Cubic liquid crystalline nanostructures involving catalase and curcumin: BioSAXS study and catalase peroxidatic function after cubosomal nanoparticle treatment of differentiated SH-SY5Y cells

0521686 - FZÚ 2020 RIV CH eng J - Článek v odborném periodiku
Rakotoarisoa, M. - Angelov, Borislav - Espinoza Herrera, Shirly J. - Khakurel, Krishna - Bizien, T. - Angelova, A.
Cubic liquid crystalline nanostructures involving catalase and curcumin: BioSAXS study and catalase peroxidatic function after cubosomal nanoparticle treatment of differentiated SH-SY5Y cells.
Molecules. Roč. 24, č. 17 (2019), s. 1-21, č. článku 3058. E-ISSN 1420-3049
Grant CEP: GA MŠMT LQ1606
Institucionální podpora: RVO:68378271
Klíčová slova: liquid crystalline nanoparticles * cubosome * catalase * curcumin * fish oil * BioSAXS * peroxidatic activity of catalase * bovine liver catalase * x-ray-scattering
Obor OECD: Fluids and plasma physics (including surface physics)
Impakt faktor: 3.267, rok: 2019
Způsob publikování: Open access

The development of nanomedicines for the treatment of neurodegenerative disorders demands innovative nanoarchitectures for combined loading of multiple neuroprotective compounds. We report dual-drug loaded monoolein-based liquid crystalline architectures designed for the encapsulation of a therapeutic protein and a small molecule antioxidant. Catalase (CAT) is chosen as a metalloprotein, which provides enzymatic defense against oxidative stress caused by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Curcumin (CU), solubilized in fish oil, is co-encapsulated as a chosen drug with multiple therapeutic activities, which may favor neuro-regeneration. The prepared self-assembled biomolecular nanoarchitectures are characterized by biological synchrotron small-angle X-ray scattering (BioSAXS) at multiple compositions of the lipid/co-lipid/water phase diagram.
Trvalý link: http://hdl.handle.net/11104/0306275