Search results
- 1.0578373 - ÚMG 2024 RIV GB eng J - Journal Article
Niederlová, Veronika - Tsyklauri, Oksana - Kovář, Marek - Štěpánek, Ondřej
IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy.
Trends in Immunology. Roč. 44, č. 11 (2023), s. 890-901. ISSN 1471-4906. E-ISSN 1471-4981
R&D Projects: GA ČR GA22-21356S; GA ČR(CZ) GA22-20548S; GA MŠMT(CZ) LX22NPO5103; GA MŠMT LX22NPO5102
EU Projects: European Commission(XE) 802878 - FunDiT
Research Infrastructure: e-INFRA CZ II - 90254
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : cancer * cytotoxic T cells * il-2 * immunotherapy * pd-1 * regulatory T cell
OECD category: Immunology; Immunology (MBU-M)
Impact factor: 16.8, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S1471490623001953?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0347367File Download Size Commentary Version Access Niederlova et al_Trends in Immunology.pdf 0 2 MB Publisher’s postprint open-access - 2.0569557 - ÚMG 2024 RIV GB eng J - Journal Article
Tsyklauri, Oksana - Chadimová, Tereza - Niederlová, Veronika - Kovářová, Jiřina - Michálik, Juraj - Malátová, Iva - Janušová, Šárka - Ivashchenko, Olha - Rossez, H. - Drobek, Aleš - Večeřová, Hana - Galati, V. - Kovář, Marek - Štěpánek, Ondřej
Regulatory T cells suppress the formation of potent KLRK1 and IL- 7R expressing effector CD8 T cells by limiting IL-2.
eLife. Roč. 12, Jan 27 (2023), č. článku e79342. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MŠMT LX22NPO5102; GA ČR GJ19-03435Y; GA ČR(CZ) GA22-20548S; GA ČR GA22-18046S; GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109
EU Projects: European Commission(XE) 802878 - FunDiT
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : IL-2 * T cells * autoimmunity * cytotoxic * immune suppression * immunology * inflammation * mouse * regulatory T cells
OECD category: Immunology; Immunology (MBU-M)
Impact factor: 7.7, year: 2022
Method of publishing: Open access
https://elifesciences.org/articles/79342
Permanent Link: https://hdl.handle.net/11104/0340929File Download Size Commentary Version Access elife-Tsyklauri O.-2023.pdf 0 3.4 MB Publisher’s postprint open-access - 3.0556089 - ÚMG 2022 RIV CN eng J - Journal Article
Vacaresse, N. - Ferzoco, A. - Filipp, Dominik - Amemiya, Y. - Seth, A. - Andrews, D. - Kinoshita, T. - Julius, M.
The Glycosylphosphatidylinositol Anchor Regulates T Cell Antigen Receptor Induced IL-2 Production.
Open Journal of Immunology. Roč. 13, March (2021), č. článku 2076. ISSN 2162-450X. E-ISSN 2162-4526
Institutional support: RVO:68378050
Keywords : GPI Anchor * TCR Regulation * IL-2 Production
OECD category: Immunology
Method of publishing: Limited access
https://www.scirp.org/journal/oji/
Permanent Link: http://hdl.handle.net/11104/0330469 - 4.0550778 - MBÚ 2022 RIV GB eng J - Journal Article
Tomala, Jakub - Weberová, Petra - Tomalová, Barbora - Zákostelská, Zuzana - Sivák, Ladislav - Kovářová, Jiřina - Kovář, Marek
IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-gamma production by CD25(+)Foxp3(-) T cells.
eLife. Roč. 10, DEC 21 2021 (2021), č. článku e62432. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA ČR GA13-12885S; GA ČR(CZ) GA18-12973S; GA MZd(CZ) NV19-03-00179
Institutional support: RVO:61388971
Keywords : il-2 * tolerance * responses * suppression * il-2 * anti-il-2 mab complexes * cd25 * T cells * IFN-gamma * lps * hyperreactivity * Mouse
OECD category: Immunology
Impact factor: 8.713, year: 2021
Method of publishing: Open access
https://elifesciences.org/articles/62432
Permanent Link: http://hdl.handle.net/11104/0326088 - 5.0543231 - MBÚ 2022 RIV GB eng J - Journal Article
Glassman, C. R. - Su, L. - Majri-Morrison, S. S. - Winkelmann, H. - Mo, F. - Li, P. - Perez-Cruz, M. - Ho, P. P. - Koliesnik, I. - Nagy, N. - Hnízdilová, Tereza - Picton, L.K. - Kovář, Marek - Bollyky, P. - Steinman, L. - Meyer, E. - Piehler, J. - Leonard, W. J. - Garcia, K. C.
