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Degradation of biologically active substances by vapor-phase hydrogen peroxide

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Abstract

We have examined the potential of vapor-phase hydrogen peroxide (VPHP) for degradation of 21 structurally different pharmaceutical substances. Our results show that VPHP can be used to degrade pharmaceuticals, but it was not universally applicable to all the drugs tested. Structural analysis revealed a significant correlation of the molecular structure of a compound with its susceptibility to VPHP. Tertiary amino groups seem to be the initiation centers, although the overall susceptibility of a substance depends on other factors also. Several tested substances underwent significant structural changes, suggesting a possible decrease in their biological activity. As far as we are aware, this is one of the first reports of application of VPHP to the decontamination of hazardous chemicals.

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Acknowledgments

The project is supported by the grant of Ministry of Defense of the Czech Republic (OVVSCHT200901).

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Authors and Affiliations

  1. Department of Organic Technology, Institute of Chemical Technology Prague (ICT Prague), Technicka 5, 16628, Prague 6, Czech Republic

    Jiří Švrček, Kamila Syslová, David Stíbal & Petr Kačer

  2. Laboratory of Molecular Structure Characterization, Institute of Microbiology of ASCR, v.v.i, Videnska 1083, 14220, Prague 4, Czech Republic

    Marek Kuzma

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  1. Jiří Švrček
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  2. Kamila Syslová
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  3. David Stíbal
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  4. Marek Kuzma
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  5. Petr Kačer
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Correspondence to Petr Kačer.

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Švrček, J., Syslová, K., Stíbal, D. et al. Degradation of biologically active substances by vapor-phase hydrogen peroxide. Res Chem Intermed 40, 619–626 (2014). https://doi.org/10.1007/s11164-012-0987-x

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  • DOI: https://doi.org/10.1007/s11164-012-0987-x

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