Skip to main content
SpringerLink
Log in

Simple Fabrication of Polycaprolactone-co-lactide Membrane with Silver Nanowires: Synthesis, Characterization and Cytotoxicity Studies

  • Published:
Fibers and Polymers Aims and scope Submit manuscript

Abstract

Our simple technique of polymer/metal-based material preparation produces very promising material, and we outline that this material can be suitable for the potential wound healing multilayered dressing. In our research we focused on these main issues: (1) the preparation of silver nanowire-like structures using gallic acid (GA); (2) direct silver nanowire-like structure crystallization of co-polymer L-lactide and ε-caprolactone (PLCL) electrospun fiber and (3) evaluation of the material cytotoxicity on the Vero cell line. Synthesized silver nanowire-like width varied from 30 to 100 nm and the hexagonal particles had sizes from 80 to 300 nm. The detected structures were crystalline cubic silver and were similarly synthesized during both batch synthesis and direct synthesis on the PLCL fibers. The amount of the silver spread within the fibrous membrane was approximately 1.1 wt. % in the sample, moreover, the silver incorporation had no influence on the polymer structure, which was confirmed by FTIR measurement. The cytotoxicity testing estimated that cell survival increased with decreased concentration of GA and silver in the PLCL matrix and the silver-based sample in 50 % MTT extraction concentration maintained required non-cytotoxic properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Stamm in “Nano-size Polymers: Preparation, Properties, Applications” (S. Fakirov Ed.), pp.3–15, Springer International Publishing, Cham, 2016.

  2. O. Jirsak, F. Sanetrnik, D. Lukas, V. Kotek, L. Martinova, and J. Chaloupek, Patent, WO2005024101A1 (2005).

    Google Scholar 

  3. M. Pokorny, J. Novak, J. Rebicek, J. Klemes, and V. Velebny, Nanomater. Nanotechnol., 5, 17 (2015).

    Article  Google Scholar 

  4. D. Lukáš, A. Sarkar, L. Martinová, K. Vodsed’álková, D. Lubasová, J. Chaloupek, P. Pokorný, P. Mikeš, J. Chvojka, and M. Komárek, Text. Prog., 41, 59 (2009).

    Article  Google Scholar 

  5. J. Horáková, P. Mikeš, A. Šaman, V. Jenčová, A. Klápšťová, T. Švarcová, M. Ackermann, V. Novotný, T. Suchý, and D. Lukáš, Mater. Sci. Eng. C, 92, 132 (2018).

    Article  Google Scholar 

  6. P. Mikeš, J. Horáková, A. Šaman, L. Vejsadová, P. Topham, W. Punyodom, M. Dumklang, and V. Jenčová, J. Ind. Text., 50, 870 (2019).

    Article  Google Scholar 

  7. Z. Vilamová, Z. Konvičková, P. Mikeš, V. Holišová, P. Mančík, E. Dobročka, G. Kratošová, and J. Seidlerová, Sci. Rep., 9, 15520 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  8. M. Mehrasa, M. A. Asadollahi, K. Ghaedi, H. Salehi, and A. Arpanaei, Int. J. Biol. Macromol., 79, 687 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. A. Baji, Y.-W. Mai, S.-C. Wong, M. Abtahi, and P. Chen, Compos. Sci. Technol., 70, 703 (2010).

    Article  CAS  Google Scholar 

  10. M. Liu, X.-P. Duan, Y.-M. Li, D.-P. Yang, and Y.-Z. Long, Mater. Sci. Eng. C, 76, 1413 (2017).

    Article  CAS  Google Scholar 

  11. S. Ghalei, J. Li, M. Douglass, M. Garren, and H. Handa, ACS Biomater. Sci. Eng., 7, 517 (2021).

    Article  CAS  PubMed  Google Scholar 

  12. I. V. Maggay, A. Venault, C.-Y. Fang, C.-C. Yang, C.-H. Hsu, C.-Y. Chou, K. Ishihara, and Y. Chang, ACS Biomater. Sci. Eng., 7, 562 (2021).

    Article  CAS  PubMed  Google Scholar 

  13. P. Vashisth, N. Raghuwanshi, A. K. Srivastava, H. Singh, H. Nagar, and V. Pruthi, Mater. Sci. Eng. C, 71, 611 (2017).

    Article  CAS  Google Scholar 

  14. Z. Zhang, Y. Wu, Z. Wang, X. Zhang, Y. Zhao, and L. Sun, Mater. Sci. Eng. C, 78, 706 (2017).

    Article  CAS  Google Scholar 

  15. M. Ganesh, A. S. Aziz, U. Ubaidulla, P. Hemalatha, A. Saravanakumar, R. Ravikumar, M. M. Peng, E. Y. Choi, and H. T. Jang, J. Ind. Eng. Chem., 39, 127 (2016).