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife. Roč. 10, MAY 18 2021 (2021), č. článku e65777. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA ČR(CZ) GA18-12973S
Institutional support: RVO:61388971
Keywords : il-2 receptor * molecular-cloning * gamma-chain * alpha-chain * beta-chain * mice * expression * gene * proliferation * autoimmunity
OECD category: Microbiology
Impact factor: 8.713, year: 2021
Method of publishing: Open access
https://elifesciences.org/articles/65777
Permanent Link: http://hdl.handle.net/11104/0320484 - 6.0494805 - MBÚ 2019 RIV US eng J - Journal Article
Spangler, J.B. - Trotta, E. - Tomala, Jakub - Peck, A. - Young, T.A. - Savvides, Ch.S. - Silveria, S. - Votavová, Petra - Salafsky, J. - Pande, V.S. - Kovář, Marek - Bluestone, J.A. - Garcia, K.Ch.
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.
Journal of Immunology. Roč. 201, č. 7 (2018), s. 2094-2106. ISSN 0022-1767. E-ISSN 1550-6606
R&D Projects: GA ČR GA13-12885S; GA ČR(CZ) GA18-12973S
Institutional support: RVO:61388971
Keywords : IL-2/ANTI-IL-2 MAB COMPLEXES * LOW-DOSE INTERLEUKIN-2 * CYTOKINE-RECEPTOR
OECD category: Microbiology
Impact factor: 4.718, year: 2018
Permanent Link: http://hdl.handle.net/11104/0289054File Download Size Commentary Version Access Spangler, Tomala-J. Immunol 18.pdf 7 2.6 MB Publisher’s postprint require - 7.0472725 - MBÚ 2017 RIV US eng J - Journal Article
Tomala, Jakub - Kovář, Marek
IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?
Oncoimmunology. Roč. 5, č. 3 (2016), e1102829. ISSN 2162-402X. E-ISSN 2162-402X
R&D Projects: GA ČR GA13-12885S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388971
Keywords : Anti-IL-2 mAb * cancer immunotherapy * IL-2
Subject RIV: EE - Microbiology, Virology
Impact factor: 7.719, year: 2016
Permanent Link: http://hdl.handle.net/11104/0269955File Download Size Commentary Version Access 152_IL 2 anti IL 2 mAb immunocomplexes A renascence.pdf 4 1.2 MB Publisher’s postprint require - 8.0441077 - MBÚ 2015 RIV NL eng J - Journal Article
Votavová, Petra - Tomala, Jakub - Kovář, Marek
Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and Il-15Ralfa-Fc chimera.
Immunology Letters. Roč. 195, č. 1 (2014), s. 1-10. ISSN 0165-2478. E-ISSN 1879-0542
R&D Projects: GA ČR GAP301/11/0325; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR GA13-12885S
Institutional support: RVO:61388971
Keywords : IL-2 * IL-15 * chimera
Subject RIV: EC - Immunology
Impact factor: 2.512, year: 2014
Permanent Link: http://hdl.handle.net/11104/0244107 - 9.0399622 - MBÚ 2014 RIV US eng J - Journal Article
Tomala, Jakub - Kovářová, Jiřina - Kabešová, Martina - Votavová, Petra - Chmelová, Helena - Dvořáková, Barbora - Říhová, Blanka - Kovář, Marek
Chimera of IL-2 Linked to Light Chain of anti-IL-2 mAb Mimics IL-2/anti-IL-2 mAb Complexes Both Structurally and Functionally.
ACS Chemical Biology. Roč. 8, č. 5 (2013), s. 871-876. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR GAP301/11/0325
Institutional support: RVO:61388971
Keywords : IN-VIVO EXPANSION * IL-2 * ANTIBODY
Subject RIV: CE - Biochemistry
Impact factor: 5.356, year: 2013
Permanent Link: http://hdl.handle.net/11104/0227039 - 10.0390542 - MBÚ 2013 GB eng A - Abstract
Votavová, Petra - Tomala, Jakub - Šubr, Vladimír - Ulbrich, Karel - Říhová, Blanka - Kovář, Marek
HPMA copolymer-modified IL-2 possesses superior biological activity to free IL-2 in vivo.
Immunology 137. Glasgow: Blackwell Publishing Ltd, 2012. Roč. 137, č. 1 (2012), s. 712-713. ISSN 0019-2805. E-ISSN 1365-2567.
[European Congress of Immunology – ECI 2012. 05.09.2012-08.09.2012, Glasgow]
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Interleukin * IL-2-pHPMA conjugate * T-Cell
Subject RIV: EC - Immunology
Permanent Link: http://hdl.handle.net/11104/0219490