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Rational design of sensor for broadband dielectric spectroscopy of biomolecules
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SYSNO ASEP 0490476 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Rational design of sensor for broadband dielectric spectroscopy of biomolecules Author(s) Havelka, Daniel (URE-Y) RID
Krivosudský, Ondrej (URE-Y)
Průša, Jiří (URE-Y)
Cifra, Michal (URE-Y) RID, ORCID, SAINumber of authors 4 Source Title Sensors and Actuators B - Chemical. - : Elsevier
Roč. 273, 10 November (2018), s. 62-69Number of pages 8 s. Publication form Print - P Language eng - English Country CH - Switzerland Keywords High-frequency biosensors ; Molecular dynamics ; Dielectric spectroscopy Subject RIV JA - Electronics ; Optoelectronics, Electrical Engineering OECD category Electrical and electronic engineering R&D Projects GA15-17102S GA ČR - Czech Science Foundation (CSF) Institutional support URE-Y - RVO:67985882 UT WOS 000441519000009 EID SCOPUS 85048328061 DOI 10.1016/j.snb.2018.05.124 Annotation Knowledge of electromagnetic properties of biomolecules is essential for a fundamental understanding of electric field interaction with biosystems and for development of novel biomedical diagnostic and therapeutic methods. To enable systematic analysis of the dielectric properties of biomolecule solutions we presented here a method for a rational design of radiofrequency and microwave chip for quantitative dielectric sensing. At first, we estimated the primary frequency band of interest using a relaxation time of targeted molecule via the Stokes–Einstein–Debye equation. Then we proposed a microwave sensing chip for the estimated frequency band and evaluated its performance using both analytical modeling and numerical electromagnetic simulations. We fabricated the chip and experimentally demonstrated that we can extract the complex permittivity (0.5–40 GHz) of the water solution of alanine – one of the most common proteinogenic amino acids – without any calibration liquid and with about 20-fold smaller volume than with commercial methods. The observed dependence of extracted complex permittivity on the alanine concentration was interpreted using molecular dynamics simulations. The procedure we described here can be applied for the development of dielectric sensing method of any polar biomolecule solution Workplace Institute of Radio Engineering and Electronics Contact Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Year of Publishing 2019
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