Antifouling fluoropolymer-coated nanomaterials for 19F MRI

Daniel Jirak; Jan Svoboda; Marcela Filipová; Ognen Pop-Georgievski; Ondrej Sedlacek

doi:10.1039/D1CC00642H

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Antifouling fluoropolymer-coated nanomaterials for ¹⁹F MRI†

Daniel Jirak,

^ab Jan Svoboda,

^c Marcela Filipová,

^c Ognen Pop-Georgievski

^c and Ondrej Sedlacek

*^d

Author affiliations

* Corresponding authors

^a Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic

^b Department of Science and Research, Faculty of Health Studies, Technical University of Liberec, Liberec 461 17, Czech Republic

^c Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 6 162 06, Czech Republic

^d Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague 2 128 40, Czech Republic
E-mail: sedlacek@natur.cuni.cz

Abstract

We developed a multifunctional polymer coating for nanoparticles (NPs) that enables simultaneous detection by ¹⁹F MRI and shielding from blood plasma fouling. The coating is based on a water-soluble fluorinated poly(N-(2-fluoroethyl)acrylamide) (PFEAM) that shows high ¹⁹F MRI sensitivity, cytocompatibility and excellent antifouling properties, significantly outperforming polyethylene glycol. A proof-of-concept experiment was performed by synthesizing polymer-coated gold NPs that were successfully visualized by ¹⁹F MRI at magnetic fields close to the fields used in clinical practice. This universal approach can be used for coating and tracing of various NPs upon suitable polymer chain-end modification.

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Article information

DOI: https://doi.org/10.1039/D1CC00642H
Article type: Communication
Submitted: 03 Feb 2021
Accepted: 05 Apr 2021
First published: 14 Apr 2021

Download Citation

Chem. Commun., 2021,57, 4718-4721

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Antifouling fluoropolymer-coated nanomaterials for ¹⁹F MRI

D. Jirak, J. Svoboda, M. Filipová, O. Pop-Georgievski and O. Sedlacek, Chem. Commun., 2021, 57, 4718 DOI: 10.1039/D1CC00642H

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Chemical Communications