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Antifungal and antioxidant activities of Coleonema album and C. pulchellum against skin diseases

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    SYSNO ASEP0487914
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve SCOPUS
    TitleAntifungal and antioxidant activities of Coleonema album and C. pulchellum against skin diseases
    Author(s) Fajinmi, O. O. (ZA)
    Grúz, Jiří (UEB-Q) RID, ORCID
    Tarkowski, P. (CZ)
    Kulkarni, M. G. (ZA)
    Finnie, J. F. (ZA)
    Van Staden, J. (ZA)
    Number of authors6
    Source TitlePharmaceutical Biology - ISSN 1388-0209
    Roč. 55, č. 1 (2017), s. 1249-1255
    Number of pages7 s.
    Languageeng - English
    CountryGB - United Kingdom
    KeywordsAtopic dermatitis ; Trichophyton mentagrophytes ; Trichophyton rubrum
    Subject RIVEB - Genetics ; Molecular Biology
    OECD categoryDermatology and venereal diseases
    R&D ProjectsLO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportUEB-Q - RVO:61389030
    EID SCOPUS85015579251
    DOI10.1080/13880209.2017.1296470
    AnnotationContext: Coleonema album (Thunb) Bart. & H. L. Wendl (Rutaceae) has been used in the formulation of skincare products, and the Khoisan people rub it on their skin to add luster. Coleonema pulchellum I. Williams has received less attention in the South African traditional medicine. Objective: This study investigates the antifungal and antioxidant activities of C. album and C. pulchellum essential oil (EO) and leaf extracts, and analyzes the chemical components of their EOs. Materials and methods: Antifungal activity of leaf extracts was determined using the microdilution method with griseofulvin and ketoconazole as controls. Antifungal capacity of EO was investigated using the ‘Volatile release plate method’. Trichophyton rubrum (ATCC 28188) and T. mentagrophytes (ATCC 9533) mycelia (0.3cm diameter) were placed on fresh yeast malt agar in Petri dishes with filter paper (impregnated with 20 µL of EO) on the lid for direct exposure to EO volatiles while plates without EO were used as controls. The incubation time was seven days. Antioxidant activities of the leaf extracts were determined. Results: Methanol leaf extract of C. pulchellum inhibited the growth of three fungi tested with MIC values of 195, 391 and 49 µg/mL for Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum gypseum, respectively. Terpenes formed the major components of the EO. The EO from both plants inhibited the growth of T. rubrum in vitro. Discussion and conclusion: This study revealed the therapeutic value of C. pulchellum. Coleonema album and C. pulchellum should be considered as potential plants for skin ointment from natural origin.
    WorkplaceInstitute of Experimental Botany
    ContactDavid Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
    Year of Publishing2018
    Electronic addresshttp://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=MEDLINE&DestLinkType=FullRecord&UT=28262031
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