Remote actuation of apoptosis in liver cancer cells via magneto-mechanical modulation of iron oxide nanoparticles

0521399 - FZÚ 2020 RIV CH eng J - Článek v odborném periodiku
Lunov, Oleg - Uzhytchak, Mariia - Smolková, Barbora - Lunova, Mariia - Jirsa, M. - Dempsey, N.M. - Dias, A.L. - Bonfim, M. - Hof, Martin - Jurkiewicz, Piotr - Petrenko, Y. - Kubinová, Šárka - Dejneka, Alexandr
Remote actuation of apoptosis in liver cancer cells via magneto-mechanical modulation of iron oxide nanoparticles.
Cancers (Basel). Roč. 11, č. 12 (2019), s. 1-21, č. článku 1873. E-ISSN 2072-6694
Grant CEP: GA MŠMT(CZ) EF16_019/0000760
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institucionální podpora: RVO:68378271 ; RVO:61388955
Klíčová slova: pulsed magnetic field * lysosomal membrane permeabilization * magnetic nanoparticles * lysosomal death pathways * apoptosis
Obor OECD: Biophysics; Physical chemistry (UFCH-W)
Impakt faktor: 6.126, rok: 2019
Způsob publikování: Open access

Lysosome-activated apoptosis represents an alternative method of overcoming tumor resistance compared to traditional forms of treatment. Pulsed magnetic fields open a new avenue for controlled and targeted initiation of lysosomal permeabilization in cancer cells via mechanical actuation of magnetic nanomaterials. In this study we used a noninvasive tool, namely, a benchtop pulsed magnetic system, which enabled remote activation of apoptosis in liver cancer cells. The magnetic system we designed represents a platform that can be used in a wide range of biomedical applications. Overall, our results show that PMF treatment of SPION-loaded lysosomes can be utilized as a noninvasive tool to remotely induce apoptosis.

Trvalý link: http://hdl.handle.net/11104/0306030