Laboratory of Biotransformation is a part of the Institute of Microbiology of the Czech Academy of Sciences.
Research in the Laboratory of biotransformation integrates chemistry and biology to create frontier areas of molecular biocatalysis, rich in new ideas and results. Novel methodologies, search for new enzymes and new enzymatic reactions, advanced engineered biocatalysts, modern methods of structural analysis and separation procedures generate a number of new compounds that are eventually tested for various biological activities. Extensive collaborations – intramural, national and international – broaden the portfolio of methods and improve the visibility of our research. The Laboratory consists of three informal taskforce subgroups coordinated by senior researchers, i.e. “White team” (Glycobiology – Bojarová), “Blue team“ (Nitrile biotransformations – Martínková), and “Yellow team“ (Flavonoids and metabolomics – Valentová). An integrating point of the whole group is biocatalysis. More information…
News from lab
By capkova
/ 22. 3. 2024
IF 4,6 The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides, OATP1B1...
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By capkova
/ 22. 3. 2024
IF 5,8 Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca2+ elevations and mitochondrial depolarisation Z. Dostál, A.V. Zholobenko,...
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By capkova
/ 21. 3. 2024
IF 4,1 Immobilization of aldoxime dehydratases on metal affinity resins and use of the immobilized catalysts for the synthesis of...
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By capkova
/ 28. 2. 2024
Training School on Brain Cancer Study and Data Integration in Prague 24 April - 26 April...
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By capkova
/ 26. 2. 2024
IF 5,1 Glycomimetic inhibitors of tandem-repeat galectins: Simple and efficient David Vrbata, Jakub Červený, Natalia Kulik, Michaela Hovorková, Soňa Balogová,...
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By capkova
/ 21. 2. 2024
IF 4,1 Cell-free reduction of carboxylic acids with secreted carboxylic acid reductase Dominic Goj, Stella Ebner, Melissa Horvat, Simon Arhar,...
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