Search results
- 1.0486699 - ÚMG 2018 RIV GB eng J - Journal Article
Müllers, E. - Cascales, H.S. - Burdová, Kamila - Macůrek, Libor - Lindqvist, A.
Residual Cdk1/2 activity after DNA damage promotes senescence.
Aging Cell. Roč. 16, č. 3 (2017), s. 575-584. ISSN 1474-9718. E-ISSN 1474-9726
R&D Projects: GA ČR GA13-18392S
Institutional support: RVO:68378050
Keywords : Cdk1 * Cdk2 * cell cycle * checkpoint recovery * DNA damage response * G2phase * p21 * senescence
OECD category: Biochemistry and molecular biology
Impact factor: 7.627, year: 2017
Permanent Link: http://hdl.handle.net/11104/0281444 - 2.0467239 - ÚEB 2017 RIV US eng J - Journal Article
Bazgier, Václav - Berka, K. - Otyepka, M. - Banáš, P.
Exponential Repulsion Improves Structural Predictability of Molecular Docking.
Journal of Computational Chemistry. Roč. 37, č. 28 (2016), s. 2485-2494. ISSN 0192-8651. E-ISSN 1096-987X
Institutional support: RVO:61389030
Keywords : cyclin-dependent kinases * structure-based design * scoring functions * cdk2 inhibitors * force-field * ligand interactions * drug discovery * purine * potent * protein-kinase-2 * molecular docking * dock 6.6 * drug design * cyclin-dependent kinase 2 * directory of decoys
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 3.229, year: 2016
Permanent Link: http://hdl.handle.net/11104/0265352File Download Size Commentary Version Access 2016_Bazgier_JOURNAL OF COMPUTATIONAL CHEMISTRY_2485.pdf 0 445.8 KB Other open-access - 3.0380560 - ÚOCHB 2013 CZ eng A - Abstract
Deepa, Palanisamy - Fanfrlík, Jindřich - Brahmkshatriya, Pathik - Brynda, Jiří - Cankař, P. - Kryštof, V. - Řezáč, Jan - Lepšík, Martin - Hobza, Pavel
Understanding the potency of competitive CDK2 inhibitors using quantum chemical scoring.
Biomedical Papers. Univerzita Palackého v Olomouci. Roč. 156, Suppl. 1 (2012), S75-S75. ISSN 1213-8118. E-ISSN 1804-7521.
[International Congress Natural Anticancer Drugs. 30.06.2012-04.07.2012, Olomouc]
R&D Projects: GA ČR GBP208/12/G016
Grant - others:European Science Foundation(XE) CZ.1.05/2.1.00/03.0058
Institutional support: RVO:61388963
Keywords : cyclin-dependent kinases * CDK2 * quantum chemical scoring
Subject RIV: CF - Physical ; Theoretical Chemistry
Permanent Link: http://hdl.handle.net/11104/0211237 - 4.0367955 - ÚEM 2012 RIV GB eng J - Journal Article
Kollár, P. - Bárta, Tomáš - Závalová, V. - Šmejkal, K. - Hampl, Aleš
Geranylated flavanone tomentodiplacone B inhibits proliferation of human monocytic leukaemia (THP-1) cells.
British Journal of Pharmacology. Roč. 162, č. 7 (2011), s. 1534-1541. ISSN 0007-1188. E-ISSN 1476-5381
Grant - others:GA MŠk.(CZ) LC06077
Program: LC
Institutional research plan: CEZ:AV0Z50390703; CEZ:AV0Z50390512
Keywords : flavonoids * CDK2 * antiproliferative effect
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 4.409, year: 2011
Permanent Link: http://hdl.handle.net/11104/0202450 - 5.0360708 - ÚOCHB 2012 RIV NL eng J - Journal Article
Dobeš, Petr - Fanfrlík, Jindřich - Řezáč, Jan - Otyepka, M. - Hobza, Pavel
Transferable scoring function based on semiempirical quantum mechanical PM6-DH2 method: CDK2 with 15 structurally diverse inhibitors.
