Search results
- 1.0540961 - ÚOCHB 2022 RIV DE eng J - Journal Article
Grüner, B. - Kugler, Michael - El Anwar, S. - Holub, J. - Nekvinda, J. - Bavol, D. - Růžičková, Z. - Pospíšilová, Klára - Fábry, M. - Král, V. - Brynda, J. - Řezáčová, Pavlína
Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX.
ChemPlusChem. Roč. 86, č. 3 (2021), s. 352-363. ISSN 2192-6506. E-ISSN 2192-6506
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : anti-tumor agents * carbonic anhydrase IX * carbones * cobalt * enzyme inhibitors
OECD category: Biochemistry and molecular biology
Impact factor: 3.210, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/cplu.202000574
Permanent Link: http://hdl.handle.net/11104/0318544 - 2.0540277 - ÚMG 2021 RIV US eng J - Journal Article
Tykvart, J. - Navrátil, V. - Kugler, Michael - Šácha, P. - Schimer, J. - Hlaváčková, A. - Tenora, L. - Zemanová, J. - Dejmek, M. - Král, Vlastimil - Potáček, M. - Majer, P. - Jahn, U. - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, J.
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA).
SLAS Discovery. Roč. 25, č. 9 (2020), s. 1026-1037. ISSN 2472-5552. E-ISSN 2472-5560
Institutional support: RVO:68378050
Keywords : high-throughput screening * carbonic anhydrase IX * drug discovery * DNA-linked inhibitor antibody assay
OECD category: Biochemistry and molecular biology
Impact factor: 2.918, year: 2020
Method of publishing: Limited access
https://journals.sagepub.com/doi/10.1177/2472555220918836
Permanent Link: http://hdl.handle.net/11104/0317971 - 3.0539170 - ÚMG 2021 RIV GB eng J - Journal Article
Kugler, Michael - Holub, J. - Brynda, Jiří - Pospíšilová, K. - El Anwar, S. - Bavol, D. - Havránek, M. - Král, Vlastimil - Fábry, Milan - Gruner, B. - Řezáčová, Pavlína
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1800-1810. ISSN 1475-6366. E-ISSN 1475-6374
Institutional support: RVO:68378050
Keywords : tumor hypoxia * medicinal chemistry * drug discovery * binding-sites * inhibition * boron * pharmacophores * opportunities * conjugation * metastasis * Carbonic anhydrase IX * carborane * enzyme inhibitors * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1816996
Permanent Link: http://hdl.handle.net/11104/0316870 - 4.0534747 - ÚMG 2021 RIV CH eng J - Journal Article
Gibadulinová, A. - Bullova, P. - Strnad, Hynek - Pohlodek, K. - Jurkovičová, D. - Takacova, M. - Pastorekova, S. - Svastova, E.
CAIX-Mediated Control of LIN28/let-7Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia.
International Journal of Molecular Sciences. Roč. 21, č. 12 (2020), č. článku 4299. E-ISSN 1422-0067
Institutional support: RVO:68378050
Keywords : carbonic anhydrase IX * hypoxia * lin28 * let-7axis * metabolism
OECD category: Biochemistry and molecular biology
Impact factor: 5.924, year: 2020
Method of publishing: Open access
https://www.mdpi.com/1422-0067/21/12/4299
Permanent Link: http://hdl.handle.net/11104/0312927 - 5.0532715 - ÚOCHB 2021 RIV GB eng J - Journal Article
Kugler, Michael - Holub, Josef - Brynda, Jiří - Pospíšilová, Klára - El Anwar, Suzan - Bavol, Dmytro - Havránek, M. - Král, V. - Fábry, M. - Grüner, Bohumír - Řezáčová, Pavlína
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1800-1810. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA ČR(CZ) GA18-27648S; GA TA ČR(CZ) TE01020028; GA MŠMT(CZ) EF16_019/0000729
Grant - others:AV ČR(CZ) L200321851
Program: Program podpory perspektivníchlidských zdrojů - postdoktorandů
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : carbonic anhydrase IX * carbone * enzyme inhibitors * sulfonamide * structure-activity relationship
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://doi.org/10.1080/14756366.2020.1816996
Permanent Link: http://hdl.handle.net/11104/0311123File Download Size Commentary Version Access The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer associated carbonic anhydrase IX.pdf 2 3.7 MB Publisher’s postprint open-access - 6.0532248 - ÚACH 2022 RIV DE eng J - Journal Article
Grüner, Bohumír - Kugler, Michael - El Anwar, Suzan - Holub, Josef - Nekvinda, Jan - Bavol, Dmytro - Růžičková, Z. - Pospíšilová, K. - Fábry, Milan - Král, Vlastimil - Brynda, Jiří - Řezáčová, P.
Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX.
