Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity

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SYSNO	0542010
Title	Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity
Author(s)	Frydrych, Jan (UOCHB-X) [340/34] Keough, D. T. (AU) Chavchich, M. (AU) Travis, J. (AU) Dračínský, Martin (UOCHB-X) [910/91]_{RID, ORCID} Edstein, M. D. (AU) Guddat, L. W. (AU) Hocková, Dana (UOCHB-X) [340/34]_{RID, ORCID} Janeba, Zlatko (UOCHB-X) [340/34]_{RID, ORCID}
Corespondence/senior	Janeba, Zlatko - Korespondující autor
Source Title	European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021). - : Elsevier
Article number	113416
Document Type	Článek v odborném periodiku
Grant	GA19-07707S GA ČR - Czech Science Foundation (CSF), CZ - Czech Republic
Institutional support	UOCHB-X - RVO:61388963
Language	eng
Country	FR
Keywords	nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
URL	https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link	http://hdl.handle.net/11104/0319509

Number of the records: 1