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Characterization of the Morphological Nature of Hollow Spray Dried Dispersion Particles Using X-ray Submicron-Computed Tomography

  • Brief/Technical Note
  • Theme: Advancements in Amorphous Solid Dispersions to Improve Bioavailability
  • Published:
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Acknowledgements

The BMS team would like to thank Srini Sridharan, Tracy Gaebele, Ana Ferreira, Sai Jayaraman, Patrick Wray, and Andy Ilott (all Bristol-Myers Squibb) for their support during this study and Keith Tame (Scientific & Medical) for instigating the initial collaboration.

Funding

The CEITEC team acknowledges CzechNanoLab Research Infrastructure supported by MEYS CR (LM2018110).​ Jozef Kaiser also acknowledges the support of grant FSI-S-20-6353.

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Authors and Affiliations

  1. Materials Science & Engineering, Bristol Myers Squibb, Reeds Lane, Moreton, Wirral, CH46 1QW, UK

    John F. Gamble & Mike Tobyn

  2. DigiM Solution LLC, Burlington, Massachusetts, 01803, USA

    Shawn Zhang & Aiden Zhu

  3. CEITEC - Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, 612 00, Brno, Czech Republic

    Jakub Šalplachta, Jan Matula, Tomáš Zikmund & Jozef Kaiser

  4. Institute of Physics, Academy of Sciences of the Czech Republic v.v.i., Na Slovance 1999/2, 182 21, Praha 8, Czech Republic

    Peter Oberta

Authors
  1. John F. Gamble
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  2. Mike Tobyn
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  4. Aiden Zhu
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  7. Tomáš Zikmund
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  8. Jozef Kaiser
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  9. Peter Oberta
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Contributions

John Gamble: Conception and design of the work, interpretation of the data, drafting of the work, and final approval of the version to be published

Mike Tobyn: Contributions to the conception, design of the work and drafting/revising of the content, and final approval of the version to be published

Shawn Zhang: Contributions to the design of the work, acquisition and analysis of data, drafting/revising of the content, and final approval of the version to be published

Aiden Zhu: Acquisition and analysis of data, drafting/revising of the content, and final approval of the version to be published

Jakub Šalplachta: Acquisition and analysis of data, drafting/revising of the content, and final approval of the version to be published

Jan Matula: Acquisition and analysis of data, drafting/revising of the content, and final approval of the version to be published

Tomáš Zikmund: Acquisition and analysis of data, drafting/revising of the content, and final approval of the version to be published

Jozef Kaiser: Acquisition and analysis of data, drafting/revising of the content, and final approval of the version to be published

Peter Oberta: Contributions to the design of the work, drafting/revising of the content, and final approval of the version to be published

Corresponding author

Correspondence to John F. Gamble.

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The authors declare no competing interests.

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Gamble, J.F., Tobyn, M., Zhang, S. et al. Characterization of the Morphological Nature of Hollow Spray Dried Dispersion Particles Using X-ray Submicron-Computed Tomography. AAPS PharmSciTech 23, 40 (2022). https://doi.org/10.1208/s12249-021-02184-7

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