Number of the records: 1
Effect of nanodiamond particles on neuronal tissue
- 1.
SYSNO ASEP 0500088 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Effect of nanodiamond particles on neuronal tissue Author(s) Šimková, Veronika (MBU-M)
Benson, Veronika (MBU-M) RID, ORCIDSource Title IMBM 2018 Proceedings. - Kladno : FBMI ČVUT, 2018 / Pánek Dalibor ; Parkman Jiří - ISBN 978-80-01-06502-0 Pages s. 59-61 Number of pages 3 s. Publication form Print - P Action Instruments and Methods for Biology and Medicine 2018 Event date 10.05.2018 - 10.05.2018 VEvent location Kladno Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords nanodiamonds ; cell cytoplasm ; neuronal tissue Subject RIV EE - Microbiology, Virology OECD category Microbiology Institutional support MBU-M - RVO:61388971 Annotation High-Pressure High-Temperature nanodiamonds are considered to be highly biocompatible due to
their low acute toxicity, which makes them suitable for biomedical applications. However, next to interaction with the cell membrane, nanoscale allows particles to penetrate the plasma membrane and even accumulate in the cell cytoplasm. Recently it brought up questions regarding sustainable nanoparticle application in vivo and potential toxicity hazards. The neuronal tissue consists of neurons and glial cells, and it is separated by a bloodbrain barrier from the peripheral blood system. Neurons are nerve cells forming a complex network of synapses that carry signals in the brain. The neurons are nourished and protected by glial cells. This project aims to find out whether nanodiamonds pass the blood-brain barrier when applied intravenously as a drug carrier and whether they directly interact with the neuronal tissue.Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2019
Number of the records: 1