. - Guddat, L. W.
Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chemical Biology. Roč. 13, č. 1 (2018), s. 82-90. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR(CZ) GA16-06049S; GA ČR GA15-11711S
Institutional support: RVO:61388963
Keywords : plasmodium vivax * inhibitor * pyrrolidine nucleotide bisphosphonate * HXGPRT
OECD category: Organic chemistry
Impact factor: 4.374, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283906 - 3.0376074 - ÚOCHB 2013 RIV GB eng J - Journal Article
Krečmerová, Marcela - Dračínský, Martin - Hocková, Dana - Holý, Antonín - Keough, D. T. - Guddat, L. W.
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogues as potential antimalarial agents.
Bioorganic & Medicinal Chemistry. Roč. 20, č. 3 (2012), s. 1222-1230. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1M0508; GA ČR GAP207/11/0108
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * Malaria * Plasmodium falciparum * Plasmodium vivax * hypoxanthine-guanine-(xanthine)-phosphoribosyltransferase
Subject RIV: CC - Organic Chemistry
Impact factor: 2.903, year: 2012
Permanent Link: http://hdl.handle.net/11104/0208573 - 4.0345886 - ÚOCHB 2011 RIV NL eng J - Journal Article
Keough, D. T. - Hocková, Dana - Krečmerová, Marcela - Česnek, Michal - Holý, Antonín - Naesens, L. - Brereton, I. M. - Winzor, D. J. - de Jersey, J. - Guddat, L. W.
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy.
Molecular and Biochemical Parasitology. Roč. 173, č. 2 (2010), s. 165-169. ISSN 0166-6851. E-ISSN 1872-9428
R&D Projects: GA MŠMT 1M0508
Grant - others:National Health and Medical Research Council(AU) 569703
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * Plasmodium vivax * 6-oxopurine phosphoribosyltransferase
Subject RIV: CC - Organic Chemistry
Impact factor: 2.875, year: 2010
Permanent Link: http://hdl.handle.net/11104/0187064