ChemPlusChem. Roč. 86, č. 3 (2021), s. 352-363. ISSN 2192-6506. E-ISSN 2192-6506
R&D Projects: GA ČR(CZ) GA18-27648S
Grant - others:AV ČR(CZ) L200321851
Program: Program podpory perspektivníchlidských zdrojů - postdoktorandů
Institutional support: RVO:61388980 ; RVO:68378050
Keywords : anti-tumor agents * carbonic anhydrase IX * carboranes * cobalt Bis(dicarbollide) * enzyme inhibitors
OECD category: Inorganic and nuclear chemistry; Human genetics (UMG-J)
Impact factor: 3.210, year: 2021
Method of publishing: Open access with time embargo
Permanent Link: http://hdl.handle.net/11104/0318394File Download Size Commentary Version Access Cobalt.pdf 0 1.9 MB Author’s postprint open-access Cobalt SI.pdf 0 5.5 MB Author’s postprint open-access - 7.0531266 - ÚMG 2021 RIV FR eng J - Journal Article
Dvořanová, J. - Kugler, Michael - Holub, J. - Šícha, V. - Das, V. - Nekvinda, J. - El Anwar, S. - Havránek, M. - Pospíšilová, K. - Fábry, Milan - Král, Vlastimil - Medvědiková, M. - Matějková, S. - Lišková, B. - Gurská, S. - Dzubak, P. - Brynda, Jiří - Hajduch, M. - Gruner, B. - Řezáčová, P.
Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX.
European Journal of Medicinal Chemistry. Roč. 200, August (2020), č. článku 112460. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA15-05677S
Institutional support: RVO:68378050
Keywords : Anti-tumor agents * Carbonic anhydrase IX * Carboranes * Dicarbollide * Enzyme inhibitors * Drug penetration * Multicellular spheroids
OECD category: Medicinal chemistry
Impact factor: 6.514, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0223523420304311?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0309958 - 8.0525049 - ÚOCHB 2021 RIV US eng J - Journal Article
Tykvart, Jan - Navrátil, Václav - Kugler, Michael - Šácha, Pavel - Schimer, Jiří - Hlavačková, Anna - Tenora, Lukáš - Zemanová, Jitka - Dejmek, Milan - Král, V. - Potáček, M. - Majer, Pavel - Jahn, Ullrich - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, Jan
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA).
SLAS Discovery. Roč. 25, č. 9 (2020), s. 1026-1037. ISSN 2472-5552. E-ISSN 2472-5560
R&D Projects: GA ČR(CZ) GA19-10280S; GA ČR(CZ) GA17-14510S; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : high-throughput screening * carbonic anhydrase IX * drug discovery * DNA-linked inhibitor antibody assay
OECD category: Biochemistry and molecular biology
Impact factor: 2.918, year: 2020
Method of publishing: Limited access
https://journals.sagepub.com/doi/10.1177/2472555220918836
Permanent Link: http://hdl.handle.net/11104/0309265 - 9.0524603 - ÚOCHB 2021 RIV FR eng J - Journal Article
Dvořanová, J. - Kugler, Michael - Holub, Josef - Šícha, Václav - Das, V. - Nekvinda, Jan - El Anwar, Suzan - Havránek, M. - Pospíšilová, Klára - Fábry, M. - Král, V. - Medvedíková, M. - Matějková, Stanislava - Lišková, B. - Gurská, S. - Džubák, P. - Brynda, J. - Hajdúch, M. - Grüner, Bohumír - Řezáčová, Pavlína
Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX.
European Journal of Medicinal Chemistry. Roč. 200, Aug 15 (2020), č. článku 112460. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA18-27648S; GA ČR(CZ) GA15-05677S; GA TA ČR(CZ) TE01020028; GA MŠMT(CZ) LM2015064
Grant - others:AV ČR(CZ) L200321851
Program: Program podpory perspektivníchlidských zdrojů - postdoktorandů
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : anti-tumor agents * carbonic anhydrase IX * carboranes * dicarbollide * enzyme inhibitors * drug penetration * multicellular spheroids
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 6.514, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0223523420304311?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0308946 - 10.0520890 - ÚOCHB 2020 GB eng A - Abstract
Řezáčová, Pavlína - Kugler, Michael - Brynda, Jiří - Grüner, Bohumír - Hajdúch, M. - Nekvinda, Jan - Pospíšilová, Klára - Das, V. - Holub, Josef
Structure-assisted design of Carborane inhibitors of human Carbonic anhydrase IX.
Acta Crystallographica Section A-Foundation and Advances. Oxford Blackwell. Roč. 74, Suppl (2018), „e197“. ISSN 2053-2733. E-ISSN 2053-2733.
[European Crystallography Meeting /31./. 22.08.2018-27.08.2018, Oviedo]
R&D Projects: GA ČR(CZ) GA15-05677S; GA TA ČR(CZ) TE01020028; GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LM2015064
Institutional support: RVO:61388963 ; RVO:68378050 ; RVO:61388980
Keywords : anti-tumor agents * carborane inhibitors * Carbonic anhydrase IX
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Permanent Link: http://hdl.handle.net/11104/0305557