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Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?
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SYSNO ASEP 0504271 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed? Author(s) Chumová, Jana (MBU-M)
Kourová, Hana (MBU-M)
Trögelová, Lucie (MBU-M) ORCID
Halada, Petr (MBU-M) RID, ORCID
Binarová, Pavla (MBU-M) RID, ORCIDArticle number 259 Source Title Cells. - : MDPI
Roč. 8, č. 3 (2019)Number of pages 17 s. Language eng - English Country CH - Switzerland Keywords gamma-tubulin ; nucleation ; nuclear functions Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects GA15-11657S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000464194500002 DOI 10.3390/cells8030259 Annotation gamma-Tubulin is a conserved member of the tubulin superfamily with a function in microtubule nucleation. Proteins of gamma-tubulin complexes serve as nucleation templates as well as a majority of other proteins contributing to centrosomal and non-centrosomal nucleation, conserved across eukaryotes. There is a growing amount of evidence of gamma-tubulin functions besides microtubule nucleation in transcription, DNA damage response, chromatin remodeling, and on its interactions with tumor suppressors. However, the molecular mechanisms are not well understood. Furthermore, interactions with lamin and SUN proteins of the LINC complex suggest the role of gamma-tubulin in the coupling of nuclear organization with cytoskeletons. gamma-Tubulin that belongs to the clade of eukaryotic tubulins shows characteristics of both prokaryotic and eukaryotic tubulins. Both human and plant gamma-tubulins preserve the ability of prokaryotic tubulins to assemble filaments and higher-order fibrillar networks. gamma-Tubulin filaments, with bundling and aggregating capacity, are suggested to perform complex scaffolding and sequestration functions. In this review, we discuss a plethora of gamma-tubulin molecular interactions and cellular functions, as well as recent advances in understanding the molecular mechanisms behind them. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2020 Electronic address https://www.mdpi.com/2073-4409/8/3/259
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