    Article  CAS  Google Scholar 

  16. X. Hu, S. Liu, G. Zhou, Y. Huang, Z. Xie, and X. Jing, J. Control. Release, 185, 12 (2014).

    Article  CAS  PubMed  Google Scholar 

  17. M. R. Safaee-Ardakani, A. Hatamian-Zarmi, S. M. Sadat, Z. B. Mokhtari-Hosseini, B. Ebrahimi-Hosseinzadeh, H. Kooshki, and J. Rashidiani, Fiber. Polym., 20, 2493 (2019).

    Article  CAS  Google Scholar 

  18. K. Kalwar, W.-X. Sun, D.-L. Li, X.-J. Zhang, and D. Shan, React. Funct. Polym., 107, 87 (2016).

    Article  CAS  Google Scholar 

  19. Y. Wan, S. Yang, J. Wang, D. Gan, M. Gama, Z. Yang, Y. Zhu, F. Yao, and H. Luo, Compos. Part B Eng., 199, 108259 (2020).

    Article  CAS  Google Scholar 

  20. L. C. Stoehr, E. Gonzalez, A. Stampfl, E. Casals, A. Duschl, V. Puntes, and G. J. Oostingh, Part. Fibre Toxicol., 8, 36 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. M. Polívková, V. Štrublová, T. Hubáček, S. Rimpelová, V. Švorčík, and J. Siegel, Mater. Sci. Eng. C, 72, 512 (2017).

    Article  Google Scholar 

  22. A. Schinwald and K. Donaldson, Part. Fibre Toxicol., 9, 34 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. R. S. Jones, R. R. Draheim, and M. Roldo, Appl. Sci., 8, 673 (2018).

    Article  Google Scholar 

  24. E. N. Zare, R. Jamaledin, P. Naserzadeh, E. Afjeh-Dana, B. Ashtari, M. Hosseinzadeh, R. Vecchione, A. Wu, F. R. Tay, A. Borzacchiello, and P. Makvandi, ACS Appl. Mater. Interfaces, 12, 3279 (2020).

    Article  CAS  PubMed  Google Scholar 

  25. L. Svoboda, J. Bednár, R. Dvorský, A. Panáček, L. Hochvaldová, L. Kvítek, T. Malina, Z. Konvičková, J. Henych, Z. Nemečková, R. Večerová, M. Kolár, D. Matýsek, and Z. Vilamová, Colloids Surfaces B Biointerfaces, 202, 111680 (2021).

    Article  CAS  PubMed  Google Scholar 

  26. ISO 10993-5:2009(En), “Biological Evaluation of Medical Devices - Part 5: Tests for in Vitro Cytotoxicity”, 2009.

    Google Scholar 

  27. Y. P. Neo, S. Ray, J. Jin, M. Gizdavic-Nikolaidis, M. K. Nieuwoudt, D. Liu, and S. Y. Quek, Food Chem., 136, 1013 (2013).

    Article  CAS  PubMed  Google Scholar 

  28. D. E. Braun, R. M. Bhardwaj, A. J. Florence, D. A. Tocher, and S. L. Price, Cryst. Growth Des., 13, 19 (2013).

    Article  CAS  PubMed  Google Scholar 

  29. M. Giersig, I. Pastoriza-Santos, and L. M. Liz-Marzán, J. Mater. Chem., 14, 607 (2004).

    Article  CAS  Google Scholar 

  30. G. Viau, J.-Y. Piquemal, M. Esparrica, D. Ung, N. Chakroune, F. Warmont, and F. Fiévet, Chem. Commun., 2216 (2003).

    Google Scholar 

  31. H. Kitching, M. J. Shiers, A. J. Kenyon, and I. P. Parkin, J. Mater. Chem. A, 1, 6985 (2013).

    Article  CAS  Google Scholar 

  32. J. I. Tracey, S. Aziz, and D. M. O’Carroll, Mater. Res. Express, 6, 115067 (2019).

    Article  CAS  Google Scholar 

  33. G. Socrates, “Infrared and Raman Characteristic Group Frequencies: Tables and Charts”, Wiley, 2004.

    Google Scholar 

  34. J. R. Sarasua, Biomatter, 4, e27979 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  35. A. M. El Badawy, R. G. Silva, B. Morris, K. G. Scheckel, M. T. Suidan, and T. M. Tolaymat, Environ. Sci. Technol., 45, 283 (2011).

