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Peripheral Modulators of Appetite in Eating Disorders

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Eating Disorders

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Abstract

Regulation of food intake is complex, with many peripheral and central inputs. The goal of these inputs is homeostatic maintenance of stable weight and optimal nutrient supplies. Homeostatic regulation includes central mechanisms in the hypothalamus and peripheral short- and long-term mechanisms, mediated mainly by gastrointestinal and adipose tissue peptides. Appetite and feeding regulating factors can be described as orexigenic (appetite and feeding-enhancing) or anorexigenic (appetite and feeding-reducing). Orexigenic factors involve peripheral ghrelin and the centrally acting NPY/AgRP system. Anorexigenic factors include gastrointestinal peptides, the adipose tissue hormone leptin, and the centrally acting melanocortin system. In addition to homeostatic regulation, hedonic and cognitive feedback neurocircuits influence feeding and appetite, and their dysfunction plays an essential role in the onset and maintenance of several psychiatric diseases, mainly eating disorders. In-depth knowledge of changes in brain connectivity and central and peripheral mechanisms of food intake regulation is crucial for understanding the pathogenesis of eating disorders, obesity, and comorbidities.

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Acknowledgments

The study was supported by the Ministry of Health of the Czech Republic, grant nr. NU20-04-00088, NU22-04-00010 and NU23-04-00381

Author information

Authors and Affiliations

  1. Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic

    Petra Prochazkova & Radka Roubalova

  2. Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

    Hana Papezova

Authors
  1. Petra Prochazkova
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  2. Radka Roubalova
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  3. Hana Papezova
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Corresponding author

Correspondence to Petra Prochazkova .

Editor information

Editors and Affiliations

  1. University College London, London, UK

    Paul Robinson

  2. School of Psychology, Flinders University, Adelaide, SA, Australia

    Tracey Wade

  3. Klinik für Psychiatrie, Psychosomatik, Uniklinik der RWTH Aachen, Aachen, Nordrhein-Westfalen, Germany

    Beate Herpertz-Dahlmann

  4. Department of Psychiatry-IDIBELL, University of Barcelona, Barcelona, Spain

    Fernando Fernandez-Aranda

  5. Dept of Psychological Med IoPPN, Kings College London, London, UK

    Janet Treasure

  6. School of Medicine and Health Sciences, University of North Dakota, Fargo, USA

    Steve Wonderlich

Section Editor information

  1. Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom

    Hubertus Himmerich

  2. Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, Salerno, Italy

    Palmiero Monteleone

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Prochazkova, P., Roubalova, R., Papezova, H. (2023). Peripheral Modulators of Appetite in Eating Disorders. In: Robinson, P., Wade, T., Herpertz-Dahlmann, B., Fernandez-Aranda, F., Treasure, J., Wonderlich, S. (eds) Eating Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-97416-9_113-1

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  • DOI: https://doi.org/10.1007/978-3-030-97416-9_113-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-97416-9

  • Online ISBN: 978-3-030-97416-9

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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