Search results
- 1.0547926 - ÚEB 2022 RIV cze P - Patent Document
Plíhalová, Lucie - Zatloukal, Marek - Doležal, Karel - Strnad, Miroslav - Walla, Jan - Voller, Jiří
Mesylátová sůl para-topolinu, přípravky ji obsahující, a její použití.
[Para-topolin mesylate salt, preparations containing it, and its use.]
2021. Owner: Ústav experimentální botaniky AV ČR, v. v. i. Date of the patent acceptance: 10.06.2021. Patent Number: 308865
R&D Projects: GA TA ČR(CZ) TP01010037
Institutional support: RVO:61389030
Keywords : mesylate salt * anti-inflammatory activity * anti-senescent activity
OECD category: Organic chemistry
https://isdv.upv.cz/doc/FullFiles/Patents/FullDocuments/308/308865.pdf
Permanent Link: http://hdl.handle.net/11104/0324079File Download Size Commentary Version Access PATENTOVÝ SPIS_CZ308865.pdf 3 1.1 MB Other open-access - 2.0531731 - ÚEB 2021 RIV FR eng J - Journal Article
Šíša, Miroslav - Dvořáková, Marcela - Temml, V. - Jarošová, Veronika - Vaněk, Tomáš - Landa, Přemysl
Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.
European Journal of Medicinal Chemistry. Roč. 204, 15 October (2020), č. článku 112620. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LTC18065
Grant - others:OPPK(CZ) CZ.2.16/3.1.00/ 21519
Institutional support: RVO:61389030
Keywords : 5-Lipoxygenase * Anti-inflammatory activity * Cyclooxygenase * Quinones * Resorcinols
OECD category: Organic chemistry
Impact factor: 6.514, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.ejmech.2020.112620
Permanent Link: http://hdl.handle.net/11104/0310351File Download Size Commentary Version Access 2020_Sisa_European Journal of Medicinal Chemistry_112620.pdf 1 1.5 MB Other open-access - 3.0531060 - ÚEB 2021 RIV US eng J - Journal Article
Savić, M. P. - Škorić, D. - Kuzminac, I. Z. - Jakimov, D. S. - Kojić, V. V. - Rárová, Lucie - Strnad, Miroslav - Djurendić, E. A.
New A-homo lactam D-homo lactone androstane derivative: Synthesis and evaluation of cytotoxic and anti-inflammatory activities in vitro.
Steroids. Roč. 157, MAY (2020), č. článku 108596. ISSN 0039-128X. E-ISSN 1878-5867
R&D Projects: GA ČR(CZ) GA19-01383S
Institutional support: RVO:61389030
Keywords : ADME analysis in silico * Anti-angiogenic activity * Anti-inflammatory activity * Apoptotic morphology * Cytotoxic activity * Structural analysis
OECD category: Organic chemistry
Impact factor: 2.668, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.steroids.2020.108596
Permanent Link: http://hdl.handle.net/11104/0309810File Download Size Commentary Version Access 2020_Savic_STEROIDS_108596.pdf 1 1.1 MB Other open-access - 4.0517349 - ÚEB 2020 RIV CZ cze L - Prototype, f. module
Šíša, Miroslav - Landa, Přemysl - Vaněk, Tomáš
Nová protizánětlivá léčiva založená na přírodních látkách.
[New anti-inflammatory drugs based on natural substances.]
Internal code: DP032016 ; 2018
Technical parameters: Připravené sloučeniny byly charakterizovány pomocí 1H a 13C NMR, MS a elementární analýzy, čistota byla ověřena HPLC/UV. Biochemickým měřením s rekombinantními enzymy byly stanoveny hodnoty IC50 pro vybrané proteinkinázy, které deklarují vysokou aktiviti a selektivitu vůči CDK v řádu nM. In vitro účinnost byla ověřována pomocí MTT/resazurinu, detekcí proliferačních a apoptotických markerů. In vivo účinnost byla ověřena na myším xenotransplantačním modelu. Stanoveny byly základní parametry ADME/T.
Economic parameters: Látky se schopností inhibovat oba pro-zánětlivé enzymy (COX-2 a 5-LOX) jsou považovány za perspektivní při léčbě zánětlivých onemocnění. Získané látky s protizánětlivým účinkem mohou být využity jako nová lěčiva.
R&D Projects: GA TA ČR(CZ) TG03010009
Institutional support: RVO:61389030
Keywords : plant quinones * organic synthesis * anti-inflammatory activity
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0302669 - 5.0507476 - ÚEB 2020 RIV CH eng M - Monography Chapter
Voller, Jiří - Maková, Barbara - Kadlecová, Alena - Gonzalez, Gabriel - Strnad, Miroslav
Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases.
