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Controlling Cell Membrane Potential with Static Nonuniform Magnetic Fields

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Book cover Biological Effects of Static Magnetic Fields

Abstract

The coordinated activity of a myriad of ion channels in a cell is a spectacular biological and physical phenomenon. Understanding mechanisms governing the ion channel gating and setting membrane potentials is key to developing targeted therapeutic strategies using non-contact magnetic stimulations. In this study, we demonstrate theoretically that ion channel activity can be controlled by a static gradient magnetic field. The analysis revealed that specific ion membrane channels can be turned off and on by remotely applying a high-gradient magnetic field, thus modulating the cell membrane potential. The suggested model and mechanisms provide a general framework for identifying possible hidden mechanisms of biomagnetic effects associated with modulation of ion channel activity by high-gradient static magnetic fields.

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Authors and Affiliations

  1. Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, Prague, Czech Republic

    Vitalii Zablotskii, Tatyana Polyakova & Alexandr Dejneka

  2. International Magnetobiology Frontier Research Center, Hefei, China

    Vitalii Zablotskii

Authors
  1. Vitalii Zablotskii
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  2. Tatyana Polyakova
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  3. Alexandr Dejneka
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Correspondence to Vitalii Zablotskii .

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Editors and Affiliations

  1. CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, High Magnetic Field Laboratory of Chinese Academy of Sciences (CHMFL), HFIPS, CAS, Hefei, Anhui, China

    Xin Zhang

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Zablotskii, V., Polyakova, T., Dejneka, A. (2023). Controlling Cell Membrane Potential with Static Nonuniform Magnetic Fields. In: Zhang, X. (eds) Biological Effects of Static Magnetic Fields. Springer, Singapore. https://doi.org/10.1007/978-981-19-8869-1_5

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