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Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages
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SYSNO ASEP 0501983 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages Author(s) Oltová, Jana (UMG-J)
Svoboda, Ondřej (UMG-J)
Bartůněk, Petr (UMG-J) RIDNumber of authors 3 Article number 174 Source Title Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
Roč. 6, December (2018)Number of pages 8 s. Language eng - English Country CH - Switzerland Keywords zebrafish ; hematopoiesis ; cytokine ; genome duplication ; myelopoiesis ; erythropoiesis Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects LO1419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA16-21024S GA ČR - Czech Science Foundation (CSF) Institutional support UMG-J - RVO:68378050 UT WOS 000455439700001 DOI 10.3389/fcell.2018.00174 Annotation Hematopoiesis is a precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish have two paralogs of many important genes, including genes involved in hematopoiesis. Importantly, these duplication events brought increased level of complexity in such cases, where both ligands and receptors have been duplicated in parallel. Therefore, precise understanding of binding specificities between duplicated ligand-receptor signalosomes as well as understanding of their differential expression provide an important basis for future studies to better understand the role of duplication of these genes. However, although many recent studies in the field have partly addressed functional redundancy or sub-specialization of some of those duplicated paralogs, this information remains to be scattered over many publications and unpublished data. Therefore, the focus of this review is to provide an overview of recent findings in the zebrafish hematopoietic field regarding activity, role and specificity of some of the hematopoietic cytokines with emphasis on crucial regulators of the erythro-myeloid lineages. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2019
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