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Effect of Ni ion release on the cells in contact with NiTi alloys

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Abstract

Nickel-titanium alloys have been used in medical applications for several years; however, biocompatibility of the material remains controversial. In the present study, the human umbilical vein endothelial cells (HUVEC) were cultured in contact with the nitinol used in two different heat treatment  surface modifications—helium and hydrogen. The amount of Ni ions released from these alloys in contact with HUVEC was measured in media and in the cells by ICP-MS. An increased release of Ni ions was detected in He alloy compared with H2 alloy modification with an elevation with the metal exposition duration (24 h vs. 72 h). The cells contained the Ni ions in both selected alloy modifications with the lower levels in H2 alloys. To evaluate the potential of multiple metal applications, similar values were observed in media and in cell suspension for all surface modification combinations. The model analysis of effect of metal ion release on distant cells in the body showed that the concentration is interestingly similar to concentrations in cells in direct contact with the metal alloy. The cells are able to regulate the concentration of Ni ions within the cell. According to our best knowledge, the study for the first time describes the presence of Ni ions released from nitinol directly in the cells. In the case of the H2 modification, the lowest levels of Ni ions were detected both in medium and in the cells, which likely increases the biocompatibility of the nitinol alloy.

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Funding

This study received financial support from the Czech Science Foundation under the contract no. 15-16336S.

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Authors and Affiliations

  1. Institute of Pathological Physiology, Medical Faculty, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic

    Jana Veverkova & Monika Pavkova Goldbergova

  2. Academy of Sciences CR, Institute of Physics of Materials, Zizkova 22, 616 62, Brno, Czech Republic

    Denisa Bartkova, Adam Weiser & Antonin Dlouhy

  3. Institute of Physiology, Medical Faculty, Masaryk University, 625 00, Brno, Czech Republic

    Petr Babula & Petr Stepka

Authors
  1. Jana Veverkova
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  2. Denisa Bartkova
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  6. Petr Stepka
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  7. Monika Pavkova Goldbergova
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Correspondence to Monika Pavkova Goldbergova.

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Responsible editor: Philippe Garrigues

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Highlights

1. The Ni ion release is affected by heat treatment surface modification of NiTi alloy (He vs. H2).

2. Ni ions released from NiTi alloy enter the cells in both surface modifications.

3. Similar level of nickel ions in the cells was detected as effect of medium with metal ions.

4. Cells are able to release and regulate absorbed Ni ions.

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Veverkova, J., Bartkova, D., Weiser, A. et al. Effect of Ni ion release on the cells in contact with NiTi alloys. Environ Sci Pollut Res 27, 7934–7942 (2020). https://doi.org/10.1007/s11356-019-07506-8

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  • DOI: https://doi.org/10.1007/s11356-019-07506-8

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