Healthy Ageing and Longevity. In: HORMONES IN AGEING AND LONGEVITY. Cham: Springer, 2017 - (Rattan, S.; Sharma, R.), Roč. 6 (2017), s. 311-335. ISBN 978-3-319-63001-4
R&D Projects: GA MŠMT(CZ) LO1204; GA ČR GA17-14007S
Institutional support: RVO:61389030
Keywords : Cytokinin * Kinetin * Kinetin riboside * antiproliferative activity * induced differentiation * huntingtons-disease * biological-activity * cell-proliferation * adenosine receptor * oxidative damage * Zeatin * Benzyl adenine * Topolin * Skin * Anti-aging * Anti-inflammatory activity * Neuro protection
OECD category: Oncology
Permanent Link: http://hdl.handle.net/11104/0298454File Download Size Commentary Version Access 2017_Voller_chapter_Springer_311.pdf 0 353.2 KB Other open-access - 6.0499587 - ÚEB 2019 RIV eng P - Patent Document
Landa, Přemysl - Šíša, Miroslav - Vaněk, Tomáš - Rárová, Lucie
PRIMIN DERIVATIVES, METHOD OF PREPARATION THEREOF AND USE THEREOF.
2018. Owner: Ústav experimentální botaniky AV ČR, v. v. i. Date of the patent acceptance: 19.12.2018. Patent Number: ZA2017/08339
Institutional support: RVO:61389030
Keywords : primin derivatives * Anti-inflammatory activity * pharmaceutical industry
OECD category: Organic chemistry
https://patentsearch.cipc.co.za/patents/patdetails.aspx?data=oXc%2bbAUVDnkljcXGVvMYJInzt4ORl9PsUIjgtDCYTDDBQIybCiTb8aYVHmyPy5JjmE2ZpsfiByCZHGUPJFyJ4AOTK5JBmzoHRhPC31t8njkLUwHB%2bsZhkpD0ye82P4mq
Permanent Link: http://hdl.handle.net/11104/0291801File Download Size Commentary Version Access Notification of Acceptance.pdf 5 71.4 KB Other open-access Acceptance Notice.pdf 5 39.8 KB Other open-access 2018_Landa_patent_ZA2017_08339.pdf 8 73.6 KB Other open-access - 7.0490717 - MBÚ 2019 RIV US eng J - Journal Article
Kupcová, K. - Štefanová, I. - Plavcová, Z. - Hošek, J. - Hrouzek, Pavel - Kubec, R.
Antimicrobial, Cytotoxic, Anti-Inflammatory, and Antioxidant Activity of Culinary Processed Shiitake Medicinal Mushroom (Lentinus edodes, Agaricomycetes) and Its Major Sulfur Sensory-Active Compound-Lenthionine.
International Journal of Medicinal Mushrooms. Roč. 20, č. 2 (2018), s. 165-175. ISSN 1521-9437. E-ISSN 1940-4344
R&D Projects: GA MŠMT(CZ) LO1416; GA MŠMT(CZ) ED2.1.00/19.0392
Institutional support: RVO:61388971
Keywords : anti-inflammatory activity * antimicrobial activity * antioxidant activity
OECD category: Microbiology
Impact factor: 1.423, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284900 - 8.0465178 - ÚEB 2017 RIV FR eng J - Journal Article
Lamie, P.F. - Ali, W.A.M. - Bazgier, Václav - Rárová, Lucie
Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.
European Journal of Medicinal Chemistry. Roč. 123, NOV 10 (2016), s. 803-813. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : Indole derivatives * Antiproliferative activity * Anti-inflammatory activity
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.519, year: 2016
Permanent Link: http://hdl.handle.net/11104/0263843File Download Size Commentary Version Access 2016_Lamie_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_803.pdf 1 1.3 MB Other open-access - 9.0458741 - ÚOCHB 2017 RIV CH eng J - Journal Article
Acikara, O. B. - Hošek, J. - Babula, P. - Cvačka, Josef - Buděšínský, Miloš - Dračínský, Martin - Iscan, G. S. - Kadlecová, D. - Ballová, L. - Šmejkal, K.
Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-kappa B Activation, Showing Anti-Inflammatory Effect in Vitro.
Molecules. Roč. 21, č. 1 (2016), č. článku 43. E-ISSN 1420-3049
Institutional support: RVO:61388963
Keywords : anti-inflammatory activity * IL-1 beta * NF-kappa B * Scorzonera * phenolic * TNF-alpha * triterpen
Subject RIV: CC - Organic Chemistry
Impact factor: 2.861, year: 2016
http://www.mdpi.com/1420-3049/21/1/43/htm
Permanent Link: http://hdl.handle.net/11104/0258990 - 10.0433742 - ÚEB 2015 RIV PK eng J - Journal Article
Landa, Přemysl - Skálová, L. - Boušová, I. - Kutil, Zsófia - Langhansová, Lenka - Lou, J.D. - Vaněk, Tomáš
In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.
Pakistan Journal of Pharmaceutical Sciences. Roč. 27, č. 1 (2014), s. 103-106. ISSN 1011-601X
R&D Projects: GA MŠMT ME08070
Institutional support: RVO:61389030
Keywords : anti-proliferative activity * anti-inflammatory activity * breast cancer
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 0.682, year: 2014
http://www.pjps.pk/wp-content/uploads/pdfs/27/1/Paper-15.pdf
Permanent Link: http://hdl.handle.net/11104/0237917File Download Size Commentary Version Access 2014_Landa_Pakistan journal of pharmaceutical sciences_103.pdf 2 155.9 KB Other open-access