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Examination of the Spatial Structure of Pigs' Melanoma in Tissue Sections Based on Histology and Mass Spectrometry
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SYSNO ASEP 0517391 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Examination of the Spatial Structure of Pigs' Melanoma in Tissue Sections Based on Histology and Mass Spectrometry Author(s) Anýz, J. (CZ)
Vysloužilová, L. (CZ)
Horák, Vratislav (UZFG-Y) RID, ORCID
Štěpánková, O. (CZ)
Vaculovič, T. (CZ)
Adam, V. (CZ)Source Title WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, vol. 1. - Prague : Springer, 2019 - ISBN 978-981-10-9035-6 Pages s. 255-259 Number of pages 5 s. Publication form Print - P Action IUPESM World Congress on Medical Physics and Biomedical Engineering Event date 03.06.2018 - 08.06.2018 VEvent location Prague Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords MeLiM ; melanoma Subject RIV FD - Oncology ; Hematology OECD category Oncology Institutional support UZFG-Y - RVO:67985904 UT WOS 000450908300046 DOI 10.1007/978-981-10-9035-6_46 Annotation We examine the spatial structure of the melanoma in tissue sections. The pigs melanoma was examined in 10 tissue samples obtained from animals of age between 4 and 22 weeks. The tissue sections were measured by light microscopy and Laser Ablation Ion Inductively Coupled Plasma Mass Spectrometry to obtain spatial metal (Cu, Zn) distribution. The exploratory analysis of the tissue sections indicates there is clearly a pattern in the spatial structure. Different projections of the spatial structure of the melanoma are obtained by the different measurement methods. The spectral clustering on the data was utilized to describe the structure in the data. According to the clustering results, there are distinct clusters of observations in the histological data. The spatial elemental distribution of the metals Cu and Zn cannot be clustered -the data form one compact cluster. The clustering of the histological images produces clusters which are related to the annotation of the biological samples in broader terms -the differences between fibrous and cancerous tissue. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2020
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