Number of the records: 1
Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View
- 1.
SYSNO ASEP 0478167 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View Author(s) Cebecauer, Marek (UFCH-W) RID, ORCID, SAI
Hof, Martin (UFCH-W) RID, ORCID
Amaro, Mariana (UFCH-W) RID, ORCIDSource Title Biophysical Journal. - : Cell Press - ISSN 0006-3495
Roč. 113, č. 6 (2017), s. 1194-1199Number of pages 6 s. Language eng - English Country US - United States Keywords SURFACE-PLASMON RESONANCE ; ALZHEIMERS-DISEASE ; GM1 GANGLIOSIDE Subject RIV BO - Biophysics OECD category Biophysics R&D Projects GA17-03160S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 000411064500007 EID SCOPUS 85017394553 DOI 10.1016/j.bpj.2017.03.009 Annotation In this perspective we summarize current knowledge of the effect of monosialoganglioside GM(1) on the membrane-mediated aggregation of the beta-amyloid (A beta) peptide. GM(1) has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of A beta. However, GM(1) is known to be neuroprotective against A beta-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM(1) in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2018
Number of the records: 1