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Antifungal and antioxidant activities of Coleonema album and C. pulchellum against skin diseases
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SYSNO ASEP 0487914 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve SCOPUS Title Antifungal and antioxidant activities of Coleonema album and C. pulchellum against skin diseases Author(s) Fajinmi, O. O. (ZA)
Grúz, Jiří (UEB-Q) RID, ORCID
Tarkowski, P. (CZ)
Kulkarni, M. G. (ZA)
Finnie, J. F. (ZA)
Van Staden, J. (ZA)Number of authors 6 Source Title Pharmaceutical Biology - ISSN 1388-0209
Roč. 55, č. 1 (2017), s. 1249-1255Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords Atopic dermatitis ; Trichophyton mentagrophytes ; Trichophyton rubrum Subject RIV EB - Genetics ; Molecular Biology OECD category Dermatology and venereal diseases R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 EID SCOPUS 85015579251 DOI 10.1080/13880209.2017.1296470 Annotation Context: Coleonema album (Thunb) Bart. & H. L. Wendl (Rutaceae) has been used in the formulation of skincare products, and the Khoisan people rub it on their skin to add luster. Coleonema pulchellum I. Williams has received less attention in the South African traditional medicine. Objective: This study investigates the antifungal and antioxidant activities of C. album and C. pulchellum essential oil (EO) and leaf extracts, and analyzes the chemical components of their EOs. Materials and methods: Antifungal activity of leaf extracts was determined using the microdilution method with griseofulvin and ketoconazole as controls. Antifungal capacity of EO was investigated using the ‘Volatile release plate method’. Trichophyton rubrum (ATCC 28188) and T. mentagrophytes (ATCC 9533) mycelia (0.3cm diameter) were placed on fresh yeast malt agar in Petri dishes with filter paper (impregnated with 20 µL of EO) on the lid for direct exposure to EO volatiles while plates without EO were used as controls. The incubation time was seven days. Antioxidant activities of the leaf extracts were determined. Results: Methanol leaf extract of C. pulchellum inhibited the growth of three fungi tested with MIC values of 195, 391 and 49 µg/mL for Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum gypseum, respectively. Terpenes formed the major components of the EO. The EO from both plants inhibited the growth of T. rubrum in vitro. Discussion and conclusion: This study revealed the therapeutic value of C. pulchellum. Coleonema album and C. pulchellum should be considered as potential plants for skin ointment from natural origin. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018 Electronic address http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=MEDLINE&DestLinkType=FullRecord&UT=28262031
Number of the records: 1