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Electrochemical Study of Highly Substituted Titanocene Dihalides
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SYSNO ASEP 0508037 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Electrochemical Study of Highly Substituted Titanocene Dihalides Author(s) Šimková, Ludmila (UFCH-W) RID, ORCID
Svoboda, J. (CZ)
Pinkas, Jiří (UFCH-W) RID, ORCID
Skoupilová, H. (CZ)
Hrstka, R. (CZ)
Dunlop, David (UFCH-W) ORCID
Lamač, Martin (UFCH-W) RID, ORCID, SAI
Gyepes, Robert (UFCH-W) RID, ORCID
Ludvík, Jiří (UFCH-W) RID, ORCIDSource Title Electroanalysis. - : Wiley - ISSN 1040-0397
Roč. 31, č. 10 (2019), s. 2067-2073Number of pages 7 s. Language eng - English Country DE - Germany Keywords dicyclopentadienyltitanium dichloride ; organometallic compounds ; pi-complexes ; reduction ; cancer ; polarography ; voltammetry ; difluorides ; ferrocenes Subject RIV CG - Electrochemistry OECD category Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis) R&D Projects GA17-05838S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UFCH-W - RVO:61388955 UT WOS 000480994500001 EID SCOPUS 85070892461 DOI 10.1002/elan.201900464 Annotation Titanocene dihalides are promising alternative to Cisplatin in cancer chemotherapy which should reduce negative side effects and overcome increasing resistance of cancer cells. Since the mechanism of anti-cancer action is associated with generation of reactive oxygen species (ROS), hence with redox processes, electrochemical investigation of titanocene species would be an important issue, not applied up to now. In this article we report on the electrochemical reduction as well as oxidation of titanocene difluorides and dichlorides where unsubstituted as well as highly substituted titanocene dihalides are compared. The experiments were realized in acetonitrile using various electrode materials. The studied series was completed by a new dimethylsilylene bridged ansa-titanocene difluoride which was characterized by NMR and x-ray crystallography. The influence of structure and substitution on the redox properties was evaluated and, in addition to this, cytotoxicity of studied titanocene dihalides against human ovarian cancer cell lines A2780 and SK-OV-3, as well as against human embryonic kidney cell line HEK293 were screened. Two of highly substituted titanocenes exhibit cytotoxicity comparable with that of Cisplatin. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2020 Electronic address http://hdl.handle.net/11104/0298992
Number of the records: 1