Journal of Computer-Aided Molecular Design. Roč. 25, č. 3 (2011), s. 223-235. ISSN 0920-654X. E-ISSN 1573-4951
R&D Projects: GA MŠMT LC512; GA ČR GAP208/11/0295
Grant - others:European Social Fund(XE) CZ.1.05/2.1.00/03.0058
Institutional research plan: CEZ:AV0Z40550506
Keywords : CDK2 * semiempirical quantum mechanical method PM6-DH2 * drug design
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 3.386, year: 2011
Permanent Link: http://hdl.handle.net/11104/0198195 - 6.0188982 - UMCH-V 20023397 TR eng A - Abstract
Lapčíková, Monika - Machová, Luďka - Dvořánková, B. - Zablocki, J. - Rypáček, František
Controlled release of drugs from polylactide-film coatings.
Abstract Book. Antalya: Ankara University, Tissue Engineering and Biomaterials Laboratory, 2002. s. P-66.
[International Symposium on Biomedical Science and Technology BIOMED /9./. 19.09.2002-22.09.2002, Antalya]
R&D Projects: GA AV ČR KSK4055109
Keywords : controlled release drugs * polylactide-film coatings * CDK2 inhibitor
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0084847 - 7.0104694 - BFU-R 20043076 RIV GB eng J - Journal Article
Pospíšilová, Š. - Brázda, Václav - Kuchaříková, Kateřina - Luciani, M. G. - Hupp, T. R. - Skládal, P. - Paleček, Emil - Vojtěšek, B.
Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2.
[Aktivace schopnosti vázat se na DNA latentního p53 protein kinázou C se ruší protein kinázou CK2.]
Biochemical Journal. Roč. 378, č. 3 (2004), s. 939-947. ISSN 0264-6021. E-ISSN 1470-8728
R&D Projects: GA ČR GA301/00/P094; GA ČR GA301/02/0831; GA ČR GA301/00/D001; GA AV ČR IAB5004203; GA MŠMT OC 518.30
Institutional research plan: CEZ:AV0Z5004920
Keywords : activation * cdk2/cyclin A * DNA binding
Subject RIV: BO - Biophysics
Impact factor: 4.278, year: 2004
Permanent Link: http://hdl.handle.net/11104/0011960 - 8.0087665 - BFÚ 2008 CZ eng A - Abstract
Vaňhara, P. - Bryja, Vítězslav - Horváth, Viktor - Kozubík, Alois - Hampl, A. - Šmarda, J.
c-Jun induces apoptosis of serum-deprived BM2 monoblasts by activating cyclin A-associated CDK2 kinase.
[c-Jun indukuje apoptózu BM2 monoblastů skrze aktivaci cyklin A-CDK2 kinázy.]
Book of Abstracts. Brno, 2007. s. 138-139. ISBN 978-80-239-9591-6.
[Analytical Cytometry IV. 23.06.2007-26.06.2007, Brno]
R&D Projects: GA ČR(CZ) GA301/06/0036
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : monoblasts * apoptosis * cyclin A-CDK2
Subject RIV: BO - Biophysics
Permanent Link: http://hdl.handle.net/11104/0149461 - 9.0083873 - BFÚ 2008 RIV US eng J - Journal Article
Vaňhara, P. - Bryja, V. - Horváth, Viktor - Kozubík, Alois - Hampl, Aleš - Šmarda, J.
c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2.
[c-Jun indukuje apoptózu u BM2 monoblastů aktivací komplexu cyclin A-CDK2.]
Biochemical and Biophysical Research Communications. Roč. 353, č. 1 (2007), s. 92-97. ISSN 0006-291X. E-ISSN 1090-2104
R&D Projects: GA MŠMT(CZ) 1M0538
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : c-Jun * cyclin A * CDK2
Subject RIV: BO - Biophysics
Impact factor: 2.749, year: 2007
Permanent Link: http://hdl.handle.net/11104/0146947 - 10.0083397 - ÚEB 2008 RIV GB eng J - Journal Article
Havlíček, Libor - Fuksová, Květoslava - Kryštof, Vladimír - Orság, Martin - Vojtěšek, B. - Strnad, Miroslav
8-Azapurines as new inhibitors of cyclin-dependent kinases.
[8-Azapurines as new inhibitors of cyclin-dependent kinases.]
Bioorganic & Medicinal Chemistry. Roč. 13, č. 8 (2005), s. 5399-5407. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA AV ČR KJB6137301; GA ČR GA301/05/0418
Institutional research plan: CEZ:AV0Z50380511
Source of funding: V - Other public resources ; V - Other public resources
Keywords : CDK2 * Inhibitor * Anticancer drug
Subject RIV: FD - Oncology ; Hematology
Impact factor: 2.286, year: 2005
Permanent Link: http://hdl.handle.net/11104/0146656