Search results
- 1.0573369 - ÚOCHB 2024 RIV US eng J - Journal Article
Vaňková, Karolína - Keough, D. T. - Hocková, Dana - Guddat, L. W. - Janeba, Zlatko
N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
ChemMedChem. Roč. 18, č. 15 (2023), č. článku e202300211. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * inhibitors * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * malaria * Plasmodium falciparum
OECD category: Organic chemistry
Impact factor: 3.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/cmdc.202300211
Permanent Link: https://hdl.handle.net/11104/0343833 - 2.0556761 - ÚOCHB 2023 RIV US eng J - Journal Article
Klejch, Tomáš - Keough, D. T. - King, G. - Doleželová, Eva - Česnek, Michal - Buděšínský, Miloš - Zíková, Alena - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
Journal of Medicinal Chemistry. Roč. 65, č. 5 (2022), s. 4030-4057. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA19-07707S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : hypoxanthine-guanine phosporibosyltransferase * Plasmodium falciparum * Helicobacter pylori
OECD category: Medicinal chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01881
Permanent Link: http://hdl.handle.net/11104/0330950 - 3.0555913 - BC 2023 RIV GB eng J - Journal Article
Kořený, L. - Oborník, Miroslav - Horáková, Eva - Waller, R. - Lukeš, Julius
The convoluted history of haem biosynthesis.
Biological Reviews. Roč. 97, č. 1 (2022), s. 141-162. ISSN 1464-7931. E-ISSN 1469-185X
R&D Projects: GA ČR(CZ) GA21-03224S; GA ČR(CZ) GA20-07186S; GA ČR(CZ) GA21-09283S; GA MŠMT(CZ) LL1601; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : protoporphyrinogen-ix-oxidase * nuclear gene-expression * tetrapyrrole biosynthesis * plasmodium-falciparum * ferrochelatase activity * transfer-rna * iron-sulfur * mitochondrial localization * coproporphyrinogen oxidase * subcellular-localization * tetrapyrrole * porphyrin * metabolic pathways * evolution * eukaryogenesis * mitochondrion * chloroplast * photosynthesis * iron metabolism
OECD category: Biochemistry and molecular biology
Impact factor: 10, year: 2022
Method of publishing: Open access
https://onlinelibrary.wiley.com/doi/10.1111/brv.12794
Permanent Link: https://hdl.handle.net/11104/0339399 - 4.0555034 - BC 2022 RIV CH eng J - Journal Article
Šnebergerová, Pavla - Bartošová-Sojková, Pavla - Jalovecká, M. - Sojka, Daniel
Plasmepsin-like Aspartyl Proteases in Babesia.
Pathogens. Roč. 10, č. 10 (2021), č. článku 1241. E-ISSN 2076-0817
R&D Projects: GA ČR(CZ) GA20-05736S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) LTAUSA17201
Institutional support: RVO:60077344
Keywords : falciparum food vacuole * plasmodium-falciparum * apicomplexan parasites * malaria parasite * cell invasion * glycophorin-a * protein * merozoite * microti * ultrastructure * aspartyl protease * plasmepsin * apicomplexa * piroplasmida * Babesia
OECD category: Immunology
Impact factor: 4.531, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2076-0817/10/10/1241
Permanent Link: http://hdl.handle.net/11104/0329650 - 5.0555025 - BC 2022 RIV CH eng J - Journal Article
Sojka, Daniel - Šnebergerová, Pavla - Robbertse, Luise
Protease Inhibition-An Established Strategy to Combat Infectious Diseases.
International Journal of Molecular Sciences. Roč. 22, č. 11 (2021), č. článku 5762. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA20-05736S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : plasmodium-falciparum * plasmepsin-v * malaria parasites * drug discovery * potent * validation * proteins * invasion * egress * target * protease * parasites * inhibition * therapy * infectious diseases
OECD category: Immunology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/11/5762
Permanent Link: http://hdl.handle.net/11104/0329643 - 6.0554920 - BC 2022 RIV CH eng J - Journal Article
Richtová, Jitka - Sheiner, L. - Gruber, Ansgar - Yang, Shun-Min - Kořený, L. - Striepen, B. - Oborník, Miroslav
Using Diatom and Apicomplexan Models to Study the Heme Pathway of Chromera velia.
International Journal of Molecular Sciences. Roč. 22, č. 12 (2021), č. článku 6495. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA21-03224S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : toxoplasma-gondii * protein import * tetrapyrrole biosynthesis * phaeodactylum-tricornutum * nuclear transformation * plasmodium-falciparum * targeting sequences * secondary plastids * ferrochelatase * trafficking * tetrapyrrole biosynthesis * heterologous expression * Chromera velia * predictions
OECD category: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://pubmed.ncbi.nlm.nih.gov/34204357/
Permanent Link: http://hdl.handle.net/11104/0329557 - 7.0550914 - BC 2022 RIV GB eng J - Journal Article
Doleželová, Eva - Klejch, Tomáš - Špaček, Petr - Slapničková, Martina - Guddat, L. - Hocková, Dana - Zíková, Alena
Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro.
Scientific Reports. Roč. 11, č. 1 (2021), č. článku 13317. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA19-07707S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : plasmodium-falciparum * 6-oxopurine phosphoribosyltransferases * antimalarial activity * crystal-structure * adenosine kinase * purine salvage * prodrugs * vivax * protein * bisphosphonates
OECD category: Microbiology; Organic chemistry (UOCHB-X)
Impact factor: 4.997, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41598-021-91747-6
Permanent Link: http://hdl.handle.net/11104/0326211 - 8.0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link: http://hdl.handle.net/11104/0319509 - 9.0541387 - BFÚ 2021 RIV US eng J - Journal Article
Gazanion, E. - Lacroix, L. - Alberti, P. - Gurung, P. - Wein, S. - Cheng, M. - Mergny, Jean-Louis - Gomes, A. R. - Lopez-Rubio, J.J.
Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites.
PLoS Genetics. Roč. 16, č. 7 (2020), č. článku e1008917. ISSN 1553-7404. E-ISSN 1553-7404
R&D Projects: GA MŠMT EF15_003/0000477
Institutional support: RVO:68081707
Keywords : mutually exclusive expression * plasmodium-falciparum * virulence genes * antigenic variation * small-molecule * dna
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 5.917, year: 2020
Method of publishing: Open access
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008917
Permanent Link: http://hdl.handle.net/11104/0318946 - 10.0538237 - BC 2021 RIV GB eng J - Journal Article
Horáková, Eva - Faktorová, Drahomíra - Kraeva, N. - Kaur, Binnypreet - Van den Abbeele, J. - Yurchenko, V. - Lukeš, Julius
Catalase compromises the development of the insect and mammalian stages of Trypanosoma brucei.
FEBS Journal. Roč. 287, č. 5 (2020), s. 964-977. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA MŠMT(CZ) LL1601; GA MŠMT(CZ) EF16_019/0000759
EU Projects: European Commission(BE) COST Action CA15133
Institutional support: RVO:60077344
Keywords : superoxide-dismutase * plasmodium-falciparum * metabolism * mitochondria * biogenesis * mechanisms * expression * diversity * evolution * pathogen * catalase * development * hydrogen peroxide * trypanosoma
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 5.542, year: 2020
Method of publishing: Limited access
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15083
Permanent Link: http://hdl.handle.net/11104/0316063