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Glass ionomer cement modified by a imidazolium salt: adding antifungal properties to a biomaterial

  • Clinical Microbiology - Short Communication
  • Published:
Brazilian Journal of Microbiology Aims and scope Submit manuscript

Abstract

We present the structural modification of a commercially available glass ionomer cement by inserting the imidazolium salt 1-n-hexadecyl-3-methylimidazolium chloride (C16MImCl), composing a new biomaterial with antifungal biofilm activity. Test specimens were prepared using a commercial glass ionomer cement to which 10 ppm of cetylpyridinium chloride (reference ionic antifungal agent) or C16MImCl were added. The feasibility and hypoallergenicity of the new biomaterial were assessed by microhardness plastic deformation and chorioallantoic membrane assays. Colony counting and scanning electron microscopy were used to evaluate the modified specimens’ antibiofilm activity against three multidrug-resistant Candida species. The modified glass ionomer cement presented a strong antibiofilm activity against Candida spp., without losing its original micromechanical and hypoallergenic properties, rendering it a promising candidate for further application in dentistry.

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Authors and Affiliations

  1. Postgraduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, 90050-170, Brazil

    Alexandre Ehrhardt, Régis A. Zanette & Alexandre Meneghello Fuentefria

  2. Laboratory of Biomedical Science, Universidade Luterana Do Brasil (ULBRA), Br 285, km 335, Carazinho, RS, 99500-000, Brazil

    Alexandre Ehrhardt & Jéssica Zolim Andreatto Mandelli

  3. Laboratory of Applied Mycology, UFRGS, Porto Alegre, RS, 90610-000, Brazil

    Vanessa Bérgamo & Alexandre Meneghello Fuentefria

  4. Biotechnology Center, UFRGS, Porto Alegre, RS, 91501-970, Brazil

    William Lopes

  5. Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic

    Ricardo Keitel Donato

Authors
  1. Alexandre Ehrhardt
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  2. Jéssica Zolim Andreatto Mandelli
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  3. Vanessa Bérgamo
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  4. William Lopes
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  5. Ricardo Keitel Donato
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  6. Régis A. Zanette
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  7. Alexandre Meneghello Fuentefria
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Contributions

AE and AMF made the conception of the work. AE wrote the draft paper with input from AMF. Writing reviews were done by RAZ. RKD obtained and curated the data. VB made the inferences and results analysis. Material preparation, data collection, and analysis were performed by AE, JZAM, and WL.

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Correspondence to Alexandre Ehrhardt.

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The authors declare no competing interests.

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Responsible Editor: Luis Henrique Souza Guimaraes

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Ehrhardt, A., Mandelli, J.Z.A., Bérgamo, V. et al. Glass ionomer cement modified by a imidazolium salt: adding antifungal properties to a biomaterial. Braz J Microbiol 52, 1347–1352 (2021). https://doi.org/10.1007/s42770-021-00511-5

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  • DOI: https://doi.org/10.1007/s42770-021-00511-5

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