    Article  CAS  PubMed  Google Scholar 

  36. C. Liao, Y. Li, and S. C. Tjong, Int. J. Mol. Sci., 20, 449 (2019).

    Article  PubMed Central  Google Scholar 

  37. D.-Y. Kim, M. Kim, S. Shinde, J.-S. Sung, and G. Ghodake, Colloids Surfaces B Biointerfaces, 149, 162 (2017).

    Article  CAS  PubMed  Google Scholar 

  38. T. Rasheed, M. Bilal, H. M. N. Iqbal, and C. Li, Colloids Surfaces B Biointerfaces, 158, 408 (2017).

    Article  CAS  PubMed  Google Scholar 

  39. H. Lv, S. Cui, Q. Yang, X. Song, D. Wang, J. Hu, Y. Zhou, and Y. Liu, Mater. Sci. Eng. C, 118, 111331 (2021).

    Article  CAS  Google Scholar 

  40. X. Fang, H. Ma, S. Xiao, M. Shen, R. Guo, X. Cao, and X. Shi, J. Mater. Chem., 21, 4493 (2011).

    Article  CAS  Google Scholar 

  41. C. A. S. Ballesteros, D. S. Correa, and V. Zucolotto, Mater. Sci. Eng. C, 107, 110334 (2020).

    Article  CAS  Google Scholar 

  42. R. Alipour, A. Khorshidi, A. F. Shojaei, F. Mashayekhi, and M. J. M. Moghaddam, Polym. Test., 79, 106022 (2019).

    Article  CAS  Google Scholar 

  43. T. S. Sileika, D. G. Barrett, R. Zhang, K. H. A. Lau, and P. B. Messersmith, Angew. Chemie Int. Ed., 52, 10766 (2013).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

Many thanks to Pavlína Peikertová, Ph.D. for FTIR measurements and her kind help.

This work was kindly supported by The Ministry of Education, Youth and Sports of the Czech Republic in the following projects; (1) OP RDE grant number CZ.02.1.01/0.0/0.0/16_019/0000753 “Research centre for low carbon energy technologies”, (2) Doctoral grant competition VSB - Technical University of Ostrava, reg. no. CZ.02.2.69/0.0/0.0/19_073/0016945 within the OP RDE under project DGS/TEAM/2020-001 “Organic and inorganic pathogenic nanoparticles and the formation of appropriate protective barriers based on electroactive nanomaterials” and (3) the internal Student’s Grant Competition project “Study and Development of Composite Nanomaterials and Nanofillers No. SP 2021/106”. Work was also supported by (4) IT4Innovations national supercomputing center - path to exascale project (EF16_013/0001791), (5) by project Gamma PP1 No. TP01010036 (PRE SEED fund II VSB - Technical university of Ostrava) funded by Technology Agency of the Czech Republic and (6) OP RDE project number CZ.02.1.01/0.0/0.0/17_049/0008441 “Innovative therapeutic methods of musculoskeletal system in accident surgery”.

Author information

Authors and Affiliations

  1. Nanotechnology Centre, CEET, VŠB-Technical University of Ostrava, Ostrava, 708 00, Czech Republic

    Zuzana Šimonová, Adam Verner, Roman Gabor, Zuzana Vilamová, Ladislav Svoboda, Jiří Bednář, Richard Dvorský & Jana Seidlerová

  2. ENET Centre, CEET, VŠB-Technical University of Ostrava, Ostrava, 708 00, Czech Republic

    Zuzana Šimonová & Adam Verner

  3. Department of Machining, Assembly and Engineering Metrology, Faculty of Mechanical Engineering, VŠB-Technical University of Ostrava, Ostrava, 708 00, Czech Republic

    Zuzana Šimonová

  4. Public Health Institute Ostrava, Ostrava, 702 00, Czech Republic

    Ludmila Porubová

  5. Institute of Electrical Engineering, Slovak Academy of Sciences, Bratislava, 841 04, Slovak Republic

    Edmund Dobročka

  6. Department of Physics of Materials, Faculty of Mathemathics and Physics, Charles University, Prague, 121 16, Czech Republic

    Miroslav Cieslar

  7. Laboratory of Growth Regulators, Palacký University & Institute of Experimental Botany ASCR, Olomouc, 783 71, Czech Republic

    Veronika Krbečková

  8. Center of Advanced Innovation Technologies, VŠB-Technical University of Ostrava, Ostrava, 708 00, Czech Republic

    Kateřina Peterek Dědková

  9. IT4Innovations, VŠB-Technical University of Ostrava, Ostrava, 708 00, Czech Republic

    Ladislav Svoboda, Jiří Bednář & Richard Dvorský

  10. Department of Physical Chemistry and Theory of Technological Processes, Faculty of Materials Science and Technology, VŠB-Technical University of Ostrava, Ostrava, 708 00, Czech Republic

    Jana Seidlerová

Authors
  1. Zuzana Šimonová
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ludmila Porubová
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Adam Verner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roman Gabor
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zuzana Vilamová
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Edmund Dobročka
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Miroslav Cieslar
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Veronika Krbečková
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kateřina Peterek Dědková
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ladislav Svoboda
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jiří Bednář
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Richard Dvorský
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Jana Seidlerová
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zuzana Šimonová.

Ethics declarations

The authors declare no competing interests.

Supplemetary Materials

12221_2022_4994_MOESM1_ESM.pdf

Simple Fabrication of Polycaprolactone-co-lactide Membrane with Silver Nanowires: Synthesis, Characterization and Cytotoxicity Studies

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Šimonová, Z., Porubová, L., Verner, A. et al. Simple Fabrication of Polycaprolactone-co-lactide Membrane with Silver Nanowires: Synthesis, Characterization and Cytotoxicity Studies. Fibers Polym 23, 2983–2993 (2022). https://doi.org/10.1007/s12221-022-4994-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12221-022-4994-2

Keywords

Search

Navigation