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Magnetic cobalt oxide nanosheets: green synthesis and in vitro cytotoxicity

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Abstract

Cobalt oxide nanoparticles were prepared via green chemistry route and fully characterized by Field Emission Scanning Electron Microscope (FESEM), Energy-dispersive X-ray spectroscopy (EDAX), X-ray diffraction (XRD), High-resolution transmission electron microscopy (HRTEM) and Transmission electron microscopy (TEM) analyses; the CoO and Co3O4 nanoparticles, in sheet-shaped cobalt oxide form, ensued simultaneously in one step. The varying concentrations of NPs were analyzed via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test on the cancer cell line (U87) which revealed that with increasing concentration of cobalt oxide nanoparticles, the survival rate of U87 tumor cells decreases; IC50 of nanoparticles being ~ 55 µg/ml−1.

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Acknowledgements

This work was supported by Bam and Shahid Beheshti University of Medical Sciences and, the VEGA Agency under the Contract no. 2/0140/20. Electron microscopy at the Institute of Macromolecular Chemistry was supported through Grants 17-05007S (Czech Science Foundation) and POLYMAT LO1507 (Ministry of Education, Youth and Sports of the CR, program NPU I).

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Authors and Affiliations

  1. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran

    Mahammadali Raeisi, Mohades Peydayesh, Mehrdad Khatami & Fatemeh Bagheri Baravati

  2. Biotechnology Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hajar Q. Alijani

  3. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Mehrdad Khatami

  4. Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fariba Borhani

  5. Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06, Prague, Czech Republic

    Miroslav Šlouf

  6. Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran

    Simin Soltaninezhad

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  1. Mahammadali Raeisi
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Raeisi, M., Alijani, H.Q., Peydayesh, M. et al. Magnetic cobalt oxide nanosheets: green synthesis and in vitro cytotoxicity. Bioprocess Biosyst Eng 44, 1423–1432 (2021). https://doi.org/10.1007/s00449-021-02518-6

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