Abstract
Fluorescent and magnetic nano- and microparticles have already been used for wide range of (bio)applications. Multimodal imaging as well as simultaneous control and monitoring of intracellular movements profit from the combination of these functionalities. Accordingly, several methods have been developed for the synthesis of magnetic fluorescent particles. The majority of these methods, however, require complex modification and purification steps and result in a low yield of particles. Here, we describe a straightforward and scalable method for the magnetic modification of cellulose-based fluorescent particles. The method is based on the use of microwave-synthesized magnetite nanoparticles prepared from ferrous sulfate at high pH. Magnetic modification did not change the pH sensitivity or the optical properties of the fluorescent particles, and allowed them to be manipulated by external magnetic field. Our results demonstrate the possibility of large scale, easy production of bifunctional particles. We anticipate that our method can be expanded to include other types of particles or functionalities relevant for biomedical applications.
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Acknowledgments
This research was supported by the ERDF/ESF projects No. CZ.02.1.01/0.0/0.0/17_048/0007399, No. CZ.02.1.01/0.0/0.0/17_048/0007323 and No. CZ.02.1.01/0.0/0.0/16_019/0000754 of the Ministry of Education, Youth and Sports of the Czech Republic. Research was also supported by the projects “Modified (nano)textile materials for health technologies” (No. ITMS 313011T548, Structural Funds of EU, Ministry of Education, Slovakia) and „Flexible Magnetic Filaments: Properties and Applications“ (FMF; M-ERA.NET 2). GJM is thankful for the financial support by the Austrian Research Promotion Agency (FFG) within the project 880559 (GlucoVin). This work was carried out in the frame of the COST Actions CA16215 (European network for the promotion of portable, affordable and simple analytical platforms) and CA17107 (European Network to connect research and innovation efforts on advanced Smart Textiles).
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Pospiskova, K., Mohr, G.J., Prochazkova, J. et al. Scalable production of magnetic fluorescent cellulose microparticles. Cellulose 28, 7675–7685 (2021). https://doi.org/10.1007/s10570-021-04018-y
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DOI: https://doi.org/10.1007/s10570-021-04018-y